Pulmonary Involvement in Mixed Connective Tissue Disease

Derderian, Sarkis S.; Tellis, Claude J.; Abbrecht, Peter H.; Welton, Richard C.; Rajagopal, Krishnan R.

doi:10.1378/chest.88.1.45

Cited by 35 publications

(17 citation statements)

References 13 publications

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“…Patients with MCTD typically had high serum titres of antibody to extractable nuclear antigen (anti‐nRNP Ab), a feature that has become the hallmark of this syndrome 2 . Although not originally recognized, pleuropulmonary manifestation is clearly now a major feature of MCTD, with a reported prevalence of 20–87% 3–6 . Most of the pleuropulmonary manifestations, both clinical and pathophysiological, are similar to those observed in SLE, SSc, and PM–DM 6–9 .…”

Section: Introductionmentioning

confidence: 96%

Bronchoalveolar lavage fluid cells in mixed connective tissue disease

et al. 2003

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Section: Introductionmentioning

confidence: 96%

Bronchoalveolar lavage fluid cells in mixed connective tissue disease

et al. 2003

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“…In adult rheumatic arthritis (RA), for example, mild restrictive defects, diffuse interstitial lung disease, as well as pulmonary vasculitis and bronchiolitis obliterans have been described [4–10]. Furthermore, interstitial lung disease represents one of the most common features in adult connective tissue disease [11]. Also, in childhood connective tissue disease functional lung impairment has been shown, even in the absence of abnormalities on chest radiographs [12, 13].…”

mentioning

confidence: 99%

Lung function abnormalities and respiratory muscle weakness in children with juvenile chronic arthritis

Knook¹,

Kleer²,

Ent³

et al. 1999

Eur Respir J

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In contrast to adult rheumatoid arthritis (RA) little is known about the prevalence, nature and cause of lung function abnormalities in children with juvenile chronic arthritis (JCA). The aim of this study was to determine whether children with polyarticular and systemic onset JCA have lung function abnormalities and if so, whether they are related to pulmonary disease, thoracic and/or muscular involvement. We determined lung function and disability in 31 children with polyarticular and systemic JCA. Respiratory muscle function, thorax expansion and spine mobility were determined in the same patients, as well as in 32 matched healthy children. Peak expiratory flow (PEF) and forced vital capacity (FVC) were significantly reduced in JCA patients, when compared to reference values. Thorax expansion and spine mobility were normal, compared to paired controls. Maximum inspiratory (PI,max) and expiratory (PE,max) pressures were significantly reduced in patients compared to paired control subjects. A positive correlation was found between PE,max and FVC and PEF, an inverse correlation between expiratory pressure and disability. In conclusion, children with polyarticular and systemic juvenile chronic arthritis show a pronounced impairment in respiratory muscle strength, severe enough to cause mild lung function abnormalities and an increase in disability‐scores.

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“…There were 6 patients (35%) who had received ; it has been thought to be the most common dysfunction in MCTD, although a few authors have suggested impaired small airway function. Similarly, Derderian et al (1985) suggested that diffusing capacity was the most sensitive parameter, though they found frequency dependence of dynamic compliance in patients with MCTD. In the present study, there were few significant differences between the first and the last pulmonary function tests, which were carried out at intervals %DLCO and disease duration.…”

Section: Resultsmentioning

confidence: 99%

“…Pulmonary function tests in these patients, especially in those with PSS and RA, often show restrictive and/or obstructive damage and, recently, small airway impairments (Collins et al 1976; Guttadauria et al 1977; Bagg and Hughes 1979;Hills et al 1979; Hunninghake and Fauci 1979; Begin et al 1982; Mountz et al 1984). Moreover, it has been reported that diffusing capacity is frequently decreased in MCTD patients (Sharp 1974(Sharp -1975Singsen et al 1977; Wiener-Kronish et al 1981; Sullivan et al 1984; Takasaki et al 1984; Derderian et al 1985; Prakash et al 1985), but there are few studies concerning the small airways. Small airway diseases have been reported to be common in interstitial pneumonia (Hone et al 1983), and it is thus expected that estimation of small airway impairments may help to detect early pulmonary involvements in the disease.…”

mentioning

confidence: 99%

Small Airway Involvement in Mixed Connective Tissue Disease.

Izumiyama

Hida

Ichinose

et al. 1993

Tohoku J. Exp. Med.

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We studied pulmonary functions in 17 female patients with mixed connective tissue disease (MCTD) to detect early pulmonary involvement in this disease; in 8 of the 17 patients followup studies were also performed at 1.2-to 5.9-year intervals. In the first pulmonary function tests, decreases in vital capacity (VC) and diffusing capacity (DL~o) were observed in 6 (35%) and 8 (47%) patients, respectively. The ratio of forced expiratory volume in one second to VC was normal in all the patients, but pulmonary resistance and static compliance were abnormal in 6 (35%) and 10 (59%) patients, respectively. However, frequency dependence of dynamic compliance was found in all 16 patients tested. Moreover, 4 (24%) of the 17 patients had normal DL~o and DL~o-to-alveolar volume ratio (DLCO/VA). Reductions in DL~o and DLCo/VA were significantly correlated with the disease duration. These results suggest that small airway obstruction is an early and frequent indication of functional pulmonary impairment, and that impairment of alveolar gas exchange is progressive in patients with MCTD.connective tissue disease; small airways; frequency dependence of dynamic compliance; diffusing capacity

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Pulmonary Involvement in Mixed Connective Tissue Disease

Cited by 35 publications

References 13 publications

Bronchoalveolar lavage fluid cells in mixed connective tissue disease

Bronchoalveolar lavage fluid cells in mixed connective tissue disease

Lung function abnormalities and respiratory muscle weakness in children with juvenile chronic arthritis

Small Airway Involvement in Mixed Connective Tissue Disease.

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