Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis

Kariya, Shin; Okano, Mitsuhiro; Oto, Takahiro; Higaki, Toru; Makihara, Seiichiro; Tamano, Haruna; Nishizaki, Kazunori

doi:10.1017/s0022215114000450

Cited by 22 publications

(28 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the levels of IL-5 in nasal secretion in the middle meatus were significantly correlated with lung function changes. 75 We have also demonstrated in another study that obstructive lung dysfunction was more impaired in non-asthmatic patients with CRSwNP with peripheral blood eosinophilia (eosinophil percentage to total leukocyte equal or more than 5%) than in those without eosinophilia, especially in elderly patients aged 60 years old or more. 76 Similar explanations as those put forward to account for the relationship between AR and asthma have been proposed to explain why the presence of CRS induces lower airway inflammation and dysfunction.…”

Section: Presence and Characterization Of Comorbidity Of Chronic Rhinsupporting

confidence: 52%

Association and management of eosinophilic inflammation in upper and lower airways

Okano

Kariya

Ohta

et al. 2015

Allergology International

View full text Add to dashboard Cite

This review discussed the contribution of eosinophilic upper airway inflammation includes allergic rhinitis (AR) and chronic rhinosinusitis (CRS) to the pathophysiology and course of asthma, the representative counterpart in the lower airway. The presence of concomitant AR can affect the severity of asthma in patients who have both diseases; however, it is still debatable whether the presence of asthma affects the severity of AR. Hypersensitivity, obstruction and/or inflammation in the lower airway can be detected in patients with AR without awareness or diagnosis of asthma, and AR is known as a risk factor for the new onset of wheeze and asthma both in children and adults. Allergen immunotherapy, pharmacotherapy and surgery for AR can contribute to asthma control; however, a clear preventive effect on the new onset of asthma has been demonstrated only for immunotherapy. Pathological similarities such as epithelial shedding are also seen between asthma and CRS, especially eosinophilic CRS. Abnormal sinus findings on computed tomography are seen in the majority of asthmatic patients, and asthmatic patients with CRS show a significant impairment in Quality of Life (QOL) and pulmonary function as compared to those without CRS. Conversely, lower airway inflammation and dysfunction are seen in non-asthmatic patients with CRS. Treatments for CRS that include pharmacotherapy such as anti-leukotrienes, surgery, and aspirin desensitization show a beneficial effect on concomitant asthma. Acting as a gatekeeper of the united airways, the control of inflammation in the nose is crucial for improvement of the QOL of patients with co-existing AR/CRS and asthma.

show abstract

Section: Presence and Characterization Of Comorbidity Of Chronic Rhinsupporting

confidence: 52%

Association and management of eosinophilic inflammation in upper and lower airways

Okano

Kariya

Ohta

et al. 2015

Allergology International

View full text Add to dashboard Cite

show abstract

“…It may be explained by only anatomical changes in septal deviation to anatomical as well as physiological changes in the respiratory mucosa occurring in chronic rhinosinusitis. In a study by Kariya et al 6 pulmonary function was measured in 68 (23.2%) patients with chronic rhinosinusitis without nasal polyps, 89 (30.4%) patients with allergic rhinitis, 135 (46.2%) patients with chronic rhinosinusitis with nasal polyps and 100 normal controls. They found that pulmonary function of patients with chronic rhinosinusitis was significantly affected thus indicating latent obstructive lung function changes in chronic rhinosinusitis patients which supported our findings.…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Nasal Obstruction on Pulmonary Function

Saxena¹,

Srivastava²,

Chander³

et al. 2020

IJCMR

View full text Add to dashboard Cite

Introduction: Upper and lower respiratory diseases are closely related which has been well documented in literature. Even though a relationship between upper and lower airway disease has been described, altered pulmonary function in patients with upper airway diseases is still not fully understood. The present study was conducted to assess the effect of chronic nasal obstruction on pulmonary function and to compare the pulmonary function in same patients after surgical relief of nasal obstruction.

show abstract

“…Long-term inflammatory stimulation of the bronchus causes the formation of chronic inflammation and small airway abnormality, then leading to declined pulmonary ventilation and small airway obstruction. Kariya et al [17] found the level of interleukin-5 in nasal secretions was significantly correlated with pulmonary function in patients with CRS. These studies indicate or suggest CRS patients will suffer from impairments of lung function.…”

Section: Discussionmentioning

confidence: 99%

The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

Zhang

et al. 2016

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

Objectives Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied.Methods One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters.Results The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P<0.05). On peak expiratory flow, there was no difference between three groups. In CRSwNP group, FEV1 was negatively correlated with peripheral blood eosinophil count (PBEC) and duration of disease (r=–0.348, P=0.013 and r=–0.344, P=0.014, respectively), FEF25-75 negatively with VAS, SNOT-20 (r=–0.490, P=0.028 and r=–0.478, P=0.033, respectively) in CRSsNP group. The incidence of positive bronchial provocation and dilation test was lower in CRSwNP group (10% and 0%, respectively), with both 0% in CRSsNP group. The multiple linear regression analysis indicated that change ratio of FEV1 before and after bronchial provocation or dilation test were correlated with PBEC in CRSwNP group (β=0.403, P=0.006).Conclusion CRS leading to impaired maximum ventilation and small airway is associated with the existence of nasal polyp. Lung function impairments can be reflected by PBEC, duration, VAS, and SNOT-20. In CRSwNP patients, PBEC is independent predictor of FEV1 change ratio.

show abstract

Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis

Abstract: The findings indicated latent obstructive lung function changes in chronic rhinosinusitis patients. The cytokines in nasal secretions might be related to obstructive lung function changes in chronic rhinosinusitis.

Cited by 22 publications

References 34 publications

Association and management of eosinophilic inflammation in upper and lower airways

Association and management of eosinophilic inflammation in upper and lower airways

Effect of Chronic Nasal Obstruction on Pulmonary Function

The Lung Function Impairment in Non-Atopic Patients With Chronic Rhinosinusitis and Its Correlation Analysis

Contact Info

Product

Resources

About