Pulmonary infections in lung cancer patients at diagnosis

Putinati, S; Trevisani, Lucio; Gualandi, Malvina; Guerra, Giovanni; Rossi, Maria Rita; Sartori, Sergio; Potena, A

doi:10.1016/0169-5002(94)90544-4

Cited by 20 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although adenocarcinoma or squamous cell carcinoma were recorded in nearly 80% of patients, no significant association was found between any histological type of cancer and colonisation, as has been reported previously [4,11], although squamous cell carcinoma patients tended to be colonised more often than others.…”

Section: Discussionmentioning

confidence: 55%

“…Despite substantial improvements in the diagnosis and therapeutic management of the different histological types of lung cancer, morbidity and mortality are still high, notably due to pulmonary infectious complications, which account for 35-70% of cases [2][3][4]. Radioclinical presentations range from bronchitis to septicaemia, including pneumonia and empyema.…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that bronchial colonisation plays a key role in the establishment of pulmonary infections in patients with lung cancer, and thus clearly influences the therapeutic management and probably the prognosis of cancer [3,4,6,7]. In such patients, colonisation may arise following local bronchial impairment, e.g.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bronchial colonisation in patients with lung cancer: a prospective study

et al. 2012

View full text Add to dashboard Cite

Bronchial colonisation is frequently reported in patients with lung cancer, and has a potential impact on therapeutic management and prognosis. We aimed to prospectively define the prevalence and nature of bronchial colonisation in patients at the time of diagnosing lung cancer.210 consecutive patients with lung cancer underwent a flexible bronchoscopy for lung cancer. The type and frequency of bacterial, mycobacterial and fungal colonisation were analysed and correlated with the patients' and tumours' characteristics.Potential pathogens were found in 48.1% of samples: mainly the Gram-negative bacilli Escherichia coli (8.1%), Haemophilus influenzae (4.3%) and Enterobacter spp. (2.4%); Gram-positive cocci, Staphylococcus spp. (12.9%) and Streptococcus pneumoniae (3.3%); atypical mycobacteria (2.9%); Candida albicans (42.9%); and Aspergillus fumigatus (6.2%). Aged patients (p50.02) with chronic obstructive pulmonary disease (p50.008) were significantly more frequently colonised; however, tumour stage, atelectasis, bronchial stenosis and abnormalities of chest radiography were not associated with a higher rate of colonisation. Squamous cell carcinoma tended to be more frequently colonised than other histological subtypes. Airway colonisation was reported in almost half of patients presenting with lung cancer, mainly in fragile patients, and was significantly associated with worse survival (p50.005).Analysing colonisation status of patients at the time of diagnosis may help improve the management of lung cancer. @ERSpublications Characteristics and impact of bronchial colonisation in patients at the time of lung cancer diagnosis

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bronchial colonisation in patients with lung cancer: a prospective study

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Informed consent was obtained from all patients. Pneumonia, including nosocomial pneumonia, is one of the main complications occurring in lung cancer patients due to defects in the clearance system in sites peripheral to the bronchial obstruction, or stenosis caused by cancer therapy as well as cancer itself and broad-spectrum antibiotics usage [7][8][9][10][11][12][13][14]. The role of anaerobes in the pathogenesis of pneumonia in hospitalized patients, especially in critically or chronically ill patients, is still controversial [4,15,16].…”

mentioning

confidence: 99%

Anaerobic bacteria colonizing the lower airways in lung cancer patients

Rybojad¹,

Łoś²,

Sawicki³

et al. 2011

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Abstract:Abstract: Abstract: Abstract: Abstract: Anaerobes comprise most of the endogenous oropharyngeal microflora, and can cause infections of airways in lung cancer patients who are at high risk for respiratory tract infections. The aim of this study was to determine the frequency and species diversity of anaerobes in specimens from the lower airways of lung cancer patients. Sensitivity of the isolates to conventional antimicrobial agents used in anaerobe therapy was assessed. Respiratory secretions obtained by bronchoscopy from 30 lung cancer patients were cultured onto Wilkins--Chalgren agar in anaerobic conditions at 37°C for 72-96 hours. The isolates were identified using microtest Api 20A. The minimal inhibitory concentrations for penicillin G, amoxicillin/clavulanate, piperacillin/tazobactam, cefoxitin, imipenem, clindamycin, and metronidazole were determined by E-test. A total of 47 isolates of anaerobic bacteria were detected in 22 (73.3%) specimens. More than one species of anaerobe was found in 16 (53.3%) samples. The most frequently isolated were Actinomyces spp. and Peptostreptococcus spp., followed by Eubacterium lentum, Veillonella parvula, Prevotella spp., Bacteroides spp., Lactobacillus jensenii. Among antibiotics used in the study amoxicillin/clavulanate and imipenem were the most active in vitro (0% and 2% resistant strains, respectively). The highest resistance rate was found for penicillin G and metronidazole (36% and 38% resistant strains, respectively). The results obtained confirm the need to conduct analyses of anaerobic microflora colonizing the lower respiratory tract in patients with lung cancer to monitor potential etiologic factors of airways infections, as well as to propose efficient, empirical therapy. (Folia Histochemica et

show abstract

“…Regardless of the histologic type, patients with lung cancer frequently suffer from pulmonary infections which are associated with a reduction in median survival (1). The most frequent pathogens found in patients with lung cancer are Gram-negative bacteria such as Haemophilus influenzae and Escherichia coli, and an increase in Gram-positive infections, especially with Streptococcus pneumoniae and Staphylococcus aureus has been observed recently (2,3). The use of antibiotics, especially clarithromycin, has profitable effects on survival and tumor progression in NSCLC (4).…”

Section: Introductionmentioning

confidence: 99%

Amplification of Lipopolysaccharide-Induced Cytokine Synthesis in Non–Small Cell Lung Cancer/Neutrophil Cocultures

Grandel¹,

Heygster²,

Sibelius³

et al. 2009

Molecular Cancer Research

View full text Add to dashboard Cite

Proinflammatory cytokines are centrally involved in tumor progression and survival in non-small cell lung cancer, and both the presence of infiltrating neutrophils and bacterial infection in the lung may indicate a poor prognosis. Against this background, we investigated the effect of the bacterial cell wall component lipopolysaccharide (LPS) on interleukin (IL)-6 and IL-8 synthesis in the non-small cell lung cancer line A549 and in A549-neutrophil cocultures. The LPS induced a dose-dependent and time-dependent release of IL-8 from A549 cells, whereas IL-6 could not be detected. Interestingly, in A549-neutrophil cocultures, IL-8 synthesis was massively amplified and IL-6 was also released, compared with the respective monocultures. The A549 cells were identified as the primary cellular source of these cytokines, as enhanced cytokine mRNA transcription was detected in this cell type, although not in neutrophils in the coculture system. Experiments done in transwells indicated that direct cell-cell contact was a prerequisite for the increased cytokine generation. Inhibition of tumor necrosis factor-α bioactivity by neutralizing antibodies and blocking cyclooxygenase-2 activity blunted the enhanced cytokine generation in the coculture system. Amplification of LPS-induced cytokine secretion could be reproduced when the small cell lung cancer cell line H69 was cocultured with neutrophils. When the Gram-positive cell wall component lipoteichoic acid was used instead of LPS, cytokine synthesis was also amplified in A549-neutrophil cocultures, to a similar extent to that observed with LPS. These data indicate that interaction between bacterial pathogens, neutrophils, and tumor cells might amplify the release of proinflammatory cytokines which may promote tumor growth in vivo.

show abstract

Pulmonary infections in lung cancer patients at diagnosis

Cited by 20 publications

References 18 publications

Bronchial colonisation in patients with lung cancer: a prospective study

Bronchial colonisation in patients with lung cancer: a prospective study

Anaerobic bacteria colonizing the lower airways in lung cancer patients

Amplification of Lipopolysaccharide-Induced Cytokine Synthesis in Non–Small Cell Lung Cancer/Neutrophil Cocultures

Contact Info

Product

Resources

About