Pulmonary Haemosiderosis (apparently Idiopathic) associated with Myocarditis, with Bilateral Penetrating Corneal Ulceration, and with Diabetes Mellitus

Murphy, K.

doi:10.1136/thx.20.4.341

Cited by 7 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between the heart and lung changes is uncertain. That the combination is fortuitous is unlikely, since the association of idiopathic pulmonary haemosiderosis with a myocarditis or myocardial abnormality other than cor pulmonale has been reported in at least nine other subjects in the past (Gellerstedt, 1939;Glanzmann and Walthard, 1941 ;Scheidegger and Dreyfus, 1945;Wigod, 1955;Soergel, 1957;Campbell and Macafee, 1959;Saltzman, West, and Chomet, 1962;Murphy, 1965). Nor is it likely that the pulmonary changes are secondary to cardiac damage, as pulmonary haemosiderosis similar to that found with severe mitral stenosis or prolonged left ventricular failure has not, so far as the authors are aware, been reported with other cardiac abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic pulmonary haemosiderosis with myocarditis. Radio-isotope studies in a patient treated with prednisone.

Kennedy¹,

Shearman²,

Delamore³

et al. 1966

Thorax

View full text Add to dashboard Cite

This disease of children and young adults is characterized by recurrent intrapulmonary haemorrhage with deposition of haemosiderin in the lungs and the development of interstitial pulmonary fibrosis. Detailed reviews of the condition have been published by such authors as Rudnick and Takamura (1961), Soergel and Sommers (1962), and Ognibene and Johnson (1963).A further case is here reported of a young adult in whom detailed studies of iron absorption and turnover were undertaken. METHODSIn the fasting state an oral dose of 10 /_c. "9Fe was given in 25 mg. of ferrous sulphate accompanied by 42 5 mg. of ascorbic acid.Iron utilization by the red cells was measured by counting the radioactivity in samples of 5 ml. of haemolysed whole blood. Measurements were made in a well-type sodium iodide scintillation counter.Absorption of radioactive iron was determined by means of a simple whole-body counter. At first a 7 5 cm. diameter x 7-5 cm. thick sodium iodide crystal was used, but this was later replaced by a 12 5 cm. diameter x 7-5 cm. thick crystal. Counts were made over the subject both prone and supine with the counter in three reproducible positions, the distance from crystal to bed being 49 cm. This procedure was found to be relatively independent of radioactive redistribution within the body. Whole-body counting was carried out in a normal unshielded room, and to obtain some reduction in background there was a 2 5 cm. thick lead shield at the sides of and above the crystal.Allowance was made for radioactive decay and electronic drift by counting a standard quantity of 59Fe in a reproducible position at the time of each whole-body measurement.

show abstract