Pulmonary fibrosis alters gut microbiota and associated metabolites in mice: An integrated 16S and metabolomics analysis

Gong, Gen-cheng; Song, Sheng-ren; Su, Jin

doi:10.1016/j.lfs.2020.118616

Cited by 42 publications

(30 citation statements)

References 45 publications

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“…By analyzing variations in specific intestinal microbes, researchers have constructed models to predict the development of cirrhosis and its complications (Bajaj et al, 2014;Caussy et al, 2019). Recently, a similar microbial prediction model was generated for pulmonary fibrosis (Gong et al, 2021). Therefore, examining the dysbiosis that occurs in intestinal fibrosis and its value in disease prediction may also be worthwhile.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs

Zhan

Liu

et al. 2021

Front. Microbiol.

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Fibrosis is a complex and difficult to elucidate pathological process with no available therapies. Growing evidence implicates intestinal microbiota in the occurrence and development of fibrosis, and the potential mechanisms involved in different organs have been explored in several studies. In this review, we summarize the causative and preventive effects of gut microbiota on intestinal fibrosis, as well as the relationships between gut microbiota and fibrosis in other organs. Interestingly, several colonized microbes are associated with fibrosis via their structural components and metabolic products. They may also play essential roles in regulating inflammation and fibroblast activation or differentiation, which modulates extracellular matrix formation. While the relationships between intestinal fibrosis and gut microbiota remain unclear, lessons can be drawn from the effects of gut microbiota on hepatic, cardiac, nephritic, and pulmonary fibrosis. Various intestinal microbes alterations have been detected in different fibrotic organs; however, the results were heterogeneous. Mechanisms by which the intestinal microbiota regulate fibrotic processes in other organs, such as novel metabolic products or specific microbes, are also discussed. The specific microbiota associated with fibrosis in other organs could instruct future studies aiming to discover prospective mechanisms regulating intestinal fibrosis.

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Section: Discussionmentioning

confidence: 99%

Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs

Zhan

Liu

et al. 2021

Front. Microbiol.

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“…65 Gut microbiota and its metabolites also seem to be associated with pulmonary fibrosis. 85 TLR4 recognizes the damage-associated molecular pattern signal produced by the gut microbiota and activates myeloid differentiation 2/TLR4dependent fibroblasts under the drive of myeloid differentiation 2, resulting in lung fibrosis. 86…”

Section: Gut Dysbiosis and Inflammationmentioning

confidence: 99%

Gut microbiota and bronchopulmonary dysplasia

Yang

Dong

2021

Pediatric Pulmonology

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Bronchopulmonary dysplasia is a relatively common and severe complication of prematurity, and its pathogenesis remains ambiguous. Revolutionary advances in microbiological analysis techniques, together with the growing sophistication of the gut-lung axis hypothesis, have resulted in more studies linking gut microbiota dysbiosis to the occurrence and development of bronchopulmonary dysplasia. The present article builds on current findings to examine the intrinsic associations between gut microbiota and bronchopulmonary dysplasia. Gut microbiota dysbiosis may insult the intestinal barrier, triggering inflammation, metabolic disturbances, and malnutrition, consequences of which might impact bronchopulmonary dysplasia by altering the gut-lung axis. By evaluating the potential mechanisms, new therapeutic targets and potential therapeutic modalities for bronchopulmonary dysplasia can be identified from a microecological perspective.

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“…Besides this, metabolites produced by the gut microbiota, such as lipopolysaccharide, recognized by TLR4 via the pathogen-associated molecule patterns pathway, caused an increase in interleukin-1β, which further activated nuclear factor kappa-B and formed an inflammatory cascade leading to lung injury 43 . Surprisingly, gut microbiota and its metabolites also seem to be associated with pulmonary fibrosis 78 . For example, TLR4 recognizes the damage-associated molecular pattern signal produced by the gut microbiota and activates myeloid differentiation 2/TLR4-dependent fibroblasts under the drive of myeloid differentiation 2, resulting in lung fibrosis 79 .…”

Section: Gut Microbiota Dysbiosis Promotes Inflammationmentioning

confidence: 99%

Gut microbiota and bronchopulmonary dysplasia

Yang

Dong

2021

Preprint

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Bronchopulmonary dysplasia is a relatively common and severe complication of prematurity, and its pathogenesis remains ambiguous. Revolutionary advances in microbiological analysis techniques, together with the growing sophistication of the gut-lung axis hypothesis, have resulted in more studies linking gut microbiota dysbiosis to the occurrence and development of bronchopulmonary dysplasia. The present article builds on current findings to examine the intrinsic associations between gut microbiota and bronchopulmonary dysplasia. The gut microbiota affects bronchopulmonary dysplasia via several potential mechanisms including alteration of the gut-lung axis, promotion of inflammation and the ensuing growth effects, therefore these are also investigated. By evaluating the potential mechanisms, new therapeutic targets and potential therapeutic modalities for BPD can be identified from a microecological perspective.

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Pulmonary fibrosis alters gut microbiota and associated metabolites in mice: An integrated 16S and metabolomics analysis

Cited by 42 publications

References 45 publications

Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs

Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs

Gut microbiota and bronchopulmonary dysplasia

Gut microbiota and bronchopulmonary dysplasia

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