Pulmonary Hypertension in Systemic Lupus Erythematosus complicated by exposure to Dexfenfluramine

Petcu, Eugen Bogdan; Berman, Leonard B.; Opris, Maria M.; Gheorghiu, Valentin; Kessler, Stanton C.; Hayes, J. A.; Farber, Harrison W.

doi:10.4323/rjlm.2009.83

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…They are independent upon the presence of lower limb fractures. This results in in accordance with other similar studies, which reveal cerebral, respiratory and septic consequences as being the most often identified negative prognostic factors in road traffic accidents [11][12][13].…”

Section: Discussionsupporting

confidence: 93%

Sepsis and lower limb fractures in road traffic accidents

Kouris¹,

Hostiuc²,

Negoi³

et al. 2012

RJLM

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Mortality in road traffic accident, even if is slightly decreasing in most countries due to incremental advances in car safety and better prevention programs, is still a significant cause of death. The purpose of this article was to determine whether the lower limb fractures are a determining factor in the development of sepsis and multiorgan failure in road traffic accidents. Material and methods. Retrospective, descriptive study on 82 consecutive cases of clinical expertises and 100 cases of autopsy reports for road traffic accidents. Two parameters, Sev_In and Sev_Tot were build to assess the severity of the septic process. Results. By analyzing the mean value of neutrophil, leucocyte count, and cerebral, cardiac, hepatic, renal and ICD markers for multiorgan failure in the presence of lower limb fractures we could not establish any statistically significant correlations. The evolution os leucocytes leads to a significant inequality of the variance of the Sev_Tot parameter, with both an increase and a decrease in leucoyte count during hospitalization being associated with a significant increased severity compared to a relative unmodified value of this parameter. Conclusion. Lower limb fractures are not a determining factor in neither the development of a septic process as they do not contribute significantly to the mortality in road traffic accidents. Their contribution to severity scores in these circumstances should therefore be limited, and mortality due specifically to lower limb fractures should be regarded as incidental. The development of sepsis in road traffic accidents is independent upon the presence of lower limb fractures, being caused rather by another traumatic lesions produced in the same context.

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Section: Discussionsupporting

confidence: 93%

Sepsis and lower limb fractures in road traffic accidents

Kouris¹,

Hostiuc²,

Negoi³

et al. 2012

RJLM

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“…A search on Scopus identifies only one article when searching the keywords "sepsis," "postmortem," and "Romania," a study which analyses lethal traffic accidents and risk factors (5). The only data regarding sepsis in legal medicine in Romania come from case reports or studies regarding other pathologies in which sepsis was considered to be associated with (6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

Particularities Regarding the Etiology of Sepsis in Forensic Services

Dermengiu

Curcă

Ceauşu

et al. 2013

Journal of Forensic Sciences

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If in clinical practice definitive diagnostic criteria had been established, after death sepsis is often difficult to diagnose, especially if a site of origin is not found or if no clinical data are available. This article will analyze the etiology of sepsis in a medical-legal service with emphasis on the differences in diagnosing it in clinical and forensic environments. A total of 78 cases of sepsis cases diagnosed or confirmed at the autopsy were selected. The etiological agent was determined either during the hospitalization or by postmortem bacteriology. A high prevalence of Gram-negative sepsis was found, especially multidrug-resistant micro-organisms. Most frequent etiological agents were Acinetobacter baumannii, Escherichia coli, Enterobacter, Enterococcus, Pseudomonas, and Klebsiella. Polymicrobial sepsis is much more frequent than in nonforensic cases. In legal medicine, the prevalence of Gram-negative sepsis is much higher than in nonforensic autopsies, and the point of origin is shifted toward the skin and the gastrointestinal system.

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“…alpractice claims associated with infectious disorders are often cited in scientific literature, and are especially caused by the development of nosocomial infections [1][2][3][4][5][6], incorrect diagnosis of major emergencies with septic complications [7][8][9], and neonatal/obstetrical pathology [10]. Medical errors can be grouped into comissive (in agendo), when they are the result of incorrect medical acts, omissive (in omitendo) when they are caused by inaction, technical (in eligendo) when they are the result of incorrect choosing of medical techniques or improper delegation, and correlative (in vigilando) when are the result of incorrect professional relation with another physician(s).…”

mentioning

confidence: 99%

Malpractice claims associated with infectious causes

Vasalos¹,

Salem²,

Hostiuc³

2010

RJLM

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Medical errors leading to malpractice claims have had a continuously increasing frequency in the last years in Romania. In this study we try to analyze the characteristics of malpractice claims associated with infectious pathology. Material and method. A study was conducted on 83 cases with malpractice claims, on a four year period. Thirty cases included in the causal chain an infective process (MOSF as a terminal event was excluded). Results. Cases with associated infectious pathology had a lower mean age, a male predominance, an increased severity and mortality. Its presence however wasn't associated with a significant increase in medical errors frequency. Conclusions. Infectious processes, even if are associated with an increased severity and mortality, don't have a stronger association with the positive identification of medical errors compared with medical treatments not associated with infectious pathology during their course.

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Pulmonary Hypertension in Systemic Lupus Erythematosus complicated by exposure to Dexfenfluramine

Cited by 4 publications

References 13 publications

Sepsis and lower limb fractures in road traffic accidents

Sepsis and lower limb fractures in road traffic accidents

Particularities Regarding the Etiology of Sepsis in Forensic Services

Malpractice claims associated with infectious causes

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