Pulmonary Embolism: A Commonly Missed Clinical Entity

Uhland, Hugo; Goldberg, Leonard M.

doi:10.1378/chest.45.5.533

Cited by 78 publications

(16 citation statements)

References 14 publications

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“…This estimation is based on an autopsy study from 1964 that showed a 10% rate of antemortem diagnosis in patients who survive the first hour. 62 Assuming that the mortality rate for untreated pulmonary embolism is 30% and that 120,000 undiagnosed and, thus, untreated patients die, Dalen and Alpert 33 conclude that the diagnosis is missed in 400,000 people with pulmonary embolism.…”

Section: What Is the ''Miss Rate'' For Pulmonary Embolism?mentioning

confidence: 99%

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

Calder

Herbert

Henderson

2005

Annals of Emergency Medicine

146

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Section: What Is the ''Miss Rate'' For Pulmonary Embolism?mentioning

confidence: 99%

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

Calder

Herbert

Henderson

2005

Annals of Emergency Medicine

146

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“…Pulmonary embolism (PE) is still a diagnostic problem and no more than 20% of pulmonary emboli detected at autopsy have been diagnosed intra vitam (Coon and Coller 1955;Uhland and Goldberg 1966;Morrell and Dunnill 1968;Havig 1977). Clinical symptoms are rare and non-specific and the majority of PE are clinically silent (K6hn et al 1987;Huisman et al 1989).…”

Section: Introductionmentioning

confidence: 99%

99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study

Köhn

Mostbeck

Bachmayr³

et al. 1993

Eur J Nucl Med

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A multicentre study was performed in an attempt to evaluate a submicronic technetium-99m diethylene triamine penta-acetic acid aerosol generated by a newly developed delivery system, the aerosol production equipment (APE nebulizer), for same-day post-perfusion ventilation imaging in patients with clinically suspected pulmonary embolism. Quantitative comparison between the DTPA aerosol and krypton gas demonstrated a close correlation with respect to regional pulmonary distribution of activity and peripheral lung penetration (n = 14, r = 0.94, P < 0.001 and r = 0.75, P < 0.0025, respectively). In 169 consecutive patients, DTPA aerosol images performed immediately following perfusion (inhalation scan I) were compared to those carried out on the next day (inhalation scan II) with respect to image quality and assessment of perfusion-ventilation matches or mismatches. Agreement between inhalation scans I and II with respect to perfusion defects matched or mismatched to ventilation was found in 166/169 (98%) studies. The image quality of inhalation scan I was equal to that of scan II in 72%; inhalation scan I was superior in 11% of cases, while scan II was superior in 17%. This submicronic 99mTc-labelled DTPA aerosol is well suited for fast same-day post-perfusion ventilation imaging in patients with clinical suspicion of pulmonary embolism.

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“…Pilcher (1939), Graves (I940), Coon and Willis (1959) ~ and Uhland and Goldberg (1964) have all reported a low incidence of warning signs before death in thrombo-embolism, despite the fact that thrombi must develop in large veins. Early clinical diagnosis is thus difficult, or impossible, particularly in patients liable to develop massive emboli.…”

mentioning

confidence: 99%

The early diagnosis of deep-vein thrombosis by ultrasound

Evans

1970

Journal of British Surgery

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Pulmonary Embolism: A Commonly Missed Clinical Entity

Cited by 78 publications

References 14 publications

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

The Mortality of Untreated Pulmonary Embolism in Emergency Department Patients

99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study

The early diagnosis of deep-vein thrombosis by ultrasound

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