Pulmonary intravascular macrophages as proinflammatory cells in heaves, an asthma-like equine disease

Aharonson-Raz, Karin; Lohmann, Katharina L.; Townsend, H. G. G.; Marqués, Fernando; Singh, Baljit

doi:10.1152/ajplung.00271.2011

Cited by 14 publications

(3 citation statements)

References 50 publications

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“…Depletion of equine PIMs by gadolinium chloride resulted in a decreased severity of LPS‐induced lung inflammation, reflected in a reduced mean pulmonary arterial pressure and lower IL‐1B production in PIM‐depleted horses compared to controls 196 . Furthermore, depletion of PIMs in horses affected with SEA resulted in a reduction in both clinical symptoms and lung inflammation, characterised by a reduced airway neutrophil count and a decrease in IL8 and TLR4 mRNA detected in airway‐derived cells 197 . Equine PIMs have been shown to express TLR4 and TLR9, and the expression of TLR2, TLR4 and TLR9 in horse lungs was augmented after LPS treatment 185,191 .…”

Section: The Mononuclear Phagocyte System Of the Horsementioning

confidence: 96%

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Karagianni

Lisowski

Hume

et al. 2020

Equine Veterinary Journal

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Horses are already recognised as models for several human diseases, including metabolic syndrome, asthma, musculoskeletal diseases, melanoma and autoimmune uveitis. 1-6 More than 100 equine hereditable conditions may serve as models for human disorders, including inflammation, muscular or fertility disorders, osteoarthritis and even depression. 7-10 The horse has the potential to represent an appropriate

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Section: The Mononuclear Phagocyte System Of the Horsementioning

confidence: 96%

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Karagianni

Lisowski

Hume

et al. 2020

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Heaves is a recurrent neutrophilic lung disease in horses with clinical similarity to asthma [ 70 ] but likely caused by molds from airborne dust and not by pollen [ 71 ]. Interestingly, an enhanced apoptosis rate in CD4 and CD8 T-cells are seen in horses affected by RAO [ 72 ].…”

Section: Reviewmentioning

confidence: 99%

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

Jensen‐Jarolim

Einhorn

Herrmann

et al. 2015

Clinical & Translational All

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Both humans and their most important domestic animals harbor IgE and a similar IgE receptor repertoire and expression pattern. The same cell types are also involved in the triggering or regulation of allergies, such as mast cells, eosinophils or T-regulatory cells. Translational clinical studies in domestic animals could therefore help cure animal allergies and at the same time gather knowledge relevant to human patients. Dogs, cats and horses may spontaneously and to different extents develop immediate type symptoms to pollen allergens. The skin, nasal and bronchial reactions, as well as chronic skin lesions due to pollen are in principle comparable to human patients. Pollen of various species most often causes allergic rhinitis in human patients, whereas in dogs it elicits predominantly eczematous lesions (canine atopic dermatitis), in horses recurrent airway obstruction or hives as well as pruritic dermatitis, and in cats bronchial asthma and so-called cutaneous reactive patterns (eosinophilic granuloma complex, head and neck pruritus, symmetric self-induced alopecia). In human allergy-specific IgE detection, skin tests or other allergen provocation tests should be completed. In contrast, in animals IgE and dermal tests are regarded as equally important and may even replace each other. However, for practical and economic reasons intradermal tests are most commonly performed in a specialized practice. As in humans, in dogs, cats and horses allergen immunotherapy leads to significant improvement of the clinical symptoms. The collected evidence suggests that canines, felines and equines, with their spontaneous allergies, are attractive model patients for translational studies.

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“…Na medicina humana também é de grande relevância a ocorrência de doenças inflamatórias no sistema respiratório (VIEGI et al, 2001;HOLMBERG et al, 2015;LIU et al, 2015;PATEL et al, 2015), cuja patogenia se assemelha em muitos aspectos às afecções deste gênero em equinos (AHARONSON-RAZ et al, 2012; BULLONE; LAVOIE, 2015) e o tratamento também se baseia muitas vezes na corticoterapia (WELTE, 2009;DURHAM et al, 2015). Entretanto, na medicina humana a principal via de administração utilizada nesses casos é a inalatória, pois assim é possível aumentar a concentração local do fármaco sem aumentar a sua concentração sistêmica, otimizando o seu efeito no sítio desejado e minimizando os efeitos colaterais (ALLEN et al, 2003;BECKHAUS;RIUTORT;CASTRO-RODRIGUEZ, 2014;LOYMANS et al, 2014).…”

Section: Curvas Analíticasunclassified

<b>Avaliação da deposição pulmonar da dexametasona quando administrada por via inalatória em equinos</b>

Hilgert¹

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Pulmonary intravascular macrophages as proinflammatory cells in heaves, an asthma-like equine disease

Abstract: Aharonson-Raz K, Lohmann KL, Townsend HG, Marques F, Singh B. Pulmonary intravascular macrophages as proinflammatory cells in heaves, an asthma-like equine disease.

Cited by 14 publications

References 50 publications

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Pollen Allergies in Humans and their Dogs, Cats and Horses: Differences and Similarities

<b>Avaliação da deposição pulmonar da dexametasona quando administrada por via inalatória em equinos</b>

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