Pulmonary infection with Mycobacterium gordonae in the presence of bronchial carcinoma

Clague, H. W.; Hopkins, C.A.; Roberts, C.; Jenkins, Peter

doi:10.1016/0041-3879(85)90055-8

Cited by 13 publications

(15 citation statements)

References 4 publications

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“…Of 17 reports of non-AIDS cases, 8 contained insufficient evidence to conclude that the scotochromogen that was isolated, regardless of its identity, was actually causing disease (21,71,113,117,130,170). In the remaining nine cases, in which the Mycobacterium species isolated did appear to be playing a role in the disease, five of the scotochromogens isolated were insufficiently described to confirm their identity as a typical M. gordonae (14,31,100,126,194); one of the isolates, from the peritoneal dialysis patient (111) (155,175). Despite the limited features that can be used to distinguish among these three species (205,224), there is sufficient phenotypic distinction, as recognized in numerical taxonomic matrices (125,220), to meet the recommended (208) support for their nucleic acidbased separation (155,175).…”

Section: Species Of Mycobacteria Generallymentioning

confidence: 98%

“…Of two patients with lung lesions attributed to M. gordonae, one yielded multiple isolates of the organism from sputum (31), but the strain was not described in detail; in the other patient, the strain was isolated from a resected nodule (35) and was urease positive, which is very unusual for M. gordonae. Four isolations from pleural effusions have been reported (71): two associated with malignant disease, one associated with congestive heart failure, and the other of unknown origin but which resolved without treatment.…”

Section: Species Of Mycobacteria Generallymentioning

confidence: 99%

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Agents of newly recognized or infrequently encountered mycobacterial diseases

1992

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This paper reviews recent information on the systematics and clinical significance of potentially pathogenic environmental mycobacteria. A short history of these mycobacteria is given. Information on species for which clinical and systematic aspects have already been well documented, i.e., Mycobacterium kansasii, M. marinum, M. scrofulaceum, M. simiae, M. szulgai, M. ulcerans, M. xenopi, and members of the M. fortuitum complex, is updated. Although the M. avium complex was extensively reviewed in earlier literature, major new systematic and clinical information is presented in some detail. Species that have received very limited prior coverage, i.e., M. asiaticum, M. haemophilum, M. malmoense, and M. shimoidei, are the main subjects of this review and are discussed in detail. The rare infections attributed to species that are normally considered nonpathogenic, i.e., M. gastri, M. gordonae, the M. terrae complex, and most of the rapidly growing mycobacteria outside of the M. fortuitum complex, are critically reviewed. Finally, suggestions are offered for practical measures that can minimize the risk of failing to isolate or misidentifying some of the more obscure potentially pathogenic environmental mycobacteria that are only infrequently recognized.

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Section: Species Of Mycobacteria Generallymentioning

confidence: 98%

Section: Species Of Mycobacteria Generallymentioning

confidence: 99%

Agents of newly recognized or infrequently encountered mycobacterial diseases

1992

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“…Two cases involved immunocompromised patients: 1 pa tient had AIDS [10], the other had Hodgkin's disease [II]. Five other cases report M. gordonae as the prob able cause of infiltrative and even cavitary lung dis ease [12][13][14][15]. In all but 1 of these cases, the diagnosis was made on the basis of positive sputum cultures and an abnormal chest X-ray which improved with treat ment.…”

Section: Case Reportmentioning

confidence: 99%

A Solitary Pulmonary Nodule due to <i>Mycobacterium gordonae</i>

Collop¹

1990

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“…Although M. gordonae is considered to be non-pathogenic, there have been some well-documented cases of infections caused by this organism in patients with underlying conditions, e.g. AIDS or cancer (Bernard et al, 1992 ;Clague et al, 1985 ;London et al, 1988 ;Rusconi et al, 1997).…”

Section: Abbreviations : Ei-ms Electron-impact Ms ; Fab-ms Fast-atomentioning

confidence: 99%

The HPLC-double-cluster pattern of some Mycobacterium gordonae strains is due to their dicarboxy-mycolate content

et al. 2002

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The mycolic acids of several strains of Mycobacterium gordonae were examined by chromatographic and spectroscopic techniques. Both HPLC and TLC revealed two patterns of mycolates among the M. gordonae strains studied. As determined by TLC, one pattern was composed of α-, methoxy-and keto-mycolates ; the other was composed of these mycolates plus an additional component, which was identified as dicarboxy-mycolates. The dicarboxymycolates were only found in those M. gordonae strains that displayed a so-called HPLC-double-cluster pattern. Detailed structural analyses of the dicarboxy-mycolates indicated that these compounds contained predominantly 61-65 carbon atoms (C 63 was the major component) and a trans-1,2-disubstituted cyclopropane ring. Thus, the dicarboxy-mycolate content of strains of M. gordonae determines their HPLC pattern. In spite of the differences in their HPLC patterns, and although they belonged to different PCR-restriction length polymorphism clusters, all of the M. gordonae strains examined in this study were closely related on the basis of the structural features of their α-, keto-and methoxy-mycolates ; the predominant α-mycolates contained two cis-1,2-disubstituted cyclopropane rings, the major keto-mycolates contained a trans-1,2-disubstituted cyclopropane ring and the methoxy-mycolates contained one cis-or one trans-1,2-disubstituted cyclopropane ring. It is noteworthy that the strains containing dicarboxymycolates also displayed significant amounts of α-mycolates that contained one cis-1,2-disubstituted cyclopropane ring and one cis double bond. The results obtained in this study demonstrate heterogeneity among M. gordonae strains.

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Pulmonary infection with Mycobacterium gordonae in the presence of bronchial carcinoma

Cited by 13 publications

References 4 publications

Agents of newly recognized or infrequently encountered mycobacterial diseases

Agents of newly recognized or infrequently encountered mycobacterial diseases

A Solitary Pulmonary Nodule due to <i>Mycobacterium gordonae</i>

The HPLC-double-cluster pattern of some Mycobacterium gordonae strains is due to their dicarboxy-mycolate content

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