2015
DOI: 10.1590/1516-3180.2014.8470910
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Pulmonary emphysema induced by methylphenidate: experimental study

Abstract: CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate. DESIGN AND SETTING: Experimental study carried out at the laboratory of… Show more

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Cited by 10 publications
(7 citation statements)
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References 13 publications
(19 reference statements)
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“…Em ratos, que têm tecido pulmonar histologicamente compatíveis com humanos, a administração do MFD causou danos no parênquima pulmonar, pela destruição de septos alveolares (RAPELLO et al, 2015). O MFD pode ser considerado um agente indutor de diferenciações morfológicas em glândulas salivares de ratos (LIMA et al, 2016).…”
Section: Aplicações Terapêuticas Do Mfdunclassified
“…Em ratos, que têm tecido pulmonar histologicamente compatíveis com humanos, a administração do MFD causou danos no parênquima pulmonar, pela destruição de septos alveolares (RAPELLO et al, 2015). O MFD pode ser considerado um agente indutor de diferenciações morfológicas em glândulas salivares de ratos (LIMA et al, 2016).…”
Section: Aplicações Terapêuticas Do Mfdunclassified
“…In rats, which have histologically human-compatible lung tissue, the administration of MFD caused damage to the pulmonary parenchyma by the destruction of alveolar septa (RAPELLO et al, 2015). MFD can be considered an inducing agent of morphological differentiations in salivary glands of rats (LIMA et al, 2016).…”
Section: Adverse Reactions Of Mfd Usementioning
confidence: 99%
“…Nei ratti, che hanno tessuto polmonare istologicamente compatibile con l'uomo, la somministrazione di MFD ha causato danni al parenchima polmonare con la distruzione di setti alveolari (RAPELLO et al, 2015). L'MFD può essere considerato un agente induttore di differenziazioni morfologiche nelle ghiandole salivari dei ratti (LIMA et al, 2016).…”
Section: Reazioni Avverse Dell'uso DI Mfdunclassified