2023
DOI: 10.1097/ee9.0000000000000271
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Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD

Erin G. McHugh,
Stephanie T. Grady,
Christina M. Collins
et al.

Abstract: Introduction: Indoor nitrogen dioxide (NO2) sources include gas heating, cooking, and infiltration from outdoors. Associations with pulmonary function, systemic inflammation, and oxidative stress in patients with chronic obstructive pulmonary disease (COPD) are uncertain. Methods: We recruited 144 COPD patients at the VA Boston Healthcare System between 2012 and 2017. In-home NO2 was measured using an Ogawa passive sampling badge for a week seasonally f… Show more

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“…NO 2 inhaled into alveoli dissolves and produces reactive oxygen species (ROS) and nitrogen substances, inducing oxidative stress and respiratory tract damage [4]. Oxidative stress increased by the generation of ROS and reactive nitrogen species induces chronic inflammation [50]. NO 2 levels are strongly associated with an increased risk of asthma exacerbation [51].…”
Section: Discussionmentioning
confidence: 99%
“…NO 2 inhaled into alveoli dissolves and produces reactive oxygen species (ROS) and nitrogen substances, inducing oxidative stress and respiratory tract damage [4]. Oxidative stress increased by the generation of ROS and reactive nitrogen species induces chronic inflammation [50]. NO 2 levels are strongly associated with an increased risk of asthma exacerbation [51].…”
Section: Discussionmentioning
confidence: 99%