Pulmonary enteric adenocarcinoma

Handa, Yoshinori; Kai, Yuichiro; Ikeda, Takao; Mukaida, Hidenori; Egawa, Hiromi; Kaneko, Mayumi

doi:10.1007/s11748-015-0569-0

Cited by 15 publications

(16 citation statements)

References 6 publications

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“…However, an increasing interest has been addressed by both pathologists and clinicians towards this NSCLC variant, as proved by the numerous cases described in the last 3 years (Refs 11, 12, 19, 20, 23, 24, 25, 26). At present, there is the lack of consensus about the diagnostic criteria to be employed, making the differential diagnosis between PAED and MCC often complicated and mainly based on the exclusion of synchronous or metachronous gastrointestinal malignancies (Refs 8, 17, 18, 20, 21, 29, 30).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies were single-case reports or small patient series (Refs 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 16, 17, 21, 22, 29, 30, 31, 32, 34, 35, 36, 37, 38, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61) whereas sporadic cases were also described within larger studies on lung cancer, from which it was not always possible to retrieve demographic and clinical information (Refs 62, 63, 64, 65).…”

Section: Analysis Of Literature Datamentioning

confidence: 99%

“…As previously described, primary PAED diagnosis can be endorsed by excluding gastrointestinal malignancies through colonoscopy, CT or PET-CT scans (Refs 13, 14, 15, 18, 28). IHC and molecular diagnostics are emerging as promising and more specific tools to formulate the differential diagnosis, whereas the occurrence of both PAED and synchronous or metachronous colorectal cancer is uncommon, although still possible (Refs 8, 17, 29, 30).…”

Section: Pathogenesis and Clinical Featuresmentioning

confidence: 99%

“…On the other hand, chemotherapy regimens licensed for the advanced NSCLC, including taxanes, gemcitabine or carboplatin, seem to be more effective in terms of response rates (Refs 29, 32).…”

Section: Pathogenesis and Clinical Featuresmentioning

confidence: 99%

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Pulmonary enteric adenocarcinoma: an overview

Palmirotta

Lovero

D’Oronzo

et al. 2020

Expert Rev. Mol. Med.

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Most commonly described as sporadic, pulmonary adenocarcinoma with enteric differentiation (PAED) is a rare variant of invasive lung cancer recently established and recognised by the World Health Organization. This tumour is highly heterogeneous and shares several morphological features with pulmonary and colorectal adenocarcinomas. Our objective is to summarise current research on PAED, focusing on its immunohistochemical and molecular features as potential tools for differential diagnosis from colorectal cancer, as well as prognosis definition and therapeutic choice. PAED exhibits an ‘entero-like’ pathological morphology in more than half cases, expressing at least one of the typical immunohistochemical markers of enteric differentiation, namely CDX2, CK20 or MUC2. For this reason, this malignancy appears often indistinguishable from a colorectal cancer metastasis, making the differential diagnosis laborious. Although standard diagnostic criteria have not been established yet, in the past few years, a number of approaches have been addressed, aimed at defining specific immunohistochemical and molecular signatures. Based on previously published literature, we have collected and analysed molecular and immunohistochemical data on this rare neoplasm, and have described the state of the art on diagnostic criteria as well as major clinical and therapeutic implications. The analysis of data from 295 patients from 58 published articles allowed us to identify the most represented immunohistochemical and molecular markers, as well as major differences between Asian PAEDs and those diagnosed in European/North American countries. The innovative molecular approaches, exploring driver mutations or new gene alterations, could help to identify rare prognostic factors and guide future tailored therapeutic approaches to this rare neoplasm.

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Section: Discussionmentioning

confidence: 99%

Section: Analysis Of Literature Datamentioning

confidence: 99%

Section: Pathogenesis and Clinical Featuresmentioning

confidence: 99%

Section: Pathogenesis and Clinical Featuresmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary enteric adenocarcinoma: an overview

Palmirotta

Lovero

D’Oronzo

et al. 2020

Expert Rev. Mol. Med.

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“…PEAC is a rare pathological type. Between 1 May 2005 and 8 October 2015, <20 PEAC-related references have been recorded by PubMed (www.ncbi.nlm.nih.gov/pubmed) and Wanfang (http://g.wanfangdata.com.cn/) (2,3,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary enteric adenocarcinoma with pancreatic metastasis: A case report

Sun

Wang

et al. 2017

Oncology Letters

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Abstract. Pulmonary enteric adenocarcinoma is a markedly rare pathological type of lung adenocarcinoma. As the pancreas is a relatively uncommon site for metastasis, the present case is even more unusual. A 62-year-old male was admitted to hospital following the identification of masses in the left chest wall, right abdominal wall and right upper limb, but with no respiratory symptoms. Computed tomography (CT) of the chest revealed a lump in the lung and a mass in the left chest wall, and 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake by the lumps was increased. An enhanced abdominal CT revealed a hypodense and homogeneous mass on the head of the pancreas, which was slightly enhanced compared with normal pancreatic tissue. In addition, the 18 F-FDG uptake of the lesion was increased and the standardized uptake value (SUV) delayed was not evidently decreased compared with SUVearly. A number of other abnormal metabolic lesions were also identified using positron emission tomography/CT, whereas no abnormal 18 F-FDG uptake was identified in the gastrointestinal organ. Furthermore, rectocolonoscopy was performed to exclude diagnosis of metastatic colorectal adenocarcinoma. The hematoxylin-and eosin-stained smears of the masses in the right lung and left chest demonstrated an enteric pattern, which shared morphological and immunohistochemical (IHC) features with those of colorectal adenocarcinoma. The IHC detection revealed that the lesions in the right lung were positive for cytokeratin 7 (CK7), and negative for CK20 and thyroid transcription factor 1 (TTF-1), and the expression of caudal type homeobox 2 (CDX2) was weakly positive; the masses in the left chest wall were positive for CK7, negative for TTF-1, and CK20 and CDX2 were weakly expressed.

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A Peculiar Adenocarcinoma

Patel

2018

JAMA Oncol

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A man in his 60s presented with a 1-year history of a mild, dry cough. He was otherwise asymptomatic and had no physical limitations. He had never smoked, and results of his physical examination were normal. Results of complete blood cell counts, basic metabolic panel, and liver function tests were all within normal limits. A chest radiograph revealed a 10 × 9-cm lobulated left lower lobe mass. Examination of a biopsy specimen showed a primary adenocarcinoma with an immunohistochemical profile of CDX2 positive, CK20 positive, TTF-1 negative, and napsin A negative. His EGFR (OMIM 131550), ALK (OMIM 105590), and ROS1 (OMIM 165020) genes were wild type, and results of testing for programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) were 0%. Results of upper gastrointestinal tract endoscopy and colonoscopy did not reveal any evidence of a primary malignant neoplasm. Positron emission tomography showed no evidence of mediastinal lymphadenopathy or extrathoracic disease. Given the patient's excellent performance status, he underwent a mediastinoscopy with left lower lobe lobectomy. Results of postoperative pathologic testing showed a 13-cm adenocarcinoma with similar immunohistochemical markers as in the prior biopsy specimen. Surgical margins were negative for involvement, with no large vessel or perineural invasion seen. Five sampled lymph nodes were negative for involvement. Repeat pathologic interpretation was performed (Figure).

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Pulmonary enteric adenocarcinoma

Cited by 15 publications

References 6 publications

Pulmonary enteric adenocarcinoma: an overview

Pulmonary enteric adenocarcinoma: an overview

Pulmonary enteric adenocarcinoma with pancreatic metastasis: A case report

A Peculiar Adenocarcinoma

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