Pulmonary lesions: correlative study of dynamic triple-phase enhanced CT perfusion imaging with tumor angiogenesis and vascular endothelial growth factor expression

Zou, Mingyue; Zhao, Zhenhua; Qian, Zhendong; Mao, Haijia; Huang, Yanan; Wang, Cheng

doi:10.1186/s12880-021-00692-3

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Currently, studies on the use of enhanced CT features for assessing MSI status in CRC patients have not been reported. Enhanced CT scanning is based on the formation of neovascularization of different tumours resulting in different haemodynamic changes to qualitatively analyse the lesions [ 39 ]. The CT value of the lesions is influenced by various factors, such as patient physiological factors, operator factors, and equipment factors [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Preoperative prediction of microsatellite instability status in colorectal cancer based on a multiphasic enhanced CT radiomics nomogram model

Bian,

Sun,

Wang

et al. 2024

BMC Med Imaging

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Background To investigate the value of a nomogram model based on the combination of clinical-CT features and multiphasic enhanced CT radiomics for the preoperative prediction of the microsatellite instability (MSI) status in colorectal cancer (CRC) patients. Methods A total of 347 patients with a pathological diagnosis of colorectal adenocarcinoma, including 276 microsatellite stabilized (MSS) patients and 71 MSI patients (243 training and 104 testing), were included. Univariate and multivariate regression analyses were used to identify the clinical-CT features of CRC patients linked with MSI status to build a clinical model. Radiomics features were extracted from arterial phase (AP), venous phase (VP), and delayed phase (DP) CT images. Different radiomics models for the single phase and multiphase (three-phase combination) were developed to determine the optimal phase. A nomogram model that combines clinical-CT features and the optimal phasic radscore was also created. Results Platelet (PLT), systemic immune inflammation index (SII), tumour location, enhancement pattern, and AP contrast ratio (ACR) were independent predictors of MSI status in CRC patients. Among the AP, VP, DP, and three-phase combination models, the three-phase combination model was selected as the best radiomics model. The best MSI prediction efficacy was demonstrated by the nomogram model built from the combination of clinical-CT features and the three-phase combination model, with AUCs of 0.894 and 0.839 in the training and testing datasets, respectively. Conclusion The nomogram model based on the combination of clinical-CT features and three-phase combination radiomics features can be used as an auxiliary tool for the preoperative prediction of the MSI status in CRC patients.

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Section: Discussionmentioning

confidence: 99%

Preoperative prediction of microsatellite instability status in colorectal cancer based on a multiphasic enhanced CT radiomics nomogram model

Bian,

Sun,

Wang

et al. 2024

BMC Med Imaging

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“…Most researchers now agree that the pulmonary artery generally acts only as a smaller maintenance vessel in lung cancer, whereas the bronchial artery benefits more from a significantly stronger neovascularization capacity than the pulmonary artery and becomes the main blood supply vessel in lung cancer ( 21 ). Bronchial artery blood supply accounts for the vast majority of blood supply in central or larger lung cancers, and bronchial artery blood supply increases as lung cancer grows and proliferates, making it the main source of blood supply in lung cancer ( 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Drug-eluting beads bronchial arterial chemoembolization vs. conventional bronchial arterial chemoembolization in the treatment of advanced non-small cell lung cancer

Shen

Chen

et al. 2023

Front. Med.

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PurposeTo compare the effectiveness and safety of drug-eluting bead bronchial artery chemoembolization (DEB-BACE) with conventional bronchial artery chemoembolization (cBACE) and provide a novel treatment option for advanced non-small cell lung cancer (NSCLC).MethodsPatients with advanced NSCLC underwent DEB-BACE or cBACE and were screened retrospectively. Progression-free survival (PFS) and overall survival (OS) were the primary outcome indicators, while technical success rate, objective response rate (ORR), disease control rate (DCR), and adverse events (AEs) were the secondary ones.ResultsA total of 41 patients were enrolled in the study, 12 in the DEB-BACE group and 29 in the cBACE group, according to the treatment regimen. No patient achieved complete response. Eighteen patients achieved partial response (9 in each group), 15 patients achieved stable disease (3 in the DEB-BACE group and 12 in the cBACE group), and eight patients achieved progressive disease (all in the cBACE group) when treated for 2 months. The overall ORR and DCR were 43.9% (18/41) and 80.5% (33/41), respectively. ORR and DCR in the DEB-BACE group were 50.0% (9/12) and 100.0% (12/12), respectively, while ORR and DCR in the cBACE group were 31.0% (9/29) and 72.4% (21/29), respectively. Compared to cBACE, the ORR and DCR of DEB-BACE were significantly improved (p < 0.05). The median PFS was better in the DEB-BACE group than in the cBACE group (6.95 months vs. 3.20 months, respectively, Hazard Ratio [HR] = 0.416; p = 0.005). Furthermore, the median OS was significantly better in the DEB-BACE group than in the cBACE group (28.5 months vs. 22.5 months, respectively, HR = 0.316; p = 0.020).ConclusionDEB-BACE has a good safety and therapeutic profile in advanced NSCLC and is superior to cBACE. DEB-BACE can be used as an alternative treatment option for advanced NSCLC, even in elderly patients.

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“…However, the CT perfusion or dynamic enhanced CT examination is time-consuming, and the corresponding diagnostic images are obtained later from the workstation. So even though both CT perfusion and dynamic enhanced CT examination can provide hemodynamic information for the differential diagnosis of early lymphoma from precancerous lesions, they are not performed widely in the daily practice ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions

Chen¹,

Yu²,

Zeng³

et al. 2022

Transl Cancer Res TCR

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Background In recent years, with the development of imaging technology, the accurate diagnosis of precancerous lesions of digestive system and early lymphoma has attracted wide attention in the medical field. Methods In this study, 82 patients with gastrointestinal diseases, including 32 patients with early gastrointestinal lymphoma and 50 patients with gastrointestinal precancerous lesions, underwent dynamic contrast-enhanced computed tomography (CT) scanning. The difference ( δ 1, δ 2) and ratio ( Q1 , Q2 ) of density between arterial phase, portal phase and plain scan were measured and compared, and the receiver operating characteristic (ROC) curve of the subjects was drawn. Results The results showed no statistically significant differences in the general condition of patients or a difference for the results of the arterial phase δ 1 and Q1 between the two groups (P>0.05). However, the portal venous phase δ 2 and Q2 in the early lymphoma group and in precancerous lesion group were 29.50±6.05, 41.55±10.10 Hounsfield units (HU), and 1.70±0.05, 2.06±0.31, respectively. The area under the ROC curve (AUC) values for δ 2 and Q2 to identify the two diseases were 0.755 and 0.878, respectively. When δ 2 and Q2 were 35.63 and 1.86 HU, the specificity was 89.60% and 67.50%, and sensitivity was 89.60% and 64.90%, respectively. When the two indexes, δ 2 and Q2 , were combined, the specificity and sensitivity of diagnosis were 98.99% and 56.80%, respectively. Conclusions Dynamic contrast-enhanced CT can effectively distinguish early gastrointestinal lymphoma from precancerous lesions and improve the diagnostic accuracy.

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Pulmonary lesions: correlative study of dynamic triple-phase enhanced CT perfusion imaging with tumor angiogenesis and vascular endothelial growth factor expression

Cited by 6 publications

References 35 publications

Preoperative prediction of microsatellite instability status in colorectal cancer based on a multiphasic enhanced CT radiomics nomogram model

Preoperative prediction of microsatellite instability status in colorectal cancer based on a multiphasic enhanced CT radiomics nomogram model

Drug-eluting beads bronchial arterial chemoembolization vs. conventional bronchial arterial chemoembolization in the treatment of advanced non-small cell lung cancer

Diagnostic test of dynamic computed tomography in early gastrointestinal lymphoma and precancerous lesions

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