Pulmonary manifestations of systemic lupus erythematosus patients with and without antiphospholipid syndrome

Hamdani, Muhammad Afzal; Al-Arfaj, Abdurhman S.; Parvez, Khalid; Naseeb, Faisal; Ibrahim, Abdalla El Fateh; Cal, Joseph Hope

doi:10.12669/pjms.311.6544

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…24 Also, in this study, longer disease duration and higher frequency of venous thrombosis (DVT and pulmonary embolism) was found in group 1 than in group 2. This observation agrees with the findings of Hamadani and colleagues, 2015, 25 who reported that DVT was present in 3% of SLE patients compared to 27.6% of SLE/APS patients, pulmonary embolism was 3% in SLE patients compared to 34.5% in SLE/APS patients, and abortion was 7.5% of SLE patients compared to 27.6% of SLE/APS patients and they correlated the increased duration of the disease to higher frequency of complications.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Anti-β2 glycoprotein1 antibody in Systemic Lupus Erythrematosus Patients

Eldin

El-Sherif

Elgendy

et al. 2021

EJI

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Secondary anti-phospolipid syndrome (APS) is diagnosed in many patients with systemic lupus erythrematosus (SLE) especially with thromboembolic events and/or pregnancy loss in the presence of persistent laboratory evidence for anti-phospholipid antibody (aPL). In this work, we aimed to detect the prevalence of IgG and IgA anti-β2 glycoprotein1 (β2GP1) in SLE patients. Serum samples were collected from 50 female patients with SLE (25 had APS and 25 patients who did not have APS), in addition to 22 apparently healthy females with matched age as a control group. All samples from patients and control were tested for lupus anticoagulant (LA), IgG and IgA isotypes of antiβ2GPI, Anti-nuclear antibody (ANA), Anti-double strand antibody (Anti-dsDNA). Number of patients positive for Anti-β2GP1 antibodies were significantly increased in APS patients compared to non-APS patients (P=0.015). Anti-β2GP1 IgA isotype was significantly higher in APS patients than in non-APS patients (P=0.011) and significantly correlated with deep venous thrombosis and pregnancy morbidity (P=0.004). There was no difference in anti-β2GPI IgG isotype between APS patients and non-APS patients. We concluded that although anti-β2GPI IgA is not within Sapparo diagnostic criteria, it seems to contribute to the pathogenesis of thrombotic manifestations of SLE and may represents a useful indicator particularly when standard aPL tests are negative.

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Section: Discussionsupporting

confidence: 92%

Assessment of Anti-β2 glycoprotein1 antibody in Systemic Lupus Erythrematosus Patients

Eldin

El-Sherif

Elgendy

et al. 2021

EJI

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“…Regarding the other comorbidities, in our study it was determined that the presence of antiphospholipid syndrome predisposes to the presence of ARI. In similar studies, this association has been established, especially with the presence of pulmonary thromboembolism . One important finding of the present study is the presence of pericardial disease as a marker of ARI, since a statistically significant association was found in both the bivariate and multivariate analyses, which has not been reported in other studies until now, thus identifying a risk factor of significant value in patients with SLE.…”

Section: Discussionsupporting

confidence: 74%

Acute respiratory involvement in Colombian patients with systemic lupus erythematosus undergoing chest computed tomography

et al. 2019

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Introduction Systemic lupus erythematosus (SLE) is an inflammatory disease which affects multiple organs. The respiratory system is compromised in 1.6% to 36% of the patients with SLE. The objective of this study was to know the prevalence of these alterations, their associated variables, and outcomes in patients with SLE between 2012 and 2017. Methods A cross‐sectional study of 200 patients with SLE underwent chest computed tomography (CT). The primary outcome was acute respiratory involvement (ARI). A descriptive, bivariate and multivariate analysis were performed using Stata 12.0 software. Results ARI was present in 40% of the SLE patients undergoing chest CT. The most frequent ARI was pleural effusion in 33%, followed by pneumonia (16.5%), lupus pneumonitis (9%), pulmonary embolism (3%) and pulmonary hemorrhage (2.5%). In bivariate and multivariate analysis a statistically significant association between ARI and nephropathy, hematological impairment, active disease, dead, readmission and prolonged hospital stay was found. Conclusion This is the first Colombian study that evaluates ARI in patients with SLE. ARI is an important and frequent condition in patients with SLE, pleural effusion being the most prevalent cause of ARI. There are some variables (nephropathy, hematological impairment and activity disease) that are associated with ARI and could be the basis of intervention.

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“…The prevalence of PH in SLE was 2.8–23.3% 9. A comparative study was conducted in which various pulmonary manifestations in SLE patients have been studied and pulmonary hypertension was found to be one of the important complication in such patients 12. In another meta-analysis of various studies, it was found that PAH was found in 8% of SLE patients 13.…”

Section: Discussionmentioning

confidence: 99%

Frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus

et al. 2019

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Objective: To determine the frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus in a Pakistani population, presenting at a tertiary care hospital Methods: This cross-sectional study was conducted at the Department of Rheumatology, Shiekh Zayed Hospital, Lahore from March to June 2018. A total of 97 patients, who fulfilled the Systemic Lupus Erythematosus (SLE) criteria of American College of Rheumatology (ACR) 1992 were enrolled. Pulmonary Arterial Hypertension (PAH) was measured by calculating pulmonary arterial systolic pressure through echocardiography by a single consultant cardiologist. Disease characteristics and demography was collected in a self-administered proforma. PAH was defined as mean pulmonary arterial pressure of 25mmHg or above by calculating with a formula. SPSS version 20 was used for analysis of data. Results: Out of 97 patients, 89.7% (n=87) were females and 10.3% (n=10) were males, with mean age of 31.29±8.824 years. The mean disease duration was 24.21±30.46 months. PAH was found in 23.3% (n=23) patients, including 19 females and 4 males. On further analysis of data, Raynaud phenomenon, rheumatoid factor and nephritis were assessed as predictors of PAH and all of these showed statistical significance for presence of PAH as per Chi-square test (p<0.05). Conclusion: In this study, 23.3% SLE patients showed evidence of PAH and positive statistical significance was found between predictors like Raynaud phenomenon, rheumatoid factor, nephritis and presence of PAH. So it is imperative to detect PAH early and start prompt treatment to achieve better quality of life. How to cite this:Asif S, Rasheed A, Mahmud TH, Asghar A. Frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus. Pak J Med Sci. 2019;35(1):86-89. doi: https://doi.org/10.12669/pjms.35.1.405 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pulmonary manifestations of systemic lupus erythematosus patients with and without antiphospholipid syndrome

Cited by 7 publications

References 20 publications

Assessment of Anti-β2 glycoprotein1 antibody in Systemic Lupus Erythrematosus Patients

Assessment of Anti-β2 glycoprotein1 antibody in Systemic Lupus Erythrematosus Patients

Acute respiratory involvement in Colombian patients with systemic lupus erythematosus undergoing chest computed tomography

Frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus

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