Pulmonary hypertension as a risk factor of mortality after lung transplantation

Andersen, Kasper; Schultz, Hans Henrik Lawaetz; Nyholm, Benjamin; Iversen, Martin; Gustafsson, Finn; Carlsen, Jørn

doi:10.1111/ctr.12692

Cited by 25 publications

(21 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of PH in this context has not been completely revealed. 1,[9][10][11][12] In our study, moderate to severe PH was diagnosed by RHC in one-fifth of the study population. These data confirm that PH is a highly prevalent condition in patients with end-stage pulmonary disease.…”

Section: After the Establishment Of A Pgd Consensus Definition Inmentioning

confidence: 50%

“…Andersen et al demonstrated that pre‐ and post‐capillary PH are risk factors for increased 90‐day mortality after LTX. Interestingly, the analysis did not detect any difference, in terms of long‐term survival post‐transplantation, in these patients compared to patients without PH …”

Section: Discussionmentioning

confidence: 73%

“…After the establishment of a PGD consensus definition in 2005 and its validation thereafter, the characteristics of donors and recipients as well as the perioperative risk factors have been investigated for a potential role in the development of PGD3. The role of PH in this context has not been completely revealed …”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the analysis did not detect any difference, in terms of long-term survival post-transplantation, in these patients compared to patients without PH. 12 The definition of PH in the context of lung disease has been clarified over the last few years, and therefore, directly comparing different studies of the role of PH in these patients remains difficult.…”

Section: After the Establishment Of A Pgd Consensus Definition Inmentioning

confidence: 99%

“…The impact of PH on survival after LTX has previously been investigated for the most common lung pathologies, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and idiopathic pulmonary fibrosis (IPF), but with conflicting results. [9][10][11][12] In this study, we investigated the role of PH as risk factor for the development of PGD3 after LTX.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Pulmonary hypertension is not a risk factor for grade 3 primary graft dysfunction after lung transplantation

Cottini

Brandi

Pagnamenta

et al. 2018

Clinical Transplantation

View full text Add to dashboard Cite

Grade 3 primary graft dysfunction (PGD3) represents the most important risk factor for patient mortality during the first year after lung transplantation (LTX). We investigated whether pretransplant pulmonary hypertension (PH) is a risk factor for the development of PGD3. This retrospective, single-center cohort study included 96 candidates undergoing right heart catheterization (RHC) prior to being listed for LTX between March 2000 and October 2015. Based on their mean pulmonary artery pressure (mPAP) levels, the patients were classified into 3 groups: (1) <25 mm Hg, (2) 25-34 mm Hg and (3) ≥35 mm Hg. Forty-seven patients were classified in group 1, 31 in group 2, and 18 in group 3. Fifteen recipients (16%, 95%-CI 8-23) developed PGD3. In the univariate analysis, the diagnosis of interstitial lung disease (ILD) compared to COPD (OR: 7.06, P = .005), blood transfusion >1000 mL during surgery (OR: 5.25, P = .005), the need for intra-operative cardio-pulmonary bypass (CPB) or extra-corporeal membrane oxygenation (ECMO) (OR: 4, P = .027), mPAP (OR 1.06, P = .007) and serum high density lipoprotein-cholesterol (HDL-C) (OR 0.09, P = .005) were associated with PGD3. In the multivariable logistic regression analysis, only HDL-C (OR 0.10, P = .016) was associated with PGD3 based on our single-center cohort data analysis.

show abstract