1989
DOI: 10.1002/ppul.1950060413
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Pulmonary manifestations of immune deficiency diseases

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Cited by 13 publications
(7 citation statements)
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“…After diagnosis and initiation of treatment, chronic pulmonary disease can occur, particularly insidiously progressive bronchiectasis in hypogammaglobulinaemia which is often diagnosed very late, with consequent end stage lung disease and death in early adult life. Recognition is thus very important as aggressive treatment with antibiotics, physiotherapy and high dose immunoglobulin treatment may prevent progressive lung disease [7] CT, especially high resolution computed tomography (HRCT) has been shown to be more sensitive for detecting diuse lung disease than chest radiography and is the best investigation for detecting and characterising bronchiectasis [2,3,5]. It has been shown to in¯uence the treatment of bronchiectasis in adult patients with Bcell immunode®ciency [4].…”
Section: Introductionmentioning
confidence: 98%
“…After diagnosis and initiation of treatment, chronic pulmonary disease can occur, particularly insidiously progressive bronchiectasis in hypogammaglobulinaemia which is often diagnosed very late, with consequent end stage lung disease and death in early adult life. Recognition is thus very important as aggressive treatment with antibiotics, physiotherapy and high dose immunoglobulin treatment may prevent progressive lung disease [7] CT, especially high resolution computed tomography (HRCT) has been shown to be more sensitive for detecting diuse lung disease than chest radiography and is the best investigation for detecting and characterising bronchiectasis [2,3,5]. It has been shown to in¯uence the treatment of bronchiectasis in adult patients with Bcell immunode®ciency [4].…”
Section: Introductionmentioning
confidence: 98%
“…These patients often present initially with pulmonary manifestations that carry high morbidity and mortality. 1 Early diagnosis of an immunologic disorder is necessary for the provision of optimal medical care. Appropriate preventive management can minimize the number of serious consequences, including those resulting from live virus vaccines, the development of chronic lung disease and overwhelming viral, bacterial, or opportunistic infections.…”
Section: Introductionmentioning
confidence: 99%
“…Recurrent and continuous respiratory tract infections are common manifestations of hypogammaglobulinemia, and IgA and IgG subclass deficiency (1)(2)(3)(4). In addition, an impaired immune response to polysaccharides has been considered to be the cause of recurrent sinopulmonary infections in children and adults (11,14,15).…”
Section: Discussionmentioning
confidence: 99%
“…However, immunodeficiencies were equally distributed between patient groups. We conclude that only a subgroup of children with chronic chest disease have an underlying immunodefiency , but most patients (83%) do synthesize normal or even high antibodies in the presence of a bacterial load Increased frequency of infections, primarily in the respiratory tract, seems to be a major problem in a variety of immunodeficiencies, such as hypogammaglobulinernia, selective IgA deficiency and IgG subclass deficiency (1)(2)(3)(4)(5).…”
mentioning
confidence: 96%