Pulmonary Function and Arterial Stiffness in Chronic Heart Failure

Li, Li; Hu, Bangchuan; Gong, Shijin; Yu, Yihua; Dai, Hehua; Yan, Jing

doi:10.1155/2016/5478394

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…Chronic obstructive pulmonary disease (COPD) is known to often coexist in patients with heart failure and is considered to be a risk of adverse outcomes in patients with heart failure. CAVI is negatively associated with forced expiratory volume at 1.0 s in patients with heart failure [154,155]. Furthermore, CAVI increases with the grades of severity of COPD in symptomatic patients of heart failure [156].…”

Section: Cavi and Prognosis Of Heart Failurementioning

confidence: 99%

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Namba

Masaki

Takase

et al. 2019

IJMS

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Arterial stiffness is an age-related disorder. In the medial layer of arteries, mechanical fracture due to fatigue failure for the pulsatile wall strain causes medial degeneration vascular remodeling. The alteration of extracellular matrix composition and arterial geometry result in structural arterial stiffness. Calcium deposition and other factors such as advanced glycation end product-mediated collagen cross-linking aggravate the structural arterial stiffness. On the other hand, endothelial dysfunction is a cause of arterial stiffness. The biological molecular mechanisms relating to aging are known to involve the progression of arterial stiffness. Arterial stiffness further applies stress on large arteries and also microcirculation. Therefore, it is closely related to adverse outcomes in cardiovascular and cerebrovascular system. Cardio-ankle vascular index (CAVI) is a promising diagnostic tool for evaluating arterial stiffness. The principle is based on stiffness parameter β, which is an index intended to assess the distensibility of carotid artery. Stiffness parameter β is a two-dimensional technique obtained from changes of arterial diameter by pulse in one section. CAVI applied the stiffness parameter β to all of the arterial segments between heart and ankle using pulse wave velocity. CAVI has been commercially available for a decade and the clinical data of its effectiveness has accumulated. The characteristics of CAVI differ from other physiological tests of arterial stiffness due to the independency from blood pressure at the time of examination. This review describes the pathophysiology of arterial stiffness and CAVI. Molecular mechanisms will also be covered.

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Section: Cavi and Prognosis Of Heart Failurementioning

confidence: 99%

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Namba

Masaki

Takase

et al. 2019

IJMS

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“…A history of heart failure, neuromuscular disease, and independent physical activity affected the spirometric value to almost the same extent as that of age ( Figure 1 ). Although the underlying mechanism involving heart failure is not fully understood, possible explanations include arterial stiffness, severity of mitral valve regurgitation, pulmonary vascular congestion, and enlargement of heart size (9) , (10) . Impaired muscle strength is one of the most frequent and persistent consequences of aging and neuromuscular disease.…”

Section: Discussionmentioning

confidence: 99%

Impact of Age-related Diseases on Pulmonary Function Tests in Older Japanese Adults: A Cross-sectional Pilot Study

Matsuo¹

2020

JMA J

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Introduction: A widely used reference range for pulmonary function testing was derived from middle-aged, healthy, non-smoking adults in Japan. This study examined the effect of age-related diseases on pulmonary function tests for older Japanese adults. Methods: All patients aged ≥65 years who underwent spirometry before general and orthopedic surgeries in Itoigawa General Hospital (Niigata, Japan) from January 2014 to June 2019 were identified, and their charts were reviewed. Results: This study included 1050 Japanese patients (median age: 75 years). The median spirometric values of vital capacity, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC in all patients were 2.66 L [interquartile range; 2.24, 3.25], 2.57 L [2.13, 3.13], 1.98 L [1.66, 2.37], and 77.5% [72.2, 81.9], respectively. Multiple regression analyses revealed that spirometric values were significantly affected by age, body height, sex, smoking status, social dependency, dyslipidemia, diabetes, history of heart failure, peripheral artery disease, end-stage renal disease, neuromuscular disease, and psychiatric disorders. Male sex and height were positively correlated with FVC and FEV1. Other factors, such as a history of heart failure, neuromuscular disease, and independent physical activity, were negatively correlated with FVC and FEV1 to almost the same extent as that of age. Conclusions: These data will provide clinically useful information to accurately interpret pulmonary function test results in older Japanese adults.

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“…The hypoxic stress in lung tissues and disorganized pulmonary vascular peds reproduced myocardial damage [47]. The lung dysfunction may lead to decrease respiratory mechanics, impaired gas exchange and cardiovascular abnormalities [48], increased arterial stiffness, the marker of heart failure [49].…”

Section: Discussionmentioning

confidence: 99%

Markers of Heart, Lung and Dorsal Aorta Damage of Mother Rats and Their Neonates Post Therapeutic Treatment with Doxorubicin, Cisplatin and 5-Flurouracil

El-Ghawet¹,

Gadallah²,

El‐Mansi³

et al. 2017

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Aim: Recently, there is an increased average of developing cancers. Though, the chemotherapeutic-treatment is unfavorable during pregnancy due to its harmful effects on developing fetuses, physicians have two ways to minimize these effects either by termination of the pregnancy or minimizing its side effects. The present work aimed to illustrate the susceptibility of cardiac, lung and dorsal aorta function to the widely applicable drugs doxorubicin and cisplatin as well as 5-flurouracil. Materials and Methods: Mother albino rats were arranged into four-groups (control, doxorubicin, cisplatin and 5-flurouracil-treated groups). Each pregnant rat received intraperitoneal administration of 0.2 mg/kg body weight at 10 th and 14 th day of gestation and sacrificed at parturition (two doses). At parturition, serum of mother rats used to assess troponin I, heat shock protein 70, 8-hydroxydeoxyguanosine, vascular endothelial growth factor and adhesion molecules (ICAM-1 & VCAM-1). Isoenzyme electrophoresis of alkaline and acid phosphatases, glucose-6-phosphate dehydrogenase and lactic dehydrogenase were estimated in serum, myocardium and dorsal aorta of mother rats. The myocardium and lung were processed for histopathological investigations for both mothers and their offspring. Single strand (comet assay) and double strand DNA damage were carried out in heart and dorsal aorta of mother rats. Results: The present finding revealed that there are detected alterations of myocardial markers and lung amino acid metabolism as well as disruption of myocardial isoenzymes. 83Chinese Medicine DNA damage of myocardium and dorsal aorta were observed. Conclusions: The authors concluded that the metabolic activity of heart and lung is highly susceptible to doxorubicin and cisplatin treatment compared to 5-flurouracil and the therapeutic doses must be degraded.

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Pulmonary Function and Arterial Stiffness in Chronic Heart Failure

Cited by 7 publications

References 43 publications

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Impact of Age-related Diseases on Pulmonary Function Tests in Older Japanese Adults: A Cross-sectional Pilot Study

Markers of Heart, Lung and Dorsal Aorta Damage of Mother Rats and Their Neonates Post Therapeutic Treatment with Doxorubicin, Cisplatin and 5-Flurouracil

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