Pulmonary Function and Exercise-associated Changes with Chronic Low-Level Paraquat Exposure

Schenker, Marc B.; Stoecklin, Maria T.; Lee, Ki-Young; Lupercio, Rafael; Zeballos, R. Jorge; Enright, Paul; Hennessy, Tamara E.; Beckett, Laurel A.

doi:10.1164/rccm.200403-266oc

Cited by 56 publications

(52 citation statements)

References 33 publications

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“…The decreased aerobic performance was associated with increased oxygen consumption and reduced this study has already been validated as a model of pulmonary fibrosis (Akahori and Oehme, 1983;Satomi et al, 2004Satomi et al, , 2006Satomi et al, , and 2007; in such way, the increase in collagen production in the intoxicated animals was to be expected. However, to the best of our knowledge, up to the present date no studies have been carried out to invesaerobic performance, energy expenditure and mechaniing exercise tests (Schenker et al, 2004;Dalvie et al, 1999;Castro-Gutiérrez et al, 1997;Howard et al, 1981) and these publications reported no changes in spirometric variables during the tests despite repeated exposure by imaging tests. Moreover, these studies were restricted to evaluating spirometric variables during physical effort and none investigated the impact of consecutive exposure aerobic performance, energy expenditure and mechanical tion.…”

Section: Discussionmentioning

confidence: 93%

“…The most common cause of death from PQ poisoning is respiratory failure due to an oxidative insult to the pulmonary parenchyma with subsequent pulmonary fibrosis (Tomita et al, 2007;Kim et al, 2006;Orito et al, 2004;Schenker et al, 2004). According to previous study (Heindl et al, 2001), there is marked sympathetic activation in patients with chronic respiratory failure associated -sequences for respiratory muscle function.…”

Section: Introductionmentioning

confidence: 99%

“…Dalvie et al (1999) evaluated the possible effects of PQ spraying among workers on deciduous fruit farms in the Westbetween measures of long term exposure to PQ and arterial oxygen desaturation during exercise independent of -ing with PQ under usual field conditions is associated with abnormal exercise physiology in a dose dependent fashion independent of recent exposure and acute poisoning events. Furthermore, Schenker et al (2004) studied pulmonary function and exercise-associated changes with chronic low-level PQ exposure and also observed the association of PQ exposure with oxygen desaturation suggesting that PQ may be associated with subclinical gas exchange abnormalities.…”

Section: Introductionmentioning

confidence: 99%

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Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats

et al. 2009

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-Rats exposed to the quaternary herbicide paraquat (PQ) exhibit oxidative stress and lung injury. In the present study, we investigated the effect of multiple exposures to PQ on aerobic performance during progressive exercise on a treadmill in rats. PQ was dissolved in saline (SAL) (10 mg/ml) and administered intraperitoneally 7 mg/kg body wt to Wistar rats (n = 5) once a week for one month. Control rats received SAL (0.7 ml/kg body wt., intraperitoneally, n = 5) over the same time period. The animals were submitted to aerobic evaluation on a treadmill using a progressive protocol until fatigue prior to the removed and divided in two groups: PQ and SAL for histopathological analysis. The animals exposed to -gen consumption during exercise in comparison to the controls forty days after the last dose of PQ. Lung -parenchyma were higher in PQ compared to SAL. In conclusion, multiple exposures to PQ induce pulmoof exercise in rats.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats

et al. 2009

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“…Beberapa hasil penelitian menyimpulkan adanya hubungan antara paparan pestisida dengan prevalensi bronkhitis kronis dengan nilai OR = 1,91-15,92 8,9,10 dan berhubungan dengan kejadian sesak nafas dan mengi dengan nilai OR = 1,2-6,7 11,12 . Hernandez menemukan bahwa dari 89 penyemprot dengan paparan herbisida bipyridilium mengalami penurunan kapasitas difusi paru, dan bahwa paparan terhadap insektisida neonicotinoid terkait dengan penurunan volume paru (kapasitas total paru, volume residu, dan kapasitas fungsional residu).…”

Section: Pendahuluanunclassified

Pengaruh Teknik Aplikasi Pestisida terhadap Derajat Keparahan Penyakit Paru Obstruktif Kronis (PPOK) pada Petani

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et al. 2017

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ABSTRAKLatar Belakang: Kabupaten Grobogan sebagai sentra utama pertanian di Jawa Tengah yang banyak menggunakan pestisida mengalami peningkatan kasus PPOK sejak tahun 2010, dimana etiologi PPOK berasal dari gene-enviroment interaction dan salah satu penyakit akibat kerja utama terkait paparan zat toksik di tempat kerja. Persentase terbesar (71%) penderita PPOK berdasarkan data rekam medis 2009-2012 di RS PKU Muhammadiyah Gubug Kabupaten Grobogan adalah petani. Penelitian ini bertujuan menganalisis pengaruh teknik aplikasi pestisida terhadap derajat keparahan PPOK pada petani. Materi dan Metode: Penelitian ini merupakan studi kasus kontrol yang dilakukan di Kabupaten Grobogan dengan 100 petani sebagai responden yang dipilih secara purposive. Pengumpulan data melalui wawancara, observasi, pemeriksaan klinis dan spirometri. Analisis data menggunakan uji korelasi rank spearman dan regresi logistik ordinal. Hasil: Hasil penelitian menunjukkan bahwa 23% responden termasuk PPOK Sedang, 17% PPOK sangat berat, 7% PPOK ringan dan 3% PPOK berat. Sebagian besar responden menyatakan lama penyemprotan pestisida lebih dari 5 jam per hari (69%), seminggu lebih dari 1 kali (72%), waktu penyemprotan pada pagi/sore hari (95%). Sebagian besar responden (85%) sering melakukan penyemprotan pestisida tanpa memperhatikan arah angin dan melakukan penyemprotan pestisida melawan arah angin (42%), saat angin kencang (36%) dan menggunakan baju/kain yang sudah terpapar pestisida untuk menyeka keringat (42%). Hasil uji statistik menunjukkan ada hubungan signifikan antata derajat keparahan PPOK dengan lama paparan pestisida per hari (p value=0,003) dan kesesuaian arah penyemprotan pestisida (0,000). Ada pengaruh signifikan lama paparan pestisida per hari (p value=0,004) dan kesesuaian arah penyemprotan pestisida (p value=0,000) terhadap derajat keparahan PPOK. Simpulan: Temuan baru dalam penelitian ini adalah teknik aplikasi pestisida yang terbukti berpengaruh terhadap derajat PPOK adalah lama paparan per hari dan kesesuaian arah penyemprotan pestisida. Implikasi hal tersebut terhadap kesehatan masyarakat yaitu diperlukannya sosialisasi prosedur kerja aman petani dalam menggunakan pestisida dengan menyempurnakan teknik aplikasi pestisida secara baik dan benar dalam pencegahan PPOK. Disarankan lama paparan pestisida disarankan tidak melebihi 5 jam per hari dan dihindarkan penyemprotan pestisida melawan arah angin.

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“…The PECOS (Prairie Echo) study, conducted in 2000 in rural Saskatchewan, showed an increased prevalence of bronchitis (OR 4.3, 95% CI 2.0-9.4) and respiratory symptoms (cough, chronic phlegm, wheezing and shortness of breath) (OR 2.4, 95% CI 1.1-5.2) among farmers' wives only [36]. In 2004, SCHENKER et al [37] studied paraquat exposure on banana, coffee and oil palm tree plantations in male farm workers in Costa Rica. A cumulative index of exposure, taking into account the history of tasks and protective equipment, was calculated.…”

Section: Studies On Agricultural Workersmentioning

confidence: 99%

Occupational exposure to pesticides and respiratory health

et al. 2015

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This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.Among the 15 cross-sectional studies focusing on respiratory symptoms and agricultural pesticide exposure, 12 found significant associations with chronic cough, wheeze, dyspnoea, breathlessness or chest tightness. All four studies on asthma found a relationship with occupational exposure, as did all three studies on chronic bronchitis. The four studies that performed spirometry reported impaired respiratory function linked to pesticide exposure, suggestive of either obstructive or restrictive syndrome according to the chemical class of pesticide.12 papers reported results from cohort studies. Three out of nine found a significant relationship with increased risk of wheeze, five out of nine with asthma and three out of three with chronic bronchitis. In workers employed in pesticide production, elevated risks of chronic obstructive pulmonary disease (two studies out of three) and impaired respiratory function suggestive of an obstructive syndrome (two studies out of two) were reported.In conclusion, this article suggests that occupational exposure to pesticides is associated with an increased risk of respiratory symptoms, asthma and chronic bronchitis, but the causal relationship is still under debate. @ERSpublications A review of occupational (agricultural and industry) exposure to pesticides and associated respiratory health effects http:///ow.ly/M09Gc

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Pulmonary Function and Exercise-associated Changes with Chronic Low-Level Paraquat Exposure

Cited by 56 publications

References 33 publications

Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats

Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats

Pengaruh Teknik Aplikasi Pestisida terhadap Derajat Keparahan Penyakit Paru Obstruktif Kronis (PPOK) pada Petani

Occupational exposure to pesticides and respiratory health

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