Pulmonary function tests in patients with Parkinson's disease: A case-control study

Owolabi, LF; Nagoda, M; Babashani, Musa

doi:10.4103/1119-3077.173714

Cited by 29 publications

(29 citation statements)

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“…Parkinson's disease patients can experience an impairment in the tone, contractility and coordination of the thoracic musculature, affecting both respiratory mechanics and pulmonary functions (Baille et al., ; Owolabi et al., ; Reyes, Ziman, & Nosaka, ). Therefore, studies that evaluate the respiratory mechanics in a model of PD might lead to greater understanding of the effects of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have also found that PD patients showed a reduction of pulmonary volumes and stiffening of respiratory muscles, indicating an impairment directly in the lung, ribcage and/or the muscles responsible for breathing (Baille et al., ; LeWitt et al., ; Owolabi et al., ; Seccombe et al., ). Additionally, clinical reports describe a predisposition to development of lung infections by PD patients, and to embolism and allergic reactions, compared with the general population (Hampson, Kieburtz, LeWitt, Leinonen, & Freed, ; Letsiou et al., ; Owolabi et al., ). Furthermore, areas in the brain responsible for the operation of swallowing and coughing movements can be downregulated in PD; therefore, lung infections in those patients could be associated with dysphagia (Hinkel et al., ; Schiffer & Kendall, ; van Hooren et al., ).…”

Section: Introductionmentioning

confidence: 93%

Section: Impairment Of Lung Properties In Pd Micementioning

confidence: 99%

“…Breathing problems are recognized as a cause of morbidity and mortality in patients with Parkinson's disease (PD), caused by neural damage in specific regions of the ventral medulla that are responsible for rhythm generation and chemoreception, such as the preBötzinger complex (preBötC) and retrotrapezoid nucleus (RTN), respectively (Baille et al., ; Benarroch, Schmeichel, Low, & Parisi, ; Owolabi, Nagoda, & Babashani, ; Seccombe et al., ; Torsney & Forsyth, ). Previous studies have also found that PD patients showed a reduction of pulmonary volumes and stiffening of respiratory muscles, indicating an impairment directly in the lung, ribcage and/or the muscles responsible for breathing (Baille et al., ; LeWitt et al., ; Owolabi et al., ; Seccombe et al., ). Additionally, clinical reports describe a predisposition to development of lung infections by PD patients, and to embolism and allergic reactions, compared with the general population (Hampson, Kieburtz, LeWitt, Leinonen, & Freed, ; Letsiou et al., ; Owolabi et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Respiratory disturbances in a mouse model of Parkinson's disease

Oliveira

Moriya

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and its importance?A mouse model of PD has reduced neurokinin‐1 receptor immunoreactivity in the pre‐Bӧtzinger complex and Phox2b‐expressing neurons in the retrotrapezoid nucleus. The PD mouse has impairments of respiratory frequency and the hypercapnic ventilatory response. Lung collagen deposition and ribcage stiffness appear in PD mice. Abstract Parkinson's disease (PD) is a neurodegenerative motor disorder characterized by dopaminergic deficits in the brain. Parkinson's disease patients may experience shortness of breath, dyspnoea, breathing difficulties and pneumonia, which can be linked as a cause of morbidity and mortality of those patients. The aim of the present study was to clarify whether a mouse model of PD could develop central brainstem and lung respiratory abnormalities. Adult male C57BL/6 mice received bilateral injections of 6‐hydroxydopamine (10 μg μl−1; 0.5 μl) or vehicle into the striatum. Ventilatory parameters were assessed in the 40 days after induction of PD, by whole‐body plethysmography. In addition, measurements of respiratory input impedance (closed and opened thorax) were performed. 6‐Hydroxydopamine reduced the number of tyrosine hydroxylase neurons in the substantia nigra pars compacta, the density of neurokinin‐1 receptor immunoreactivity in the pre‐Bӧtzinger complex and the number of Phox2b neurons in the retrotrapezoid nucleus. Physiological experiments revealed a reduction in resting respiratory frequency in PD animals, owing to an increase in expiratory time and a blunted hypercapnic ventilatory response. Measurements of respiratory input impedance showed that only PD animals with the thorax preserved had increased viscance, indicating that the ribcage could be stiff in this animal model of PD. Consistent with stiffened ribcage mechanics, abnormal collagen deposits in alveolar septa and airways were observed in PD animals. Our data showed that our mouse model of PD presented with neurodegeneration in respiratory brainstem centres and disruption of lung mechanical properties, suggesting that both central and peripheral deficiencies contribute to PD‐related respiratory pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Impairment Of Lung Properties In Pd Micementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Respiratory disturbances in a mouse model of Parkinson's disease

Oliveira

Moriya

et al. 2019

Experimental Physiology

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“…Although there have been numerous studies of pulmonary function in PD, few have investigated the contributions of central and peripheral respiratory mechanisms using functional respiratory testing in patients with dyspnea. Table summarizes the key studies addressing pulmonary dysfunction in PD and shows the frequency of restrictive and obstructive patterns . Review of these studies shows a lack of consistent findings, which is likely due to the fact that they included diverse cohorts of patients at different stages of disease and used variable outcome measures.…”

Section: Studies Of Pulmonary Function In Pdmentioning

confidence: 99%

Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

et al. 2020

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Dyspnea is an under‐recognized and debilitating symptom that is reported in up to 40% of patients with Parkinson's disease and may have multiple origins. Despite its frequency, it is poorly researched, and there is a general lack of understanding of the pathophysiology of dyspnea and respiratory dysfunction in PD. Consequently, a number of PD patients are labelled as having “unexplained dyspnea.” Studies to date have focused mainly on evaluating ventilatory capacity and lung volumes, and little is known about the effects of the disease on the medullary and pontine ventilatory control centers within the brainstem. This is of particular relevance in view of neuropathological studies demonstrating early involvement of the dorsal medulla and other brainstem structures by the disease process. The possibility that impaired brainstem ventilatory control is a contributory mechanism for dyspnea and could be a premotor manifestation in some PD patients therefore warrants further attention. This review focuses on clinical, pathological, and experimental evidence for the involvement of brainstem respiratory centers in PD. We highlight the need for further research, particularly in PD patients with unexplained dyspnea. © 2020 International Parkinson and Movement Disorder Society

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Changes in Respiratory Mechanics Associated with Different Degrees of Parkinson’s Disease

Caldas

Ribeiro

Pereira

et al. 2022

XXVII Brazilian Congress on Biomedical Engineering

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Pulmonary function tests in patients with Parkinson's disease: A case-control study

Abstract: In this study, the values of the evaluated PFTs (VC, FEV1, FEV1/VC, and PEFR) parameters were significantly lower in PD compared with age- and sex-matched control.

Cited by 29 publications

References 0 publications

Respiratory disturbances in a mouse model of Parkinson's disease

Respiratory disturbances in a mouse model of Parkinson's disease

Brainstem Ventilatory Dysfunction: A Plausible Mechanism for Dyspnea in Parkinson's Disease?

Changes in Respiratory Mechanics Associated with Different Degrees of Parkinson’s Disease

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