Pulmonary Hypertension in Hemodialysis Patients

Moniruzzaman, Mohammad; Islam, MM; Alam, Muhammad; Alam, Abm Mobasher; Khan, M.I.; Ali, Zulfikar; Chowdhury, AW; Chowdhury, M S

doi:10.3329/cardio.v4i2.10459

Cited by 6 publications

(12 citation statements)

References 11 publications

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“…[18] found PH prevalence to be as low as 26.74% and Moniruzzaman et al . [5] found it to be as high as 68.6%. In another Indian study Patel et al .…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of PH in this cohort was 41% and the highest prevalence was in the HD group (33%). The variability in the prevalence of PH among CKD patients in different studies[518192021] can be explained by the difference in the ethnicity of the population studied as well as in the study group, regarding stage of CKD, mode of dialysis (HD vs PD), comorbid conditions such as COPD/CHF and inclusion criteria. Though these studies considered different parameters and are not truly comparable, most concluded that there was high prevalence of PH among CKD patients.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of PH among patients on HD was studied by Moniruzzaman et al . [5] and Kiykim et al . [32] and was found to be 68.6% and 68.8%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Transthoracic Doppler echocardiography for measurement of pulmonary artery systolic pressure (PASP) based on the tricuspid regurgitation jet[5] was performed on all patients. Those on hemodialysis underwent echocardiography 4 hours post dialysis.…”

Section: Methodsmentioning

confidence: 99%

“…PH was defined when mean pulmonary artery pressure exceeded 30 mmHg. [5] PH was further categorized as mild (>30 to <35 mmHg), moderate (35 to 50 mmHg), and severe (>50 mmHg).…”

Section: Methodsmentioning

confidence: 99%

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Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

et al. 2019

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The prevalence of pulmonary hypertension (PH) in chronic kidney disease (CKD) in Indian patients has been evaluated in this study. In addition, association of PH with CKD etiology, its prevalence in various CKD stages, correlation between the severity of PH with CKD duration, various related biochemical parameters, and their relation to PH in CKD patients were analyzed. This cross-sectional and prospective study included 200 CKD patients. Detailed history and clinical examination were recorded. Hemoglobin, blood urea nitrogen (BUN), serum creatinine, albumin, and calcium-phosphorus product were recorded. Pulmonary function test was evaluated and two-dimensional echo was done 4 hours post dialysis. The prevalence of PH in CKD patients was 60.5%, with mean pulmonary artery systolic pressure (PASP) of 38.52 ± 7.32 mmHg. The mean age of those with PH was 47.85 ± 13.09 years. PH was more common in males ( p = 0.03). The prevalence of PH increased as CKD stage advanced ( p < 0.001). Diabetes and hypertension had a strong association with PH ( p < 0.001). The prevalence ( p = 0.003) and severity ( p = 0.011) of PH increased with increase in CKD duration. In patients on hemodialysis (HD), the prevalence ( p < 0.001) and severity ( p = 0.022) of PH was significant compared to those on conservative treatment. The prevalence ( p < 0.001) and severity ( p < 0.001) of PH significantly increased as duration of HD increased. The prevalence of PH was significantly higher in patients with arteriovenous fistula ( p = 0.002). Serum creatinine ( p = 0.02) and serum calcium-phosphorus product ( p < 0.001) were significantly higher in patients with PH. The prevalence of PH in CKD patients was 60.5%. There was a positive correlation between PH and duration of CKD, duration of HD, BUN, serum creatinine, and serum calcium-phosphorus product.

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“…[18] found PH prevalence to be as low as 26.74% and Moniruzzaman et al . [5] found it to be as high as 68.6%. In another Indian study Patel et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The prevalence of PH among patients on HD was studied by Moniruzzaman et al . [5] and Kiykim et al . [32] and was found to be 68.6% and 68.8%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…PH was defined when mean pulmonary artery pressure exceeded 30 mmHg. [5] PH was further categorized as mild (>30 to <35 mmHg), moderate (35 to 50 mmHg), and severe (>50 mmHg).…”

Section: Methodsmentioning

confidence: 99%

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Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

et al. 2019

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Prevalence of Pulmonary Hypertension in Patients of Chronic Kidney Disease in Western Rajasthan: A Cross-Sectional Study

VYAS

Yadav

Agrawal

2022

Asian J Pharm Clin Res

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Objective: We organized a study to determine the prevalence of pulmonary hypertension (PHT) in individuals with chronic renal disease, because there has not been much research on this topic in our area. Studying any relationships, if any, between PHT and chronic kidney disease (CKD) stage was another goal. Methods: A hospital-based cross-sectional study of 108 CKD cases was carried out (according to various phases based on glomerular filtration rate) and included participants over the age of 18. SPSS software was used to collect and analyze all data. Correlation was determined using the corelation coefficient. Results: About 15.74% of people with CKD had PHT. Patients’ PHT was mild in 47.06% of cases, moderate in 41.18% of cases, and severe in 11.11% of cases. The correlation between the stage of CKD and PHT was determined to be statistically negligible. Age, CKD stage and duration, and PAH were revealed to be statistically unimportant in linear regression. Conclusion: About 15.74% of CKD patients had PHT, according to the study. The age of the patients, the length of the CKD, and the stage of the CKD were positively correlated with PHT.

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Evaluation of Risk Factors for Development of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

Hussein Fadhil ,,

Mahdi Hashim ,,

Sami Malik ,

et al. 2023

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Background: Pulmonary arterial hypertension (PAH) has recently been identified as a common complication in patients with end-stage renal disease (ESRD) who are undergoing hemodialysis (HD) or peritoneal dialysis (PD). The risk factors for the development of PAH in those patients are not well understood. Objective: To investigate the risk factors for the development of PAH in patients with ESRD on HD. Patients and Methods: This is a hospital-based cross-sectional study of 50 ESRD patients undergoing HD. The pulmonary artery systolic pressure (PASP) was measured using echocardiography. PASP ˃ 25 mmHg at rest was defined as PAH. As a result, patients were divided into two groups: those who had PAH and those who did not. Each patient's demographic, biochemical, and echographic findings were documented. Results: Out of 50 patients, 19 (38%) had PAH, while the remaining 31 (62%) had normal PASP. In multivariate analysis, HD duration > 3.4 years (OR= 2.13, 95%CI=1.45-31.38, p= 0.025), hypertension as a cause of ESRD (OR=6.12, 95%CI=1.4-26.77, p=0.031), hemoglobin (Hb) ≤ 10.0 g/dl (OR= 4.35, 95%CI=1.88-9.84, p= 0.018), and left ventricular ejection fraction (LVEF)≤ 55% (OR= 6.75, 95%CI=1.87-23.74, p=0.021) were independent factors associated with PAH. PASP had a significant positive correlation with the rate of fistula flow (r= 0.295, p= 0.038) and E/A ratio (r= 0.368, p= 0.008), but a significant negative correlation with LVEF (r= -0.345, p= 0.014). PASP had a positive significant correlation with each of rate of fistula flow (r= 0.295, p= 0.038) and E/A ratio (r= 0.368, p= 0.008), while it has a negative significant correlation with LVEF (r= -0.345, p= 0.014). Conclusion: Longer duration of HD, hypertensive nephropathy as a cause of ESRD, Hb≤ 10 g/dl, and LVEF ≤55% are among the demographic, biochemical, and clinical factors associated with the development of PAH in patients with ESRD under HD. The PASP has a positive correlation with fistula flow rate and E/A ratio and a negative correlation with LVEF.

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Pulmonary Hypertension in Hemodialysis Patients

Abstract: Abstract:Background: Pulmonary hypertension (PH) has been reported to be high among maintenance dialysis patients. There is a paucity of data on the incidence and prevalence of pulmonary hypertension in chronic kidney disease (CKD)

Cited by 6 publications

References 11 publications

Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

Pulmonary hypertension in various stages of chronic kidney disease in Indian patients

Prevalence of Pulmonary Hypertension in Patients of Chronic Kidney Disease in Western Rajasthan: A Cross-Sectional Study

Evaluation of Risk Factors for Development of Pulmonary Hypertension in Patients with End Stage Renal Disease Undergoing Hemodialysis

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