Pulmonary hypoplasia: An analysis of cases over a 20-year period

Delgado-Peña, Yanny Paola; Torrent‐Vernetta, Alba; Sacoto, Gabriela; Mir-Messa, Inés de; Rovira‐Amigo, Sandra; Gartner, Sílvia; Moreno‐Galdó, Antonio; Molino, Jose Andrés; Salinas, Félix Castillo

doi:10.1016/j.anpede.2015.10.022

Cited by 12 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A paternal fish oil diet preconception improved offspring growth independent of postnatal diet; however, this trend did not reach significance (Figure 1A and Table S1). As demonstrated by Figure 1B, a history of paternal TCDD exposure also impaired lung development, denoted by an increased risk of lung hypoplasia, which is associated with poor lung health outcomes [60]. Intervening with a paternal fish oil diet preconception in males with a history of in utero TCDD exposure reduced the offspring's risk of lung hypoplasia, independent of postnatal diet.…”

Section: Discussionmentioning

confidence: 95%

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Rumph

Rayford

Stephens

et al. 2021

Toxics

View full text Add to dashboard Cite

New bronchopulmonary dysplasia is a developmental lung disease associated with placental dysfunction and impaired alveolarization. Risk factors for new BPD include prematurity, delayed postnatal growth, the dysregulation of epithelial-to-mesenchymal transition (EMT), and parental exposure to toxicants. Our group previously reported that a history of paternal toxicant exposure increased the risk of prematurity and low birth weight in offspring. A history of paternal toxicant exposure also increased the offspring’s risk of new BPD and disease severity was increased in offspring who additionally received a supplemental formula diet, which has also been linked to poor lung development. Risk factors associated with new BPD are well-defined, but it is unclear whether the disease can be prevented. Herein, we assessed whether a paternal fish oil diet could attenuate the development of new BPD in the offspring of toxicant exposed mice, with and without neonatal formula feeding. We investigated the impact of a paternal fish oil diet preconception because we previously reported that this intervention reduces the risk of TCDD associated placental dysfunction, prematurity, and low birth weight. We found that a paternal fish oil diet significantly reduced the risk of new BPD in neonatal mice with a history of paternal toxicant exposure regardless of neonatal diet. Furthermore, our evidence suggests that the protective effects of a paternal fish oil diet are mediated in part by the modulation of small molecules involved in EMT.

show abstract

Section: Discussionmentioning

confidence: 95%

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Rumph

Rayford

Stephens

et al. 2021

Toxics

View full text Add to dashboard Cite

show abstract

“…Our study differs from these data, less use of mechanical ventilation could be the reason behind this as mechanical ventilation is known to be a common risk factor for development of pneumothorax. 45,46 Underlying lung pathology was a cause of pneumothorax in neonates rather than being a complication of mechanical ventilation when noted by Esme and coworkers. 47 Vigorous monitoring and maneuvering of ventilation can reduce the risk of pneumothorax, including optimizing PEEP and minimizing PIP.…”

Section: Discussionmentioning

confidence: 97%

Pneumothorax in neonates with meconium aspiration.

Amin¹,

Ahmad²,

Naeem³

et al. 2019

TPMJ

View full text Add to dashboard Cite

Objectives: Recent years have seen advances in respiratory supports for meconium aspiration syndrome (MAS) but pneumothorax (PTX) still stands a significant indicator of disease severity. This study was aimed to determine the frequency of PTX in newborn with meconium aspiration. Study Design: Descriptive, cross-sectional study. Setting: Department of Pediatric Medicine, Unit 1, Bahawal Victoria Hospital, Bahawalpur, and Department of Pediatric Medicine, Ghazi Khan Medical College/Hospital, Dera Ghazi Khan. Period: 1st June 2017 to 30th September 2018. Material and Methods: A total of 736 patients with meconium aspiration of age 1-28 days and both genders were included. Patients with congenital heart anomalies and preterm infants were excluded. Presence or absence of PTX in each patient was noted. Results: Age range in this study was from 1 to 28 days with mean age of 12.80 ± 6.52 days. Majority of the patients 434 (58.97%) were between 1 to 14 days of age. Out of the 736 patients, 394 (53.53%) were male and 342 (46.47%) were females with male to female ratio of 1.2:1. Frequency of PTX in newborn with meconium aspiration was found in 176 (23.91%) patients. Conclusion: Frequency of PTX in newborn with meconium aspiration is quite high. In every newborn with meconium aspiration, proper management should be done for early prevention as well as taking therapeutic measures in this particular population.

show abstract

“…The literature generally shows an incidence of CDH at 1.4/1000 births and 0.9–1.1/1000 live births [ 4 ]. Other authors found an incidence of about 10–11/10,000 live births, but the consensus is that lung hypoplasia is generally underdiagnosed [ 5 ]. Mortality rates tend to be high, depending on the severity.…”

Section: Introductionmentioning

confidence: 99%

The Necessity of Magnetic Resonance Imaging in Congenital Diaphragmatic Hernia

Neştianu

Brădeanu²,

Alexandru

et al. 2022

Diagnostics

View full text Add to dashboard Cite

This is a retrospective study investigating the relationship between ultrasound and magnetic resonance imaging (MRI) examinations in congenital diaphragmatic hernia (CDH). CDH is a rare cause of pulmonary hypoplasia that increases the mortality and morbidity of patients. Inclusion criteria were: patients diagnosed with CDH who underwent MRI examination after the second-trimester morphology ultrasound confirmed the presence of CDH. The patients came from three university hospitals in Bucharest, Romania. A total of 22 patients were included in the study after applying the exclusion criteria. By analyzing the total lung volume (TLV) using MRI, and the lung to head ratio (LHR) calculated using MRI and ultrasound, we observed that LHR can severely underestimate the severity of the pulmonary hypoplasia, even showing values close to normal in some cases. This also proves to be statistically relevant if we eliminate certain extreme values. We found significant correlations between the LHR percentage and herniated organs, such as the left and right liver lobes and gallbladder. MRI also provided additional insights, indicating the presence of pericarditis or pleurisy. We wish to underline the necessity of MRI follow-up in all cases of CDH, as the accurate measurement of the TLV is important for future treatment and therapeutic strategy.

show abstract

Pulmonary hypoplasia: An analysis of cases over a 20-year period

Cited by 12 publications

References 33 publications

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Pneumothorax in neonates with meconium aspiration.

The Necessity of Magnetic Resonance Imaging in Congenital Diaphragmatic Hernia

Contact Info

Product

Resources

About