Pulmonary function in cured pulmonary tuberculosis cases

Gupta, Mallika; Bagri, Sharad; Garg, Ankur; Singh, Devendra Kumar; Choudhary, Prashant; Sahni, Subah

doi:10.1016/j.ijtb.2021.08.024

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…Decreases in DLco can occur even in patients with normal spirometry and could be a better tool for lung function evaluation in PTLD patients. 36 Furthermore, they can also correlate with cardiopulmonary exercise testing and predict oxygen consumption when that test is unavailable. 37 …”

Section: Assessment Of Ptldmentioning

confidence: 99%

“…(23) Reduções da DLco podem ocorrer mesmo em pacientes com espirometria normal e podem ser uma ferramenta melhor para a avaliação da função pulmonar em pacientes com DPPT. (36) Além disso, também podem se correlacionar com o teste de exercício cardiopulmonar e predizer o consumo de oxigênio quando esse teste não estiver disponível. (37) Assim como para a avaliação de outras doenças pulmonares e cardíacas, o teste de caminhada de seis minutos (TC6) auxilia na avaliação de pacientes com DPPT.…”

Section: Testes De Função Pulmonarunclassified

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Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease

Rossato Silva1,

Paula Santos2,3,

Visca4,5

et al. 2023

J Bras Pneumol.

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Historically, all efforts against tuberculosis were focused on rapid diagnosis and effective treatment to break the chain of transmission of Mycobacterium tuberculosis. However, in the last few years, more and more evidence has been found on the dramatic consequences of the condition defined as post-tuberculosis lung disease (PTLD). Approximately one third of patients surviving pulmonary tuberculosis face considerable ongoing morbidities, including respiratory impairment, psychosocial challenges, and reduced health-related quality of life after treatment completion. Given the important global and local burden of tuberculosis, as well as the estimated burden of PTLD, the development of a consensus document by a Brazilian scientific society-Sociedade Brasileira de Pneumologia e Tisiologia (SBPT)-was considered urgent for the prevention and management of this condition in order to allocate resources to and within tuberculosis services appropriately and serve as a guide for health care professionals. A team of eleven pulmonologists and one methodologist was created by the SBPT to review the current evidence on PTLD and develop recommendations adapted to the Brazilian context. The expert panel selected the topics on the basis of current evidence and international guidelines. During the first phase, three panel members drafted the recommendations, which were divided into three sections: definition and prevalence of PTLD, assessment of PTLD, and management of PTLD. In the second phase, all panel members reviewed, discussed, and revised the recommendations until a consensus was reached. The document was formally approved by the SBPT in a special session organized during the 2023 SBPT Annual Conference.

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Section: Assessment Of Ptldmentioning

confidence: 99%

Section: Testes De Função Pulmonarunclassified

Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease

Rossato Silva1,

Paula Santos2,3,

Visca4,5

et al. 2023

J Bras Pneumol.

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“…Spinal infection is a common symptom characterized by constant back pain, which is worse at night. Spinal infections may affect the vertebrae, discs, spinal canal, and paraspinal soft tissues [9].…”

Section: Introductionmentioning

confidence: 99%

Novelty of Physiotherapy Protocols in a Classic Case of Extrapulmonary Tuberculosis in a 35-Year-Old Male Patient: A Case Report

Wanjari,

Lalwani,

Tiwari

2024

Cureus

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Tuberculosis is the most frequent cause of death, specifically caused by a single infectious agent, Mycobacterium tuberculosis. There are two types of tuberculosis: pulmonary tuberculosis and extrapulmonary tuberculosis. Patients with extrapulmonary tuberculosis often have reduced lung function due to the disease's structural abnormalities, which also significantly impair their quality of life. The suggested standard of care for the treatment of extrapulmonary tuberculosis patients is pulmonary rehabilitation. A 35-year-old male patient who complained of shortness of breath, dry cough, and on-and-off fever diagnose with extrapulmonary tuberculosis was the subject of the case study. The patient had extrapulmonary tuberculosis with a history of pleural effusion, which was managed with proper medications. After increasing symptoms of the disease, the patient was referred for pulmonary rehabilitation. Physiotherapy protocol includes breathing exercises, relaxation techniques, and mobility exercises for the upper limb and lower limb. Effective physical rehabilitation was necessary to minimize complications and allow him to resume daily activities. Several outcome measures, like the dyspnea scale, visual analog scale, six-minute walk test, and World Health Organization-Quality of Life (WHO-QOL) questionnaire, were used to monitor the patient's progress during rehabilitation. The benefits of physiotherapy protocols emphasize the need for tailored approaches to addressing individual patient needs for comprehensive recovery as it significantly enhances clinical, physical, psychosocial, and overall quality of life, making it crucial for patients with extrapulmonary tuberculosis. The protocols are beneficial to improve exercise capacity, muscle force, symptoms such as dyspnea, cough, and health-related quality of life in these patients. In this study, the focus was more on breathing exercises such as segmental breathing exercises for lung expansion and increasing air entry in the lungs followed by improving functional capacity and strength.

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“…The majority of TB cases in clinical practice are pulmonary tuberculosis (PTB), accounting for 80–90% ( Dheda et al, 2017 ). PTB can lead to lung granuloma formation as well as tissue liquefaction and cavity development ( Gupta et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Causal associations of gut microbiota and pulmonary tuberculosis: a two-sample Mendelian randomization study

Lu,

Xu,

Guo

et al. 2024

Front. Microbiol.

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BackgroundThe prevalence of pulmonary tuberculosis (PTB) as an infectious disease continues to contribute significantly to global mortality. According to recent studies, the gut microbiota of PTB patients and healthy controls (HCs) show significant disparities. However, the causal relationship between them has yet to be elucidated.MethodsWe conducted a study using Mendelian Randomization (MR) to explore the potential causal link between gut microbiota and pulmonary tuberculosis (PTB). The summary statistics of the gut microbiota were acquired from the MiBioGen consortium, while data on PTB were sourced from pheweb.jp. A range of statistical methodologies were employed to evaluate causality, encompassing inverse variance weighting (IVW), MR-Egger, weighted median (WM), weighted model, and simple model. We utilized instrumental variables (IVs) that have a direct causal relationship with PTB to annotate SNPs, aiming to discover the genes harboring these genetic variants and uncover potential associations between host genes and the microbiome in patients with PTB.ResultsAmong the 196 bacterial traits in the gut microbiome, we have identified a total of three microbiomes that exhibit a significant association with PTB. The occurrence of Dorea (P = 0.0458, FDR-adjusted P = 0.0458) and Parasutterella (P = 0.0056, FDR-adjusted P = 0.0168) was linked to an elevated risk of PTB, while the presence of Lachnoclostridium (P = 0.0347, FDR-adjusted P = 0.0520) demonstrated a protective effect against PTB. Our reverse Two-Sample Mendelian Randomization (TSMR) analysis did not yield any evidence supporting the hypothesis of reverse causality from PTB to alterations in the intestinal flora.ConclusionWe have established a connection between the gut microbiota and PTB through gene prediction analysis, supporting the use of gut microecological therapy in managing PTB and paving the way for further understanding of how gut microbiota contributes to PTB’s development.

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Pulmonary function in cured pulmonary tuberculosis cases

Cited by 4 publications

References 5 publications

Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease

Brazilian Thoracic Association recommendations for the management of post-tuberculosis lung disease

Novelty of Physiotherapy Protocols in a Classic Case of Extrapulmonary Tuberculosis in a 35-Year-Old Male Patient: A Case Report

Causal associations of gut microbiota and pulmonary tuberculosis: a two-sample Mendelian randomization study

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