Pulmonary hypertension and pregnancy

Madden, Brendan

doi:10.1016/j.ijoa.2008.10.006

Cited by 95 publications

(92 citation statements)

References 49 publications

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“…There is an increase in right-to-left shunting which aggravates pulmonary vasoconstriction and right heart failure. 14,15 Among parturients with pulmonary artery hypertension, majority of deaths occur in peri-partum period.2 This is due to the haemodynamic changes which occur in pregnancy and are further exaggerated by the acute changes during labour and delivery. The haemodynamic stress of labour causes hypercarbia and acidosis which leads to acute rise in pulmonary pressures leading to right heart failure.…”

Section: Discussionmentioning

confidence: 99%

Successful maternal outcome after vaginal delivery in a patient with Eisenmenger Syndrome

Chauhan

Agarwal

Gupta

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Patients with Eisenmenger syndrome are advised against pregnancy. Sometimes patients are diagnosed with Eisenmenger syndrome for the first time during pregnancy. This is what has happened in our case. A primigravida was diagnosed with ventricular septal defect with severe pulmonary artery hypertension for the first time during pregnancy at 34 weeks period of gestation. Management of such patients is challenging with different studies showing variable results. Here we describe such a case which was managed conservatively and was allowed to go into labour spontaneously with vacuum extraction during second stage which subsequently led to a favourable maternal outcome.

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Section: Discussionmentioning

confidence: 99%

Successful maternal outcome after vaginal delivery in a patient with Eisenmenger Syndrome

Chauhan

Agarwal

Gupta

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…In case of pulmonary hypertension, successful use of epoprostenol and sildenafil has been reported in patients with PAH during pregnancy. Anticoagulation with lowmolecular-weigth heparin is recommended to reduce risk of thromboembolism, since antivitamine K agents are teratogenic [41]. Calcium channel blockers are classically contra-indicated during pregnancy.…”

Section: Medications During Pregnancymentioning

confidence: 99%

Pregnancy and Scleroderma

Gorgiard¹,

Bérezné²,

Mouthon³

2012

Systemic Sclerosis - An Update on the Aberrant Immune System and Clinical Features

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“…Blood volume expands up to 40% by term (Thornberg 2000) and most of the increase is due to plasma volume increases (Madden 2009). In addition, the red cell mass enlarges by 30% (Thornberg 2000).…”

Section: Pulmonary Vasculaturementioning

confidence: 99%

“…PVR returned to normal by 6 months post partum. (Robson 1991) CO may increase by 25-30% during the second stage of labor due to uterine contractions and by up to 80% immediately post partum due to autotransfusion of blood from the uterus to the systemic circulation (Madden 2009). Postpartum, heart rate, systemic vascular resistance, and cardiac output decrease and cardiac enlargement begins to regress.…”

Section: Pulmonary Vasculaturementioning

confidence: 99%