Pulmonary Foreign Body Granulomatosis 11 Years After Injection of a Cosmetic Dermal Filler

Teixeira-Lopes, Francisca; Dias, Ana; Luís, Rita; Ferreira, Leonardo

doi:10.1016/j.arbres.2018.02.024

Cited by 1 publication

(2 citation statements)

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“…While most cases are localized around the injection site, it is exceedingly rare for injected materials to enter the bloodstream and migrate into the lung, forming granulomas. To date, only four such cases have been reported, with the foreign body reaction in our patient being notably more pronounced [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…According to several previous reports, the typical foreign body reaction in granulomatous responses to hyaluronic acid, commonly used in facial cosmetic procedures, is characterized by the presence of multi-nucleated giant cells surrounding amorphous basophilic materials [3][4][5][6][7]. When macrophages fail to remove the foreign substance through phagocytosis, it can transform into multinucleated giant cells, culminating in granuloma formationa manifestation of the foreign body reaction [2]. On occasion, the imaging findings of certain granulomas may mimic malignancy, necessitating confirmatory biopsy.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Foreign Body Granulomatosis after Cosmetic Injection

Kim,

Gil,

Kang

et al. 2024

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Introduction: We occasionally encounter irregular marginated masses discovered incidentally in young individuals. In most cases, further investigations are conducted to assess the presence of a primary malignancy, as these masses often raise suspicions of malignancy. However, rare exceptional cases leave us perplexed. Granulomas arising from common lung infections and those induced by foreign substances can often pose challenge in distinguishing them from lung cancer. Therefore, we aimed to present a case of multiple pulmonary granulomatosis following cosmetic procedure. Case Presentation: A 55-year-old woman visited the hospital after an incidental discovery of an abnormal chest radiograph during a routine health check-up. Subsequent computed tomography (CT) scans showed worrisome lung nodules, leading to biopsies and positron emission tomography CT scans. Histological examination of the biopsied specimens revealed a chronic inflammatory reaction surrounded by multinucleated foreign body giant cells. Upon sharing the biopsy results with the patient and conducting additional history-taking, she had undergone various cosmetic procedures (botox injection, dermal filler treatments, and thread lifts) around the face and neck, approximately 5–6 months ago. It was hypothesized that these cosmetic materials might have led to the observed pulmonary granulomatosis. After 3 months of conservative care, a follow-up CT showed no change in the lesions. Conclusion: We present this case to underscore the importance of considering pulmonary foreign body granulomatosis as a potential differential diagnosis, especially when it closely resembles lung cancer, particularly following cosmetic injections.

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Section: Discussionmentioning

confidence: 99%