Pulmonary embolism and tuberculosis

Kwas, H.; Habibech, S.; Zendah, I.; Elmjendel, I.; Ghedira, Habib

doi:10.1177/0218492313485071

Cited by 10 publications

(12 citation statements)

References 3 publications

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“…Thromboembolic events are well known to occur during SARS-CoV-2 infection and may be attributed to the microangiopathic changes [19] . Like COVID-19, two other prevalent diseases in Africa, Human immunodeficiency virus (HIV) [20] and Tuberculosis [ 21 , 22 ] can independently trigger venous thromboembolism and pulmonary embolism. Thus HCWs in Africa must maintain a high level of awareness for the possibility of thromboembolism during this era of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series

Mucheleng’anga¹,

Telendiy²,

Hamukale³

et al. 2021

International Journal of Infectious Diseases

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Background Data from Africa of sudden and unexpected COVID-19 community deaths, and underlying pathological, demographic and co-morbidity features require definition. Methods We performed a descriptive case series of COVID-19 related deaths seen at Forensic Post-Mortem autopsy examination of sudden and unexpected Community Deaths in Lusaka, Zambia, Africa. Post-Mortem gross and histopathological examinations of all organs were performed according to Standard Operating Procedures. . Patient demographics, history, co-morbidities, pathological gross and microscopic findings, and cause(s) of death were recorded. Variables were grouped as frequencies and percentages. Comparison of data was made with autopsy findings of hospital COVID-19 deaths. Findings Of 21 COVID-19 decedents, 14/21 (66.2%) were male. 18/21, (85%) were below 55 years of age, (mean age, 40 ± 12.3; range, 20-73). Median duration of symptoms was 1 day (range 0-2). 9/21 (42.9%) had comorbidities, with hypertension and obesity being the most common. Main post-mortem findings were diffuse alveolar damage (DAD) (80.9%), saddle and shower emboli (38.1% respectively), and pneumonia (14.3%). Pulmonary thromboembolism (76.2%), DAD (14.3%) and SARS-CoV-2 pneumonia (9.5%) were common causes of death. Conclusions COVID-19 as cause of death in medico-legal death (forensic) investigation of sudden and unexpected community deaths Risk factors for the younger age of COVID-19 deaths and thromboembolism need to be identified.

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Section: Discussionmentioning

confidence: 99%

COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series

Mucheleng’anga¹,

Telendiy²,

Hamukale³

et al. 2021

International Journal of Infectious Diseases

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“…During the management of venous thromboembolism in patients with tuberculosis, the enzyme-inducing property of rifampicin which is used as the first line of therapy causes a challenge in attaining therapeutic anticoagulation while using warfarin [10]. Patients often require a higher dose of warfarin as in our patient and prolonged duration of heparin till a therapeutic level of INR is attained.…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism: An Unusual Presentation of Pulmonary Tuberculosis

Purayil¹,

Sirajudeen²,

Arbi³

et al. 2021

Cureus

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Tuberculosis is a leading cause of death due to infectious etiology worldwide. Myriad presentations and multisystem involvement of the disease can make the diagnosis extremely challenging. Venous thromboembolism is an uncommon entity in tuberculosis. The prevalence of venous thromboembolism is reported to be 1.5-3.4%. The etiology of thrombosis could be multifactorial. All the elements of Virchow’s triad can be present in these patients. This case report is about a patient presenting with deep vein thrombosis (DVT) and pulmonary embolism (PE), who was subsequently diagnosed with active pulmonary tuberculosis.

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“…Otro hallazgo frecuente es la presencia de anticuerpos antifosfolípidos como el anticoagulante lúpico y los anticuerpos antifosfatidiletanolamina. El primero se ha relacionado con la deficiencia parcial de proteína S, un factor anticoagulante conocido que, al disminuir, promueve la tendencia coagulante, en tanto que los segundos aumentan como reacción al proceso infeccioso de la tuberculosis (4,13,14). En el lupus eritematoso sistémico y el síndrome de anticuerpos antifosfolípidos, se ha establecido su papel como factor protrombótico dado que la fosfatidiletanolamina desempeña una función anticoagulante (7).…”

Section: Discussionunclassified

Complicaciones tromboembólicas asociadas con tuberculosis: reporte de un caso pediátrico

Osorio

Reyes

2020

biomedica

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La tuberculosis es una de las enfermedades infecciosas más comunes en el mundo. Aunque la mortalidad en niños es prácticamente nula cuando el diagnóstico y el tratamiento son oportunos, puede asociarse con complicaciones como la trombosis venosa profunda y la superficial a partir de la respuesta inflamatoria sistémica frente a la infección, lo que propicia la coagulación y ocasiona una significativa morbimortalidad.Se reporta el caso de una adolescente de 14 años con tuberculosis pulmonar en tratamiento combinado quien, de forma atípica, presentó dos episodios de tromboembolia venosa: el primero en el riñón y el segundo en los pulmones. Tras descartar el síndrome nefrótico y el antifosfolipídico, los estudios de tomografía de tórax y abdomen fueron una herramienta fundamental para su diagnóstico. Se inició tratamiento con heparina de bajo peso molecular con mejoría de los síntomas. Teniendo en cuenta las necesidades de anticoagulación no fue posible realizar estudios adicionales de ampliación.Las complicaciones tromboembólicas en pacientes con tuberculosis y sin otros factores de riesgo obligan a considerar el efecto coagulante que resulta de la reacción inflamatoria sistémica, la cual podría, por sí sola, ser la causa de una complicación significativa pero prevenible, aunque frecuentemente escapa al diagnóstico. En este sentido, se recomienda considerar la posibilidad de la tromboembolia venosa en estos pacientes y hacer un seguimiento estricto que permita aplicar el tratamiento anticoagulante tempranamente y prevenir, así, resultados adversos.

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Pulmonary embolism and tuberculosis

Cited by 10 publications

References 3 publications

COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series

COVID-19 and Sudden Unexpected Community Deaths in Lusaka, Zambia, Africa - A Medico-Legal Whole-Body Autopsy Case Series

Venous Thromboembolism: An Unusual Presentation of Pulmonary Tuberculosis

Complicaciones tromboembólicas asociadas con tuberculosis: reporte de un caso pediátrico

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