Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training

Michelotto, Pedro Vicente; Muehlmann, Luís Alexandre; Zanatta, Ana L.; Bieberbach, Eloyse W.R.; Kryczyk, Marcelo; Fernandes, Luís Filipe Sanches; Nishiyama, Anita

doi:10.1016/j.tvjl.2010.08.009

Cited by 15 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in neutrophil counts for EIPH-positive animals was also found [12, 14, 23]. This result may vary due to differences in the tracheal lavage collection period after the exercise, as well as the place where the procedure was performed.…”

Section: Discussionmentioning

confidence: 87%

Association between exercise-induced pulmonary hemorrhage and inflammatory airway disease in polo ponies

Silva

Otaka

Gonçalves

et al. 2017

JES

View full text Add to dashboard Cite

The respiratory system is essential for health and high athletic performance in horses. Respiratory diseases have been recognized as having a major impact on training equine animals and are commonly cited as the second most common cause of wasted training time. Inflammatory airway disease (IAD) is an important cause of poor performance in young racehorses. Exercise-induced pulmonary hemorrhage (EIPH) is considered a major issue for the equine industry because of its high prevalence and association with reduced athletic performance. In Brazil, polo is a growing equestrian sport, but studies on it are still scarce. The aim of this study was to evaluate the occurrence of EIPH, the association between EIPH and IAD, and EIPH influence on the tracheal cytological profile of polo ponies. Thirty-seven horses regularly used for polo were included in this study. Endoscopic examination was performed every 30 to 90 min after practice, and tracheal lavage was performed after 18 to 24 hr. Sixteen animals (43.2%) presented a score of 0 for mucus in endoscopy; twelve animals (32.4%) presented a score for 1 and nine animals (24.3%) presented score 2 of mucus. IAD was characterized by tracheal cytology in 12 animals (32.4%). The occurrence of EIPH in this study was 29.7% (11/37). No significant difference was found in the cell types in tracheal cytology when EIPH-positive and EIPH-negative horses were compared. Polo ponies are affected by IAD and EIPH in relevant proportions, but there was no association between EIPH and tracheal cytological profile.

show abstract

Section: Discussionmentioning

confidence: 87%

Association between exercise-induced pulmonary hemorrhage and inflammatory airway disease in polo ponies

Silva

Otaka

Gonçalves

et al. 2017

JES

View full text Add to dashboard Cite

show abstract

“…In the horse, higher TNCC counts were identified in young adult horses compared to an older age group in a prior study . Additionally, Thoroughbred colts in training have been shown to have higher BALF TNCC counts, as well as an increased percentage of neutrophils and eosinophils, when compared with stabled colts of similar age . In this context, it is important for clinicians and clinical pathologists to recognize that although an increase in TNCC can occur with airway inflammation in horses, it is not specific for inflammation and should be interpreted in conjunction with the signalment, history, and clinical signs.…”

Section: Discussionmentioning

confidence: 95%

Age‐related variation in the cellular composition of equine bronchoalveolar lavage fluid

Hostetter

Clark

Gilbertie

et al. 2017

Veterinary Clinical Pathol

View full text Add to dashboard Cite

show abstract

“…It can lead to progressively decreased athletic performance [155][156][157][158][159][160][161]. EIPH causes persistent structural lung damage with fibrosis and vascular remodeling of the caudodorsal lung fields, as well as venous remodeling and occasional bronchiolar damage [156,157,[159][160][161][162]. This, in turn, leads to pulmonary hypertension, capillary stress failure and hemorrhage into the lung.…”

Section: Preclinical Studies Of Msc Therapy In Acute Lung Injury (Ali)mentioning

confidence: 99%

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

et al. 2020

View full text Add to dashboard Cite

In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the World Health Organization declared that the rapidly spreading viral outbreak had become a global pandemic. Coronavirus disease 2019 (COVID-19) is typically associated with fever and respiratory symptoms. It often progresses to severe respiratory distress and multi-organ failure which carry a high mortality rate. Older patients or those with medical comorbidities are at greater risk for severe disease. Inflammation, pulmonary edema and an over-reactive immune response can lead to hypoxia, respiratory distress and lung damage. Mesenchymal stromal/stem cells (MSCs) possess potent and broad-ranging immunomodulatory activities. Multiple in vivo studies in animal models and ex vivo human lung models have demonstrated the MSC's impressive capacity to inhibit lung damage, reduce inflammation, dampen immune responses and aid with alveolar fluid clearance. Additionally, MSCs produce molecules that are antimicrobial and reduce pain. Upon administration by the intravenous route, the cells travel directly to the lungs where the majority are sequestered, a great benefit for the treatment of pulmonary disease. The in vivo safety of local and intravenous administration of MSCs has been demonstrated in multiple human clinical trials, including studies of acute respiratory distress syndrome (ARDS). Recently, the application of MSCs in the context of ongoing COVID-19 disease and other viral respiratory illnesses has demonstrated reduced patient mortality and, in some cases, improved long-term pulmonary function. Adipose-derived stem cells (ASC), an abundant type of MSC, are proposed as a therapeutic option for the treatment of COVID-19 in order to reduce morbidity and mortality. Additionally, when proven to be safe and effective, ASC treatments may reduce the demand on critical hospital resources. The ongoing COVID-19 outbreak has resulted in significant healthcare and socioeconomic burdens across the globe. There is a desperate need for safe and effective treatments. Cellular based therapies hold great promise for the treatment of COVID-19. This literature summary reviews the scientific rationale and need for clinical studies of adipose-derived stem cells and other types of mesenchymal stem cells in the treatment of patients who suffer with COVID-19.

show abstract

Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training

Cited by 15 publications

References 38 publications

Association between exercise-induced pulmonary hemorrhage and inflammatory airway disease in polo ponies

Association between exercise-induced pulmonary hemorrhage and inflammatory airway disease in polo ponies

Age‐related variation in the cellular composition of equine bronchoalveolar lavage fluid

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

Contact Info

Product

Resources

About