Pulmonary Infiltration with Eosinophilia and Increased Serum Levels of Squamous Cell Carcinoma-Related Antigen and Neuron Specific Enolase.

Abstract

Wereport a case of pulmonary infiltration with eosinophilia (PIE), associated with increased serum levels of squamous cell carcinoma-related antigen (SCC) and neuron specific enolase (NSE). The diagnosis of PIE was confirmed by examination ofbronchoalveolar lavage fluid and specimens of transbronchial lung biopsy. It was suggested that PIE was probably induced by a course of amoxicillin for a sore throat. Corticosteroid therapy resulted in clinical improvement of symptoms, resolution of pulmonary infiltrates on chest roentgenogram and reduction in serum levels of SCC andNSE. (Internal Medicine 33: 550-553, 1994)

Amoxicillin-Induced Eosinophilic Pneumonia with Granulomatous Reaction: Discrepancy between Drug-Induced Lymphocyte Stimulation Test Findings and the Provocation Drug Test

“…There are several reports of penicillin-induced eosinophilic pneumonia [2-5,7], but amoxicillin-induced eosinophilic pneumonia is very rare, with only one reported case in the literature that was diagnosed based on a DLST [7]. …”

“…DLST demonstrates the specificity of the T-cell reaction to the drug. In Japan, drug-induced pneumonia and liver injury are diagnosed on the basis of DLST results [4,5,7,8], although a drug provocation test is the most reliable method for diagnosing a drug allergy [11]. Recent reports, however, indicate that the DLST is unreliable for the diagnosis of drug-induced liver injury [11].…”

“…Drug-induced pneumonia, however, is relatively rare [2-5]. There are only a few reports of the clinical manifestations of penicillin-induced eosinophilic pneumonia [6,7]. A drug-induced lymphocyte stimulation test (DLST) measures the proliferation of T cells in response to a drug in vitro.…”

Adult Respiratory Distress Syndrome with Increased Serum and Bronchoalveolar Lavage Fluid Levels of Squamous Cell Carcinoma-Related Antigen.

“…However, serum levels of SCChave also been reported to be elevated in nonmalignant disease (2,3). Furthermore, mononuclear cell-related cytokines can stimulate the production of SCCantigen from normal squamousepithelium (4).…”

Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract

“…Serum levels of this antigen in those patients with gynecologic, head and neck (HN), lung, and esophageal SCCs are elevated, and the SCC antigen has been well used as a tumor marker against SCC patients 8–14. However, serum levels of this antigen also have been reported to be elevated in patients with nonmalignant skin or lung disease 15–25…”