Pulmonary function during the first year of life in healthy infants born prematurely

Merth, I. T.; Winter, Peter de; Borsboom, Gerard; Quanjer, P. H.

doi:10.1183/09031936.95.08071141

Cited by 23 publications

(20 citation statements)

References 25 publications

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“…Reported values are those of one or the mean of up to four assessments (on average two assessments). The single determination standard deviation was 9% [31].…”

Section: Mixing Index (Mi)mentioning

confidence: 99%

“…An attractive feature of using an infant spirometer is that it allows concurrent measurement of Crs, FRCHe and MI [31]. TEPPER et al [34] were the first to apply weighted spirometry for measuring Crs in infants [34].…”

Section: Discussionmentioning

confidence: 99%

“…equilibration time at least 5 min, no leak detected, behaviourally quiet sleep suggested by stable end-expiratory level with regular frequency and tidal volume). The single determination standard deviation was 8% [31]. Volumes were corrected to body temperature and ambient pressure, and saturated with water vapour (BTPS) conditions.…”

Section: Methodsmentioning

confidence: 99%

“…Reported values are means of two repeated measurements. The single determination standard deviation was 13 mL·kPa -1 [31]. Volume and pressure changes were calibrated before and after each testing session.…”

Section: Respiratory System Compliance (Crs)mentioning

confidence: 99%

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Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Merth¹,

Winter²,

Zonderland³

et al. 1997

Eur Respir J

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The clinical and radiological picture of bronchopulmonary dysplasia (BPD) following prolonged mechanical ventilation and administration of high concentrations of oxygen for hyaline membrane disease (HMD), described in 1967, has become relatively rare [1]. With the advent of: antenatal corticosteroids; more gentle application of mechanical ventilation; judicious administration of fluids, nutrients and oxygen; early closure of a patent ductus arteriosus; and surfactant administration, a milder form is now more prevalent [2]. The term neonatal chronic lung disease (NCLD) is currently preferred [3]. Mostly because of the increased number of surviving infants with shorter gestation [4,5], the estimated incidence of NCLD of about 30% of all ventilated newborns has not changed since the original description of BPD [6]. NCLD is now the most prevalent chronic respiratory disorder of infancy.Expectations of a decrease in the incidence of NCLD as a result of new treatments like surfactant administration to the high-risk group [7] and more sophisticated artificial ventilation [8], have not as yet been met, although new techniques are being developed to meet the challenge [9]. Moreover, a population of very small preterm babies has recently been recognized who initially have no or only mild pulmonary disease requiring no respiratory support, but subsequently develop NCLD [3,5,10], suggesting that respiratory support is not a prerequisite for developing NCLD [6,11,12].Studies published so far have described abnormal pulmonary mechanics in infants who developed NCLD following ventilatory treatment for HMD [13][14][15][16][17][18][19][20]. Abnormal respiratory function is frequently seen as a consequence of lung damage associated with the level of treatment. On the other hand, therapeutic intervention is likely to be necessary if immaturity or prematurity are associated with compromised respiratory function at birth [21]. Only one study included both ventilated and nonventilated preterm infants [17]; in that study asymptomatic infants had normal lung function by the age of 1 yr. At school age in children born prematurely, airway diameter, as inferred from forced expiratory flows, was related only to birth weight and not to the level of respiratory therapy at birth [22,23].In the present study we analysed the association between a history of HMD, difference in ventilatory support We conclude that birth weight is the major determinant of the development of neonatal chronic lung disease. At 6 and 12 months corrected age, the abnormal pulmonary function is not associated with prior hyaline membrane disease.

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“…Reported values are those of one or the mean of up to four assessments (on average two assessments). The single determination standard deviation was 9% [31].…”

Section: Mixing Index (Mi)mentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Respiratory System Compliance (Crs)mentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Merth¹,

Winter²,

Zonderland³

et al. 1997

Eur Respir J

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show abstract

“…Some studies did not detect any significant differences in FRC either when comparing ''healthy'' term and preterm infants, 58,80 or when relating results from healthy preterm infants to published reference equations for FRC He . 68 In contrast, Hjalmarson and Sandberg reported significantly reduced FRC N2 in healthy preterm infants compared to term neonates (data only normalized for weight at test).…”

Section: The Extent To Which Functional Findings Can Be Related To Pamentioning

confidence: 99%

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Hülskamp¹,

Pillow²,

Dinger³

et al. 2005

Pediatric Pulmonology

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Summary. This is the second paper in a review series that will summarize available data and discuss the potential role of lung function testing in infants and young children with acute neonatal respiratory disorders and chronic lung disease of infancy. The current paper addresses the expansive subject of measurements of lung volume using plethysmography and gas dilution/ washout techniques. Following orientation of the reader to the subject area, we focus our comments on areas of inquiry proposed in the introductory paper to this series. The quality of the published literature is reviewed critically, and recommendations are provided to guide future investigation in this field. Measurements of lung volume are important both for assessing growth and development of lungs in health and disease, and for interpreting volume-dependent lung function parameters such as respiratory compliance, resistance, forced expiratory flows, and indices of gas-mixing efficiency. Acute neonatal lung disease is characterized by severely reduced functional residual capacity (FRC), with treatments aimed at securing optimal lung recruitment. While FRC may remain reduced in established chronic lung disease of infancy, more commonly it becomes normalized or even elevated due to hyperinflation, with or without gas-trapping, secondary to airway obstruction. Ideally, accurate and reliable bedside measurements of FRC would be feasible from birth, throughout all phases of postnatal care (including assisted ventilation), and during subsequent long-term follow-up. Although lung volume measurements in extremely preterm infants were described in a research environment, resolution of several issues is required before such investigations can be translated into routine clinical monitoring. Pediatr

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Bronchopulmonary dysplasia: Pre- and postnatal influences and outcome

Hislop¹

1997

Pediatr. Pulmonol.

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Pulmonary function during the first year of life in healthy infants born prematurely

Cited by 23 publications

References 25 publications

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Lung Function Tests in Neonates and Infants with Chronic Lung Disease of Infancy: Functional Residual Capacity

Bronchopulmonary dysplasia: Pre- and postnatal influences and outcome

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