Pulmonary Mechanics, Chest X‐ray and Lung Disease After Mechanical Ventilation in Low Birth Weight Infants

Lindroth, M.; Jonson, B.; Svenningsen, Nils W.; Mortensson, W.

doi:10.1111/j.1651-2227.1980.tb07146.x

Cited by 26 publications

(10 citation statements)

References 33 publications

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“…This result may seem surprising in relation to studies from the 1970s and 1980s. 19,22,23 However, preterm controls were used in this study, which is important as healthy preterms have lower compliance of the respiratory system than infants born at term, 13 and BPD has changed over the last decades. 14 The interpretation of specific conductance is more problematic.…”

Section: Discussionmentioning

confidence: 99%

Lung function at term reflects severity of bronchopulmonary dysplasia

Hjalmarson

Sandberg

2005

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 99%

Lung function at term reflects severity of bronchopulmonary dysplasia

Hjalmarson

Sandberg

2005

The Journal of Pediatrics

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“…Studies published so far have described abnormal pulmonary mechanics in infants who developed NCLD following ventilatory treatment for HMD [13][14][15][16][17][18][19][20]. Abnormal respiratory function is frequently seen as a consequence of lung damage associated with the level of treatment.…”

mentioning

confidence: 99%

Pulmonary function in infants with neonatal chronic lung disease with or without hyaline membrane disease at birth

Merth¹,

Winter²,

Zonderland³

et al. 1997

Eur Respir J

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The clinical and radiological picture of bronchopulmonary dysplasia (BPD) following prolonged mechanical ventilation and administration of high concentrations of oxygen for hyaline membrane disease (HMD), described in 1967, has become relatively rare [1]. With the advent of: antenatal corticosteroids; more gentle application of mechanical ventilation; judicious administration of fluids, nutrients and oxygen; early closure of a patent ductus arteriosus; and surfactant administration, a milder form is now more prevalent [2]. The term neonatal chronic lung disease (NCLD) is currently preferred [3]. Mostly because of the increased number of surviving infants with shorter gestation [4,5], the estimated incidence of NCLD of about 30% of all ventilated newborns has not changed since the original description of BPD [6]. NCLD is now the most prevalent chronic respiratory disorder of infancy.Expectations of a decrease in the incidence of NCLD as a result of new treatments like surfactant administration to the high-risk group [7] and more sophisticated artificial ventilation [8], have not as yet been met, although new techniques are being developed to meet the challenge [9]. Moreover, a population of very small preterm babies has recently been recognized who initially have no or only mild pulmonary disease requiring no respiratory support, but subsequently develop NCLD [3,5,10], suggesting that respiratory support is not a prerequisite for developing NCLD [6,11,12].Studies published so far have described abnormal pulmonary mechanics in infants who developed NCLD following ventilatory treatment for HMD [13][14][15][16][17][18][19][20]. Abnormal respiratory function is frequently seen as a consequence of lung damage associated with the level of treatment. On the other hand, therapeutic intervention is likely to be necessary if immaturity or prematurity are associated with compromised respiratory function at birth [21]. Only one study included both ventilated and nonventilated preterm infants [17]; in that study asymptomatic infants had normal lung function by the age of 1 yr. At school age in children born prematurely, airway diameter, as inferred from forced expiratory flows, was related only to birth weight and not to the level of respiratory therapy at birth [22,23].In the present study we analysed the association between a history of HMD, difference in ventilatory support We conclude that birth weight is the major determinant of the development of neonatal chronic lung disease. At 6 and 12 months corrected age, the abnormal pulmonary function is not associated with prior hyaline membrane disease.

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“…, t · \ days. The latter were mainly very immature preterms and some infants with severe bronSudden infant death syndrome (SIDS) occurred chopulmonary dysplasia [16]. The duration of in 4 infants, i. e. one outborn infant treated in treatment is not only related to severity of the the neonatal unit and 3 inborn infants not neonatal disease but also to other factors, e. g. treated in the neonatal unit.…”

Section: Outcomementioning

confidence: 99%