Pulmonary manifestations of leptospirosis

Paganin, F.; Bourdin, Arnaud; Borgherini, Gianandréa; Dalban, Cécile; Poubeau, P.; Tixier, François; Gouix, A.; Noël, Jean-Luc; Cotte, L.; Arvin-Berod, C.

doi:10.1016/j.rmr.2011.09.024

Cited by 12 publications

(14 citation statements)

References 32 publications

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“…Leptospirosis on Seychelles is a severe disease leading to fatal outcomes mainly due to unusual and severe acute clinical manifestations such as pulmonary hemorrhage. 28 , 29 However, the distribution of leptospirosis cases by age-group and by gender in Seychelles is very similar to that in Reunion Island. Another similarity is the high CFR in both islands (more than 11% in Seychelles, 3–5% in Reunion Island).…”

Section: Discussionmentioning

confidence: 85%

An Observational Study of Human Leptospirosis in Seychelles

Biscornet

Comarmond

Bibi

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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. A 1-year population-based prospective study was launched in Seychelles, a country with one of the highest human incidence of leptospirosis worldwide, to describe the characteristic features of the epidemiology of the disease and highlight the most prominent risk factors. Diagnosis was based on the IgM enzyme-linked immunosorbent assay, microscopic agglutination test, and real-time PCR. A standardized questionnaire was administered to 219 patients aged ≥ 13 years consulting for acute febrile illness. The high incidence of leptospirosis in Seychelles was confirmed. The disease was particularly severe, as the case fatality rate was 11.8%. Leptospirosis was positively associated in univariate analysis with socio-professional and clinical variables including gardening/farming, oliguria, jaundice, conjunctivitis, history of hepatitis C virus infection, anemia, thrombocytopenia, and/or biological renal failure. Epidemiological analyses of the questionnaires highlighted a link of the disease with living in houses (versus apartment), the presence of animals around and in houses, gardening, and misuse of personal protective equipment. Multivariate analyses indicated that being a farmer/landscaper and having cattle and cats around the home are the most significant drivers of leptospirosis. Biological features most associated with leptospirosis were thrombocytopenia, leukocytosis, high values for renal function tests, and elevated total bilirubin. We report changes in behavior and exposure compared with data collected on leptospirosis 25 years ago, with indication that healthcare development has lowered case fatality. Continuous health education campaigns are recommended as well as further studies to clarify the epidemiology of human leptospirosis, especially the role of domestic animals.

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Section: Discussionmentioning

confidence: 85%

An Observational Study of Human Leptospirosis in Seychelles

Biscornet

Comarmond

Bibi

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…Tantitanawat et al [16] in his study of 362 patients 67(18.50%) died with acute kidney injury and pulmonary complication. Paganin et al [17] stated that the pulmonary manifestations in leptospirosis are related to a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and outcome of leptospirosis at tertiary care centre in western Maharashtra

Patil

Agrawal

2012

J Acad Med Sci

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“…All past studies showed a significant predominance of males with severe infections and a high prevalence of pulmonary manifestations. Additionally, cases occur throughout the year but primarily during the rainy season and in the rainiest areas of the island [ 12 , 13 , 14 , 15 , 16 , 17 ]. Therefore, the majority of the identified leptospirosis cases were severe and required hospital care.…”

Section: Introductionmentioning

confidence: 99%

Human Leptospirosis on Reunion Island: Past and Current Burden

Pagès

Polycarpe²,

Dehecq³

et al. 2014

IJERPH

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Since 1953, leptospirosis has been recognized as a public health problem on Reunion Island. In 2004, was implemented a specific surveillance system that included systematic reporting and the realization of environmental investigations around hospitalized cases. Here, we present the synthesis of historical data and the assessment of 9 years of leptospirosis surveillance. From 2004 to 2012, 414 hospitalized cases were reported. Cases of leptospirosis occurred mostly during the rainy season from December to May. Approximately 41% of infections occurred at home, 12% of infections occurred during aquatic leisure and 5% of cases were linked to professional activities. Furthermore, for 41% of cases, the place of infection could not be determined due to the accumulation of residential and non-residential exposure. Most of the cases of leptospirosis were linked to rural areas or traditional, rural occupations. We did not observe a shift to recreational leptospirosis as described in some developed countries. According to the new surveillance system, the number of reported cases has regularly increased since 2004. This situation is in part due to the improvement of the system in the first years but also to a real increase in the number of detected cases due to the introduction of molecular methods and to increased biological investigation into the Dengue-like syndrome by medical practitioners on the island since the Chikungunya crisis in 2006. This increase is probably due to surveillance and diagnosis biases but need to be carefully monitored. Nevertheless, the possibility of an outbreak is always present due to climatic events, such as after the “hyacinth” hurricane in 1980.

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Pulmonary manifestations of leptospirosis

Cited by 12 publications

References 32 publications

An Observational Study of Human Leptospirosis in Seychelles

An Observational Study of Human Leptospirosis in Seychelles

Clinical profile and outcome of leptospirosis at tertiary care centre in western Maharashtra

Human Leptospirosis on Reunion Island: Past and Current Burden

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