Pulmonary function abnormalities in childhood sickle cell disease

Progression and Prognostic Indicators of Bronchial Disease in Children with Sickle Cell Disease

“…Many of these studies showed that unlike a normal nonsmoking individual, where pulmonary function is expected to increase during childhood, in SCD there was a progressive decline in pulmonary function [1,6,12,27]. Our study affirmed this data and showed that average FEV1% of predicted trended below normal with the lowest levels observed during the early adolescent period [1,2,6,12].…”

“…Prior studies have suggested changes in lung function measurements are an early marker of sickle cell lung disease [1,12,27]. Many of these studies showed that unlike a normal nonsmoking individual, where pulmonary function is expected to increase during childhood, in SCD there was a progressive decline in pulmonary function [1,6,12,27].…”

“…Many of these studies showed that unlike a normal nonsmoking individual, where pulmonary function is expected to increase during childhood, in SCD there was a progressive decline in pulmonary function [1,6,12,27]. Our study affirmed this data and showed that average FEV1% of predicted trended below normal with the lowest levels observed during the early adolescent period [1,2,6,12]. This was seen even in the 70 patients where a clearly documented smoking history or exposure was absent and may be a reflection of chronic subclinical inflammation resulting in chronic lung injury.…”

“…Several studies characterize SCD lung manifestations [5,6,[8][9][10][11]. The presence of a restrictive lung pattern have been reported in adults [2,6,[12][13][14][15][16]]. An obstructive pattern has been reported in pediatric studies, with increased prevalence over time approximating a 3 % loss in forced expiratory volume in one second (FEV1)% of predicted/ year [7].…”

Airway Hyperresponsiveness in Children With Sickle Cell Anemia

“…4,5,7,8 Although these data imply that asthma has a signifi cant disease-modifying effect in children with SCA, characteristics of SCA, such as episodes of acute chest syndrome, 9 pulmonary function abnormalities, [10][11][12] and chronic respiratory symptoms, add complexity to the diagnosis of asthma. Thus, it is not clear if descriptions of asthma in these children refl ect the presence of two distinct comorbid conditions or an asthma-like phenotype secondary Background: The high prevalence of airway hyperresponsiveness (AHR) among children with sickle cell anemia (SCA) remains unexplained.…”