Pulmonary Metastasectomy for Head and Neck Cancers

Liu, David; Labow, Daniel M.; Dang, Nick; Martini, Nael; Bains, Manjit S.; Burt, Michael; Downey, Robert J.; Rusch, Valerie W.; Shah, Jatin P.; Ginsberg, Robert J.

doi:10.1007/s10434-999-0572-8

Cited by 113 publications

(91 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7) In some reports, the 5-year survival rate in patients who underwent resection of pulmonary metastasis has been around 30% (19.4%-34.0%), suggesting the usefulness of surgical resection. [8][9][10][11] In our study, the rate was 35.7%, which was similar to those reported previously. Several reports have suggested that the factors related to a poor prognosis would include DFI, squamous cancer, male, cancer of the oral cavity, mediastinal lymph node metastasis, and the number of pulmonary metastases.…”

Section: Discussionsupporting

confidence: 92%

“…Liu reported that there was no significant difference in the survival rates between the patients who underwent a wedge resection and those that underwent lobectomy in cases demonstrating the presence of solitary pulmonary nodules of squamous cell carcinoma which could not be ruled out as being primary lung cancer. 8) On the other hand, a sublobar resection has been reported to be associated with poor outcomes and higher recurrence rates in solid types of early lung cancer. 13) Since the incidence rate of epidermal growth factor receptor (EGFR) mutation in squamous cell carcinoma is 90% in head and neck cancer, while in lung cancer it is only 0%-13%, there is a possibility that the presence of such a mutation can help to distinguish between such cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases

Nakajima

Iijima

Kinoshita

et al. 2017

ATCS

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases

Nakajima

Iijima

Kinoshita

et al. 2017

ATCS

View full text Add to dashboard Cite

“…The choice of adjuvant therapy is also affected-platinum-based chemotherapy is now frequently used for primary lung cancer, whereas its role after metastasectomy has not been studied. Finally, the 5-year survival of earlystage lung cancer after lobectomy approaches 80%, but is much lower in patients with metastatic disease (25).…”

Section: Discussionmentioning

confidence: 99%

A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma

Vachani

Nebozhyn

Singhal

et al. 2007

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: The risk of developing metastatic squamous cell carcinoma for patients with head and neck squamous cell carcinoma (HNSCC) is very high. Because these patients are often heavy tobacco users, they are also at risk for developing a second primary cancer, with squamous cell carcinoma of the lung (LSCC) being the most common.The distinction between a lung metastasis and a primary LSCC is currently based on certain clinical and histologic criteria, although the accuracy of this approach remains in question. Experimental Design: Gene expression patterns derived from 28 patients with HNSCC or LSCC from a single center were analyzed using penalized discriminant analysis. Validation was done on previously published data for 134 total subjects from four independent Affymetrix data sets. Results: We identified a panel of 10 genes (CXCL13, COL6A2, SFTPB, KRT14, TSPYL5, TMP3, KLK10, MMP1, GAS1, and MYH2) that accurately distinguished these two tumor types. This 10-gene classifier was validated on 122 subjects derived from four independent data sets and an average accuracy of 96% was shown. Gene expression values were validated by quantitative reverse transcription-PCR derived on 12 independent samples (seven HNSCC and five LSCC). The 10-gene classifier was also used to determine the site of origin of12 lung lesions from patients with prior HNSCC. Conclusions:The results suggest that penalized discriminant analysis using these 10 genes will be highly accurate in determining the origin of squamous cell carcinomas in the lungs of patients with previous head and neck malignancies.Patients with head and neck squamous cell carcinoma (HNSCC) are at high risk for the development of metastatic carcinoma in the lung. Studies suggest that 5% to 15% of patients with HNSCC develop lung metastases (1). However, because patients with HNSCC are often heavy tobacco users, they are also at risk for second primary cancers, with squamous cell carcinoma of the lung (LSCC) being the most common (2).In some cases, the distinction between a lung metastasis and a second primary lung carcinoma can be easily distinguished on clinical grounds. The presence of multiple pulmonary nodules is usually considered evidence of metastatic disease. However, in subjects who present with a solitary lung nodule, the distinction between metastasis and primary carcinoma can be more problematic. Usually, patients with HNSCC who are found to have solitary pulmonary lesions undergo surgery or needle biopsy with pathologic evaluation. If the lung lesion is also of squamous cell histology, the distinction between metastasis and primary LSCC is extremely difficult. Currently, this distinction is made by comparison of histologic grade or by the presence of other premalignant changes in the respiratory epithelium; however, the accuracy of this approach is unclear.Making the correct diagnosis has practical importance for choice of therapy. Although patients with either a primary LSCC or a solitary HNSCC metastases may be eligible for surgical resection, the c...

show abstract

“…It may be impossible to answer this question with certainty [12]. When the primary lesion occurs in the lung, the standard surgical procedure is lobectomy, but in cases of metastasis, the smallest possible area should be excised, while maintaining adequate margins.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

Yamazaki

Shodo

Ueki

et al. 2014

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Hematogenous metastasis is the most common form of metastasis in head and neck cancer, and reports have described successful resection of pulmonary metastases of such cancers. We report treatment outcomes after surgical resection of pulmonary metastases of head and neck cancer and identify prognostic factors. This clinicopathologic study investigated the clinical records of 16 patients with pulmonary metastases of head and neck cancer (excepting cases of thyroid cancer) who had undergone metastasectomy at our center during the period 2001-2012. The mean age of the 16 patients (11 men and 5 women) was 62.1 years. The mean interval between completion of successful treatment of the primary tumor and detection of pulmonary metastasis was 21 months (range, 6-56 months). All patients underwent pulmonary resection. The overall 1-year survival rate was 79.4 %, and the 2-to 5-year survival rate was 63.2 %. These rates compare favorably to those in previous reports on resection of pulmonary metastases. When prognostic factors for survival rates were compared, the factors associated with a negative prognosis were a disease-free interval of \12 months and partial resection of pulmonary metastases. Multivariate analysis did not reveal any prognostic factors associated with negative outcomes. Surgical resection of pulmonary metastases of head and neck cancer might improve outcomes.

show abstract

Pulmonary Metastasectomy for Head and Neck Cancers

Abstract: Approximately 30% of patients with pulmonary metastases from squamous cell cancers of the head and neck who underwent complete resection of all their metastases can expect to achieve long-term survival. The role of pulmonary resection for patients with glandular tumors is unclear.

Cited by 113 publications

References 18 publications

Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases

Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases

A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma

Therapeutic Outcome After Resection of Pulmonary Metastasis from Head and Neck Carcinomas

Contact Info

Product

Resources

About