Pulmonary Function after Lymphography

White, Ralph; Webb, John A.; Tucker, Audrey K.; Foster, Krislyn

doi:10.1136/bmj.4.5895.775

Cited by 5 publications

(1 citation statement)

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“…This has generally been done in patients with 'borderline' large mediastinal adenopathy who would be treated with radiation therapy alone if the laparotomy was negative. Because there are also potential hazards employing lymphangiography in patients with large mediastinal disease an abdominal CT should suffice in these high risk situations (White et al. 1973;Fallat et al.…”

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confidence: 99%

Mediastinal Hodgkin's disease: Significance of mediastinal involvement in early stage Hodgkin's disease

Mauch

Hellman

1984

Hematological Oncology

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A and I1 A patients with supradiaphragmatic Hodgkin's disease were treated at the Joint Center for Radiation Therapy. Patients received 3600-4400 rad to mantle and para-aortic-splenic pedicle regions. Median follow-up was 56 months (30-96). Fourteen patients developed relapsing Hodgkin's disease and three patients died of possible treatment-related causes, two with acute myo-cardial infarctions and one with radiation pneumonitis. Patients with media-stinal enlargement greater than one third of the chest diameter have a significantly higher risk (p < 0.01) of developing relapse (9 of 18) than patients with lesser or no mediastinal disease (5 of 93). Of the 18 patients with large media-stinal disease, six relapsed in the mediastinum and two in the lung. There continue to be no pelvic extensions in the entire group. There is a 92% relapse-free and 97% overall survival in the 93 patients without extensive mediastinal disease. We continue to recommend mantle and para-aortic-splenic pedicle irradiation for these patients. In view of the large number of relapses in patients with extensive mediastinal disease, we are now treating this subgroup of patients with MOPP chemotherapy in addition to mantle and para-aortic irradiation.

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confidence: 99%