Pulmonary Function in Patients with Diabetes Mellitus

Benbassat, Carlos; Stern, Ervin; Kramer, Mordechai; Lebzelter, Joseph; Blum, Ilana; Fink, Gershon

doi:10.1097/00000441-200109000-00003

Cited by 90 publications

(68 citation statements)

References 21 publications

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“…However, these findings were not confirmed by subsequent studies, which found nearly normal lung volumes in diabetic patients, similar as in control subjects [61]. This led to the rejection of a correlation between lung function and glycemic control or duration of diabetes [30,31].…”

Section: Lung Volumesmentioning

confidence: 86%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

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■ AbstractSeveral abnormalities of the respiratory function have been reported in patients with type 1 and type 2 diabetes. These abnormalities concern lung volume, pulmonary diffusing capacity, control of ventilation, bronchomotor tone, and neuroadrenergic bronchial innervation. Many hypotheses have emerged, and characteristic histological changes have been described in the "diabetic lung", which could explain this abnormal respiratory function. Given the specific abnormalities in diabetic patients, the lung could thus be considered as a target organ in diabetes. Although the practical implications of these functional changes are mild, the presence of an associated acute or chronic pulmonary and/or cardiac disease could determine severe respiratory derangements in diabetic patients. Another clinical consequence of the pulmonary involvement in diabetes is the accelerated decline in respiratory function. The rate of decline in respiratory function in diabetics has been found to be two-to-three times faster than in normal non-smoking subjects, as reported in longitudinal studies. This finding, together with the presence of anatomical and biological changes similar to those described in the aging lung, indicates that the "diabetic lung" could even be considered a model of accelerated aging. This review describes and analyses the current insight into the relationship of diabetes and lung disease, and suggests intensifying research into the lung as a possible target organ in diabetes.

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Section: Lung Volumesmentioning

confidence: 86%

The Diabetic Lung - A New Target Organ?

Pitocco

Fuso²,

Conte³

et al. 2012

Rev Diabet Stud

146

112

View full text Add to dashboard Cite

show abstract

“…Contradicting to our study along with other above mentioned study Benbassat et al in his study published in 2001 title "pulmonary function in patient with diabetic mellitus" showed no change in spirometric values in diabetic and non diabetic patient. But, his study had very few test subjects which was 27 and the mean age group was also less (48 years) [24].…”

Section: Discussionmentioning

confidence: 96%

Diabetic: A Comparative Study

Dhungel

Wassem

Dhungel³

2017

Janaki Med. Coll. J. Med. Sci.

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Background and Objectives: Type II diabetes mellitus (DM) is particularly common medical disorder and is leading cause of morbidity worldwide. The complication of DM is due to micro or macro vascular damage. The presence of an extensive microvascular circulation and abundant connective tissue in the lungs raises the possibility that lung tissue may be a target organ in diabetic patients and thus pulmonary function test can be affected by DM. This study was designed to compare pulmonary function test between Type II diabetic and non-diabetic individuals; and, with the duration of DM. Material and Methods:This cross sectional comparative study was conducted at King Edward Medical University, Lahore Pakistan. Total sample consist of 91 diabetic and 91 non-diabetic grouped as group A and group B. FEV1, FVC, FEV1/FVC ratio, and PEFR were compared within two groups and with the duration of DM.Results: Total 182 sample with mean age 53.15.90 years, with 91(50%) male and 91(50%) female. Group A and B had 91(50%) sample each. Mean value of FVC, FEV1 and PEFR showed statistically significant difference among the both group. Mean of FVC decreases significantly with the increasing duration of DM; although, is not significant with FEV1, FEV1/FVC ratio, and PEFR. Conclusion:Diabetic group showed significantly impaired pulmonary functions test as FEV1, FVC, and PEFR as compare to non-diabetic group.

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“…Free fatty acids have a detrimental effect on the endothelial function of the vasculature due to mechanisms such as oxidative stress and this again leads to vascular dysfunction and microangiopathies. 5,8 As with the pulmonary function, the major contributory factor that may lead to pulmonary dysfunction is thought to be microangiopathic changes in the alveolar capillaries and arterioles. Other mechanisms are also thought to play a role.…”

Section: Discussionmentioning

confidence: 99%