Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis

Yu, Shiwen; Fan, Yali; Ma, Ruimin; Wang, Yuanying; Ye, Qiao

doi:10.1136/oemed-2021-108095

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Previous reports have revealed that comorbidity with CTD may cause an even worse prognosis for patients with pneumoconiosis because of the increased incidence of pulmonary hypertension. 18 Therefore, the identification of risk factors for CTD secondary to pneumoconiosis may help to identify high-risk patients who can benefit from early therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study

Wang

et al. 2023

BMJ Open

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ObjectiveTo describe the prevalence, clinical features and potential risk factors of pneumoconiosis in combination with connective tissue disease (CTD) or positive autoantibodies.DesignCross-sectional study.SettingA retrospective study of adults recruited in China between December 2016 and November 2021.ParticipantsA total of 931 patients with pneumoconiosis at Beijing Chao-Yang Hospital were enrolled in this study; of these, 580 patients were included in the final analysis.Main outcome measuresPneumoconiosis combined with CTD or positive autoantibodies was a major adverse outcome.ResultsIn total, 13.8% (80/580) of the patients had combined pneumoconiosis with CTD, among whom the prevalence of CTD was 18.3% (46/251) in asbestosis and 11.4% (34/298) in silicosis/coal mine workers’ pneumoconiosis. In comparison to the general Chinese adult population, the relative risk of various CTD in pneumoconiosis, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary Sjögren’s syndrome, idiopathic inflammatory myopathy and antineutrophil cytoplasmic antibodies-associated vasculitis, were 11.85, 12.12, 127.40, 4.23, 9.94 and 644.66, respectively. Multivariate analysis revealed that female sex (OR 2.55, 95% CI 1.56 to 4.17) and a later stage of pneumoconiosis (OR 2.04, 95% CI 1.24 to 3.34) were the independent risk factors for CTD in patients with pneumoconiosis (all p<0.050).ConclusionCTD is highly prevalent in patients with pneumoconiosis, especially in patients of asbestosis, and silicosis/coal mine workers’ pneumoconiosis. Female sex and later stages of pneumoconiosis are associated with an increased risk of combined with CTD.

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Section: Introductionmentioning

confidence: 99%

Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study

Wang

et al. 2023

BMJ Open

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“…In this issue of Occupational and Environmental Medicine, Yu et al 1 present findings from a study of 199 miners with progressive massive fibrosis (PMF). Patients at high or intermediate probability of having pulmonary hypertension (PH, n=79) were defined, for the purposes of this study, as having PH on echocardiogram in combination with secondary signs of PH 2…”

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confidence: 99%

Vascular compression and pulmonary hypertension: the occupational context

Fishwick

Kiely

2022

Occup Environ Med

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Pulmonary Hypertension Associated with Chronic Lung Disease

Wang,

Estrada,

Goel

et al. 2024

CRMR

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Patients with Chronic Lung Disease (CLD) are frequently burdened by pulmonary hypertension (PH), which is associated with reduced functional capacity, poor quality of life, increased oxygen requirements, and increased morbidity and mortality. The development of PH associated with chronic lung disease (PH-CLD) is complex and multifactorial and varies between different types of CLD. In this review, we provide an update on PH-CLD, with a particular focus on Interstitial Lung Disease (ILD), chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and obesity hypoventilation syndrome (OHS). We discussed epidemiology, histopathology, pathophysiology, diagnostic evaluation, and treatment approaches. There are limited data on the use of pulmonary arterial hypertension-specific treatments in PH-CLD, so it has been proposed to phenotype patients based on their degree of pulmonary vascular disease to guide individualized care. The heterogeneity within PH-CLD highlights the importance of identifying novel molecular pathways unique to each subgroup to ultimately achieve precision medicine.

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Pulmonary hypertension in patients with pneumoconiosis with progressive massive fibrosis

Cited by 3 publications

References 33 publications

Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study

Pneumoconiosis combined with connective tissue disease in China: a cross-sectional study

Vascular compression and pulmonary hypertension: the occupational context

Pulmonary Hypertension Associated with Chronic Lung Disease

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