Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Gao, Jian; Rizzo, Stefania; Li, Hong; Qiu, Xiang; Warth, Arne; Seki, Nobuhiko; Hasegawa, Mizue; Zou, Jia Wei; Li, Qian; Femia, Marco; Lv, T.; Song, Yong

doi:10.21037/tlcr.2017.01.02

Cited by 77 publications

(72 citation statements)

References 59 publications

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“…Previous studies have found that GGOs do not necessarily indicate malignancy. [5][6][7] Benign conditions, including focal interstitial fibrosis, 5 infection, inflammatory processes or pulmonary hemorrhage, 8 can present as GGOs on CT. Our present study provided pathological patterns of resected benign solitary GGOs. Focal fibrosis was identified in 17 cases (48.5%) and infection/inflammation in seven cases (20.0%).…”

Section: Discussionmentioning

confidence: 99%

“…The main components of focal fibrosis are interstitial septal thickening with fibroblast proliferation and preservation of the intra-alveolar airspace, and the solid components may be related to the presence of fibrotic foci or alveolar collapse. 7 Some of the pathologic changes are irreversible, which may explain why GGOs do not disappear during follow-up. Inflammation can be related to any kind of infectious pneumonia, but cytomegalovirus (CMV) and Pneumocystis jirovecii are the most frequently reported.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of resected solitary ground‐glass opacities: Comparison between benign and malignant nodules

Qin

et al. 2020

Thoracic Cancer

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Background: The management of ground-glass opacities (GGOs) depends mainly on personal experience. In clinical practice, benign GGOs are not rare in resected specimens, for which operations may be avoided. We retrospectively compared the clinical features of resected GGOs to identify differential diagnostic characteristics. Methods: Among 1456 patients with suspected malignant GGOs who underwent surgical resection, 105 patients (35 with benign GGOs and 70 matched controls with malignant GGOs) were included. Clinical characteristics, including demographics and radiologic, surgical and pathologic characteristics, were collected. Results: The smoking index (P = 0.044), frequency of coughing (P = 0.026), GGO size (P = 0.003), size change during follow-up (P = 0.011), location (P = 0.022), presence of air bronchogram sign (P = 0.004), distance to the pleura (P = 0.021) and positron emission tomography/computed tomography (PET/CT) appearance (P = 0.003) showed significant differences between the benign and malignant groups. Pathologically, the resected benign GGOs included focal fibrosis (17), inflammation or infection (seven), lymphoproliferative disorder (one), hamartoma (three), inflammatory myofibroblastic tumor (two), hemangioma or vascular malformation (two), endometriosis (two) and pulmonary cyst (one). Conclusions: A higher smoking index, coughing, larger size, similar or increased size during follow-up, location in the upper and middle lobes, air bronchogram sign on CT, lesion margin to pleura distance over 1 cm, and malignant tendency on PET/CT reports were associated with malignant GGOs. Relatively active surgical interventions could be considered for GGOs highly suspected of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of resected solitary ground‐glass opacities: Comparison between benign and malignant nodules

Qin

et al. 2020

Thoracic Cancer

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“…A number of studies have reported the use of HRCT (22)(23)(24)(25)(26) or radiomics (27)(28)(29) in predicting early lung adenocarcinoma invasiveness. Methods such as HRCT and radiomics are limited by the significant pretreatment required to extract imaging biomarkers, reducing the reproducibility.…”

Section: Discussionmentioning

confidence: 99%

3D convolutional neural network for differentiating pre-invasive lesions from invasive adenocarcinomas appearing as ground-glass nodules with diameters ≤3 cm using HRCT

Wang¹,

Wang²,

Zhang³

et al. 2018

Quant. Imaging Med. Surg.

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“…The location of these opacities can be helpful: in the case of ILD, it is typically bilateral, peripheral, posterior, and lower lobe in distribution, whereas in heart failure, the distribution is typically centrilobular (40). Infection typically causes patchy, irregularly distributed areas of ground-glass opacification.…”

Section: Evaluation For Possible Interstitial Lung Disease In Sscmentioning

confidence: 99%

Expert Perspectives On Clinical Challenges: Expert Perspectives: Challenges in Scleroderma

Simms

2020

Arthritis & Rheumatology

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You are consulted to evaluate a 56‐year‐old woman with known Raynaud's phenomenon, finger swelling of several; months’ duration, and new hypertension with a blood pressure of 160/100 mm/Hg. She also reports progressive shortness of breath. Physical examination reveals telangiectasias, sclerodactyly, and proximal skin sclerosis (thick shiny skin on the chest and upper arms), and bibasilar crackles are found on chest examination. Laboratory tests reveal evidence of microangiopathic hemolytic anemia, thrombocytopenia, and elevation of the serum creatinine level (previously normal), and chest computed tomography shows evidence of ground‐glass opacification in both lower lung fields.

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Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Cited by 77 publications

References 59 publications

Clinical characteristics of resected solitary ground‐glass opacities: Comparison between benign and malignant nodules

Clinical characteristics of resected solitary ground‐glass opacities: Comparison between benign and malignant nodules

3D convolutional neural network for differentiating pre-invasive lesions from invasive adenocarcinomas appearing as ground-glass nodules with diameters ≤3 cm using HRCT

Expert Perspectives On Clinical Challenges: Expert Perspectives: Challenges in Scleroderma

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