Pulmonary embolism in severe traumatic brain injury

Seifi, Ali; Dengler, Bradley A.; Martínez, Paola; Godoy, Daniel Agustín

doi:10.1016/j.jocn.2018.08.042

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…Probably the most notable finding in this study was that VOE did not impact 12-month GOS, even after adjusting for potential confounders. This is supported by previously published smaller studies of venous event subtypes in TBI, which found that mortality was not influenced by the presence of DVT, PE, [12][13][14] or CVT. 25,26 Collectively, these results indicate that VOE development does not impact outcome following moderate-to-severe TBI.…”

Section: Discussionsupporting

confidence: 87%

“…events (VOEs), such as deep vein thrombosis (DVT), pulmonary embolism (PE), cerebral venous thrombosis (CVT), embolic myocardial infarction, and embolic brain infarction. 5,6 For example, DVT has been reported in 2 to 32%, [7][8][9][10][11][12] and PE in 2 to 11%, 7,8,[10][11][12][13][14] making it more common in TBI patients than other forms of trauma. 6 A main objective of initial TBI management has therefore been to reduce bleeding progression without provoking a VOE.…”

mentioning

confidence: 99%

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Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study

Fletcher‐Sandersjöö

Tatter

Tjerkaski

et al. 2022

Semin Thromb Hemost

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Preventing hemorrhage progression is a potential therapeutic opportunity in traumatic brain injury (TBI) management, but its use has been limited by fear of provoking vascular occlusive events (VOEs). However, it is currently unclear whether VOE actually affects outcome in these patients. The aim of this study was to determine incidence, risk factors, and clinical significance of VOE in patients with moderate-to-severe TBI. A retrospective observational cohort study of adults (≥15 years) with moderate-to-severe TBI was performed. The presence of a VOE during hospitalization was noted from hospital charts and radiological reports. Functional outcome, using the Glasgow Outcome Scale (GOS), was assessed at 12 months posttrauma. Univariate and multivariate logistic regressions were used for endpoint assessment. In total, 848 patients were included, with a median admission Glasgow Coma Scale of 7. A VOE was detected in 54 (6.4%) patients, of which cerebral venous thrombosis was the most common (3.2%), followed by pulmonary embolism (1.7%) and deep vein thrombosis (1.3%). Length of ICU stay (p < 0.001), body weight (p = 0.002), and skull fracture (p = 0.004) were independent predictors of VOE. VOE development did not significantly impact 12-month GOS, even after adjusting for potential confounders using propensity score matching. In conclusion, VOE in moderate-to-severe TBI patients was relatively uncommon, and did not affect 12-month GOS. This suggests that the potential benefit of treating bleeding progression might outweigh the risks of VOE.

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study

Fletcher‐Sandersjöö

Tatter

Tjerkaski

et al. 2022

Semin Thromb Hemost

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“…It may also obstruct the blood vessels in gastro intestinal tract, kidney or legs. The drugs such as warfarin, heparins are prescribed to cure the Thrombosis [6,7].…”

Section: Comparative Analysis Of Compliance Between Rivaroxaban With mentioning

confidence: 99%

Comparative Analysis of Compliance between Rivaroxaban with Heparin & Warfarin in the Management of Deep Vein Thrombosis Tertiary Care Hospital Larkana

Abbasi¹,

Ghoto²,

Arain³

et al. 2021

RADS J. Pharm. Pharm. Sci.

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Objective: The objective behind this study is to evaluate the compliance and noncompliance, between standard therapy with latest oral anticoagulants (NOACs) with each other so as a head-to-head comparison will ever be available. Methodology: A descriptive observational study was conducted at SMBBMUH Larkana.The questionnaire (specially designed)was filled up to monitor the non-compliances associated with drugs used for the management of Deep Vein Thrombosis (DVT).The study was conducted on the 100 patients who were reported with DVT at tertiary care hospital SMBBMUH Larkana. A series of questions were asked from reported patients regarding symptoms and side effects. Finally the results were analyzed by using descriptive statistics. Results: Results show that out of 100 patients, male patients (79%) observed more than female(21%) and mostly patients perform indoor jobs (39%). Prevalence of DVT is high about 53% patients were suffering from DVT during 03 months. It was found that mostly patient non compliance observed with Warfarin (n=26) as compare to heparin (n=19) and Rivaroxaban (n=07). Conclusion: The study concluded that the more compliance achieved with Rivaroxaban as compared to warfarin and heparin. Mostly noncompliant factors are cost; prolong therapy, adverse drug reaction were common factors of non compliance in DVT patients.

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“…If the process of thrombosis is observed in deep veins of body then it is known as deep vein thrombosis (DVT). In majority of cases deep vein thrombosis is formed in legs but it can also be observed either in veins of arms or in mesenteric veins or in cerebral veins [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Venous thromboembolism diseases are considered as severe public health problem because of its significant association with increased rate of morbidity and mortality. It is enlisted as third common cause of mortality among cardiovascular diseases (CVDs) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Drug Compliance among Patients Suffering from Deep Vein Thrombosis

Ali

Mal

Soomro

et al. 2021

JPRI

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Objective: The objective of current research was to identify the compliance of commonly prescribed antithrombotic drug among patients who suffering from Deep Vein Thrombosis (DVT). Methodology: Descriptive cross-sectional research on adults with age of 18-65 years suffering from DVT were conducted on medicine department of Shaheed Mohtarma Benazir Bhutto Medical University Hospital of Larkana. Three hundred and forty eight DVT patients were consecutive selected during the period of six months from January 2021 to June 2021. Data of DVT patients was collected by using standard proforma and analyzed with statistical package of social sciences (SPSS) version 25. Results: Majority of DVT patients evaluated during study period were male 237 (61.7%) patients and 147 (38.3%) DVT patients were female. Mean age of DVT patients was 43.78 ± 12.43 (18-65) years. Most of the patients were in age group of 51-65 years having 126 (32.8%) patients followed by 41-50 years having 104 (27.1%) patients, 31-40 years having 93 (24.2%) patients and 18-30 years having 61 (15.9%) patients. Majority of DVT patients were from urban areas 217 (56.5%) patients followed by rural areas 167 (43.5%) patients. Drug compliance in illiterate patients was 107 (36.1%). Drug compliance in indoor job patients was 102 (34.5%) whereas drug compliance in jobless patients was 59 (19.1%). Drug compliance in positive medication history was 207 (69.9%). Drug compliance in Hypertensive patients was 33 (11.1%) in congestive heart failure patients 27 (9.1%), in ischemic stroke 15 (5.1%). Whereas, the drug compliance among diabetes mellitus patients was 13 (4.4%). Overall drug compliance with antithrombotic drugs was reported in 296 (77.1%) DVT patients. Conclusion: Current research concludes that rate of drug compliance was high in patients of DVT with rivaroxaban followed by warfarin and heparin, whereas long duration of therapy, polypharmacy, side effects of therapy, cost of therapy, continuous monitoring, injectables, diet restrictions and ADRs of therapy were the most commonly reported factors of non-compliance.

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Pulmonary embolism in severe traumatic brain injury

Cited by 13 publications

References 26 publications

Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study

Clinical Significance of Vascular Occlusive Events following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study

Comparative Analysis of Compliance between Rivaroxaban with Heparin & Warfarin in the Management of Deep Vein Thrombosis Tertiary Care Hospital Larkana

Analysis of Drug Compliance among Patients Suffering from Deep Vein Thrombosis

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