Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations

Mathieu, Patrick; Dupuis, Jocelyn; Carrier, Michel; Černáček, Peter; Pellerin, Michel; Perrault, Louis P.; Cartier, Raymond; Taillefer, Jean; Pelletier, L. C.

doi:10.1067/mtc.2001.113020

Cited by 14 publications

(7 citation statements)

References 22 publications

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“…Pulmonary ET-1 was also increased with CPB use, but similar effect was observed in off-pump group [11]. Increased levels of ET-1 were observed in both myocardial cells and myocardial circulation and attributed to CPB use [10,12].…”

Section: Introductionsupporting

confidence: 59%

“…Furthermore, they used immunohistochemical methods to test pulmonary ET-1 elimination, which was not decreased after CPB use. They concluded that increased systemic ET-1 levels were attributable to increased pulmonary production due to pulmonary endothelial dysfunction caused by CPB use [11]. In both groups of our patients, the observed nonsignificant initial increase in pulmonary ET-1 levels after anesthesia induction and sternotomy might be attributed to the use of inhalation anesthetics.…”

Section: Pulmonary Circulationmentioning

confidence: 51%

See 1 more Smart Citation

Off-pump myocardial revascularization attenuates endothelin-1 expression in systemic, pulmonary, and coronary circulation

Unić

Barić

Brkić

et al. 2014

Wien Klin Wochenschr

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In OPCAB group, ET-1 levels did not significantly vary between time points. In CABG group, ET-1 levels were significantly elevated vs. baseline in arterial: ART-T2 vs. ART-T0 (1.83 ± 1.81 vs. 0.76 ± 1.07 fmol/mL, p = 0.05), pulmonary: SG-T2 vs. SG-T0 (2.70 ± 2.75 vs. 0.39 ± 0.28 fmol/mL, p < 0.001) and SG-T3 vs. SG-T0 (1.56 ± 0.28 vs. 0.39 ± 0.28 fmol/mL, p < 0.001), and coronary circulation CS-T2 vs. CS-T1 (1.12 ± 0.49 vs. 0.27 ± 0.09 fmol/mL, p = 0.01). ET-1 levels were significantly higher in CABG group in all vascular compartments: ART-T2 (1.83 ± 1.81 vs. 0.17 ± 0.16 fmol/mL, p = 0.02), ART-T4 (0.99 ± 0.56 vs. 0.24 ± 0.12 fmol/mL, p = 0.01), SG-T1 (0.59 ± 0.15 vs. 0.25 ± 0.13 fmol/mL, p = 0.01), SG-T2 (2.70 ± 2.75 vs. 0.30 ± 0.24 fmol/mL, p = 0.004), SG-T3 (1.56 ± 0.28 vs. 0.35 ± 0.31 fmol/mL, p < 0.001), SG-T4 (1.34 ± 0.11 vs. 0.34 ± 0.16 fmol/mL, p < 0.001), and CS-T2 (1.12 ± 0.49 vs. 0.12 ± 0.12 fmol/mL, p = 0.004). Coronary sinus ET-1 level after CPB (CS-T2) in CABG group correlated positively with troponin-I level 24 h postoperatively (r(2) = 0.802, p = 0.02) CONCLUSION: Off-pump myocardial revascularization attenuates ET-1 expression in all investigated vascular compartments. Elevated coronary ET-1 levels after CPB in CABG group correlate with troponin-I levels 24 h postoperatively.

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Section: Introductionsupporting

confidence: 59%

Section: Pulmonary Circulationmentioning

confidence: 51%

Off-pump myocardial revascularization attenuates endothelin-1 expression in systemic, pulmonary, and coronary circulation

Unić

Barić

Brkić

et al. 2014

Wien Klin Wochenschr

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“…Bu nedenle KPB kullanılmadan 'off-pump' yapılarak oksidatif stres, enflamatuar yanıt gibi değişikliklerin azaltabileceği çeşitli yayınlarda da ortaya çıkarılmıştır (26)(27)(28)(29) . Çimen ve ark.…”

Section: Discussionunclassified

Preoperative, İntraoperative and Postoperative Predictors of Postoperative Respiratory System Complications in Patients Undergoing Open Heart Surgery

Sargın¹,

Aşkar²,

Kocabas³

2014

GKDA Derg

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“…CPB is associated with significant pulmonary cytokine production (IL-8), neutrophil sequestration, and alveolar macrophage activation in clinical studies. [72][73][74] Pulmonary inflammation is associated with significant increases in static and dynamic elastance of the respiratory system and lung and work of breathing. 75 In a randomized trial, however, there was no difference between these parameters in on-or off-multivessel CABG.…”

Section: Pulmonary Injurymentioning

confidence: 99%

Side Effects of Cardiopulmonary Bypass:. What Is the Reality?

Murphy

Angelini

2004

Journal of Cardiac Surgery

145

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Despite many years of clinical and experimental research, the contribution of cardiopulmonary bypass (CPB) and cardioplegic arrest to morbidity and mortality following cardiac surgery remains unclear. This is due, in part, to lack of suitable control group against which bypass and cardioplegic arrest can be compared. The recent success of beating heart coronary artery bypass grafting has, however, for the first time, provided an opportunity to compare the same operation, in similar patient groups, with, or without CPB and cardioplegic arrest. CPB is associated with an acute phase reaction of protease cascades, leucocyte, and platelet activation that result in tissue injury. This is largely manifest as subclinical organ dysfunction that produces a clinical effect in those patients that generate an excessive inflammatory response or in those with limited functional reserve. The contribution of myocardial ischemia/reperfusion, secondary to aortic cross-clamping, and cardioplegic arrest, to the systemic inflammatory response and wider organ dysfunction is unknown, and requires further evaluation in clinical trials.

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Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations

Cited by 14 publications

References 22 publications

Off-pump myocardial revascularization attenuates endothelin-1 expression in systemic, pulmonary, and coronary circulation

Off-pump myocardial revascularization attenuates endothelin-1 expression in systemic, pulmonary, and coronary circulation

Preoperative, İntraoperative and Postoperative Predictors of Postoperative Respiratory System Complications in Patients Undergoing Open Heart Surgery

Side Effects of Cardiopulmonary Bypass:. What Is the Reality?

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