Pulmonary interstitial emphysema in preterm twins on continuous positive airway pressure

Arioni, Cesare; Bellini, Carlo; Scopesi, F.; Mazzella, Massimo; Serra, G.

doi:10.1080/14767050600853344

Cited by 5 publications

(1 citation statement)

References 8 publications

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“… 11 However, several authors report on the spontaneous evolution of PIE in preterm neonates even in the absence of invasive ventilation, including a set of twin VLBWI. 9 12 13 14 Prior to the development of PIE, all these cases reported in the literature had clinical and radiological signs of RDS, but were never treated with surfactant. Thus, it is unclear if mechanical ventilation is the main driver in the etiology of PIE or whether early PIE is rather the consequence of missed or delayed surfactant administration.…”

Section: Discussionmentioning

confidence: 99%

Early Pulmonary Interstitial Emphysema in Preterm Neonates—Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins

Gronbach

Ehrhardt

Zimmer

et al. 2018

AJP Rep

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Early pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during noninvasive respiratory support. We further review the current evidence from the literature, specifically addressing on possible preventive measures and the respiratory management options of this acute pulmonary disease in high-risk neonates.

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