Pulmonary Localization of Phosphate Bone Agents in a Case of Metastatic Breast Carcinoma

Over the past 5 years, we have encountered 6 cases of diffuse pulmonary uptake of 99m-Tc bone-scanning agents (incidence, 0.04%). To assess the significance of this phenomenon, we reviewed all of the cases reported since 1974 (Including our series, a total of 32 cases). Three groups can be discerned, the first consisting of 24 patients without radiological calcifications in the lungs and with hypercalcemia of different origins (mostly hyperparathyroidism). Of the eight autopsies performed in this group, seven revealed extensive calcifications in alveolar walls and lung vessels; the other autopsy showed no calcification at all and only bronchopneumonic lesions. The second group consists of 6 patients in chronic dialysis. The last group consists of 2 patients having diffuse pulmonary alveolar microlithiasis with extensive radiologic calcifications. The mechanism of lung uptake of 99m-Tc bone-imaging agents is probably the same as that of bone uptake (chemisorption on hydroxyapatite crystals), although other uptake mechanisms have also been discussed. Bone scintigraphy can be useful in the detection of early pulmonary calcifications, which have been associated with impaired pulmonary function and, due to their size, are generally not detected by X-ray.

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Diffuse pulmonary uptake of 99mTc bone-imaging agents: Case report and survey

Coolens

Devos

Roo

1985

Eur J Nucl Med

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Pulmonary Localization of Phosphate Bone Agents in a Case of Metastatic Breast Carcinoma

Abstract: A case of breast carcinoma with bone and cartilaginous metaplasia is reported. Metastatic pulmonary localizations were revealed through routine bone scan. Histologic rarity but, above all, the uncommon bone scan findings are emphasized.

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Diffuse pulmonary uptake of 99mTc bone-imaging agents: Case report and survey

Diffuse pulmonary uptake of 99mTc bone-imaging agents: Case report and survey

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