Pulmonary hypertension in hemolytic anemias

Wahl, S.; Vichinsky, Elliott

doi:10.3410/m2-10

Cited by 18 publications

(16 citation statements)

References 47 publications

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“…But, whether hemolysis is a cause or effect of hypertension remains unclear. Most studies suggest that hypertension is a complication of hemolysis and associated with hemolytic anemia [ 35 ]. In addition to this, blood disorders such as polycythemia vera and essential thrombocythemia, causes hypertension [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

et al. 2017

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BackgroundHypertension is a major health problem worldwide. It can lead to cardiovascular disease and also leads to functional disturbances including hematological parameters. The abnormalities of haematological parameters may enhance an end-organ damage. Therefore, the aim of this study was to assess some hematological parameters of hypertensive individuals in comparison with normotensive individuals at University of Gondar hospital, northwest Ethiopia.MethodsA cross sectional comparative study was conducted from October to November 2015 on a total of 126 hypertensive and 126 normotensive individuals at University of Gondar Hospital. All participants after taking informed consent were interviewed for detailed history and 3 ml of blood was collected for hematological test analysis. Independent t-test and the Mann Whitney u-test were used to find out significant difference and Pearson’s and Spearman’s correlation were used for correlation test. P values less than 0.05 was considered the level of significance.ResultFrom a total of 252 study subjects, about 67.5% were females. The mean age of study subjects was 50.3 ± 11 years for hypertensive individuals and 49.8 ± 11.6 years for normotensive individuals with range of 18–65 years. In the present study, the median (IQR) value of WBC, RBC, Hgb, HCT, MCV and the mean value of MCHC, RDW, MPV and PDW were significantly higher in hypertensive group compared to apparently healthy normotensive groups. Additionally, WBC, RBC, Hgb, HCT and PLT showed statistically significant positive correlations with blood pressure indices. Platelet count and MCH did not show statistically significant difference between the two groups.ConclusionHypertension has impact on hematological parameters. In this study, the mean and median values of haematological parameters in hypertensive individuals were significantly different compared to apparently healthy normotensive individuals. Hence, hematological parameters can be used to monitor the prognosis of the disease and manage hypertensive related complications, and it is important to assess hematological parameters for hypertensive individuals which may help to prevent complications associated hematological disorders.Electronic supplementary materialThe online version of this article (doi: 10.1186/s12878-017-0093-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

et al. 2017

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“…Anaemia is associated with higher cardiovascular risk, higher blood pressure values, and lower dipping status in hypertensive patients, and haemoglobin should be monitored in hypertensive patients [33]. During HTN, there is a possibility of haemolysis [34] [35] [36] [37]. Previous studies suggest that hypertension is a complication of hemolysis and associated with haemolytic anaemia [38].…”

Section: Discussionmentioning

confidence: 99%

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Erhabor¹,

Shehu²,

Erhabor³

et al. 2019

OJBD

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Hypertension (HTN) is a major health problem worldwide. It can lead to cardiovascular disease and functional disturbances including haematological parameters. Full blood count (FBC) parameters of a total of 60 consecutively-recruited hypertensive subjects and 30 age-matched non-hypertensive controls were studied between June and September, 2018. Ethylene Diamine Tetra Acetic Acid (EDTA) anticoagulated blood and serum from subjects and control participants were analyzed for FBC. The total white cell count (WBC), packed cell volume (PCV) haemoglobin (Hb), neutrophils and eosinophils were significantly lower among hypertensive subjects compared to non-hypertensive controls (p < 0.01, p = 0.02, p < 0.01, p < 0.01, p < 0.01) respectively. The red cell count, monocyte and lymphocyte count were significantly higher among the hypertensive subjects compared to controls (p = 0.00). There was a statistically significant variation in the haemoglobin, platelet count and red cell distribution width among the hypertensive subjects based on the stage of the hypertensive disease (p < 0.01, p = 0.01 and p < 0.01) respectively. The haematological parameters were compared among the hypertensive subjects based on age, gender and ethnicity. The PCV and platelet count were significantly higher among hypertensives >40-year-old compared to those <40 years of age (p = 0.02 and 0.01) respectively. The RBC count was significantly higher among female compared to male hypertensives (p = 0.05). The haemoglobin and monocyte count were significantly higher among male compared to female hypertensives (p = 0.02 and 0.04) respectively. The monocyte count was significantly higher among hypertensive subjects of Hausa ethnic group compared to Fulani (t = 2.79, p < 0.

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“…Given that pulmonary hypertension is a major complication in many haemolytic conditions, administration of inhaled NO in acute haemolytic conditions may be beneficial. However, NO-based therapies may be limited in their efficacy, as exemplified by recent early termination of a large multicentre trial where sickle cell patients with pulmonary hypertension receiving PDE5 inhibitor had more severe pain crises leading to an increase in hospitalisations 8 9. It has not been demonstrated whether there is benefit to the use of inhaled NO for patients with pulmonary artery hypertension in the setting of AIHA.…”

Section: Discussionmentioning

confidence: 99%

Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism

Woodson¹,

Lee

Gopalratnam

et al. 2016

BMJ Case Reports

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SUMMARYAutoimmune haemolytic anaemia (AIHA) is a disease characterised by the production of pathological antibodies that attach to the surface of a patient's own red blood cells, resulting in haemolysis. It can present in either an acute or a chronic manner. In addition to the obvious consequence of anaemia, there are other potentially deadly complications that can arise from AIHA, such as venous thromboembolism (VTE) and pulmonary hypertension. We report a case of a 52-yearold woman who developed a pulmonary embolism (PE) soon after being diagnosed with AIHA. Despite having a very small pulmonary venous clot burden, she developed profound haemodynamic compromise with severe right ventricular dysfunction, which quickly reversed with inhaled nitric oxide treatment. This case makes an interesting observation of cell-free haemoglobinassociated nitric oxide scavenging as a mechanism of pulmonary hypertension and highlights the possible benefit of nitric oxide in treatment. BACKGROUND

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Pulmonary hypertension in hemolytic anemias

Cited by 18 publications

References 47 publications

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

A comparative cross-sectional study of some hematological parameters of hypertensive and normotensive individuals at the university of Gondar hospital, Northwest Ethiopia

Some Full Blood Count Parameters among Hypertensive Patients Attending Specialist Hospital, Sokoto, Nigeria

Adding insult to injury: autoimmune haemolytic anaemia complicated by pulmonary embolism

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