Pulmonary metastasectomy in colorectal cancer: a systematic review and                quantitative synthesis

Fiorentino, Francesca; Hunt, Ian; Teoh, Kristine; Treasure, Tom; Utley, Martin

doi:10.1258/jrsm.2009.090299

Cited by 129 publications

(107 citation statements)

References 59 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to the case of liver metastasis from rectal cancers, complete resection of metastatic lung nodules also significantly improves long-term survival (13), and it has been reported that the 5-year survival rate of patients suitable for pulmonary metastasectomy is 38.3-63.7% (14). Advances in surgical techniques have resulted in the indication for pulmonary metastasectomy being extended beyond single isolated lung metastases, but the efficacy of this surgery is still unclear (15). As curative resection of pulmonary metastasis has become possible in a greater proportion of patients, preoperative investigations for metastatic staging of colon and rectal cancer are becoming increasingly important.…”

Section: Original Articlementioning

confidence: 94%

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

Han¹,

Kim²,

Park³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: The aim of this study was to evaluate the accuracy of 3-T magnetic resonance imaging (MRI) in locating rectal cancer, and to determine whether tumor location correlates with the incidence of pulmonary metastasis. Materials and Methods: A total of 146 patients with confirmed rectal adenocarcinoma underwent 3-T rectal MRI, and abdominal and chest computed tomography (CT) within 2 weeks of the endoscopic examination. We reviewed the distance between the mass and the anal verge recorded in the endoscopic reports of these patients. Two radiologists evaluated the same distance on MRI scans by using picture archiving and communications systems. Multiple factors including the tumor location, primary tumor and lymph node stage, lung and liver metastasis, pathologic differentiation, and the carcinoembryonic antigen level were evaluated. The correlation between tumor location on MRI and endoscopy was assessed, and significant factors influencing pulmonary metastasis were identified using multivariate logistic regression analysis. Results: There was a statistically significant correlation between the tumor location established using MRI and the actual location recorded during endoscopy. The incidence of pulmonary metastasis was significantly higher in patients with lower rectal cancer (11/17, 65%) compared to those with upper rectal cancer (6/17, 35%; p<0.05). Factors associated with pulmonary metastasis were tumor location and the presence of liver metastasis. Conclusion: The accurate tumor location could be indicated using 3-T rectal MRI. Pulmonary metastasis occurred more frequently in patients with lower rectal cancer than in those with upper rectal cancer.

show abstract

Section: Original Articlementioning

confidence: 94%

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

Han¹,

Kim²,

Park³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…(Figure 1) The shortest survival period after surgery was 29 days and the longest -81 months. Although CRC is referred to as a systemic disease and despite doubts about the effect of locoregional therapy in its management, many surgeons perform surgical resection of lung metastases in properly selected patients (19)(20)(21)(22)(23)(24). In general, the presence of metastases portends a poor prognosis; however, according to some studies 5-year survival rate reaches 50% (25).…”

Section: Resultsmentioning

confidence: 99%

“…Some even report 5-year survival rate of 67.2% (27). Currently, although there are studies calling into question the positive effects of surgery in patients with pulmonary metastases from CRC (22), it remains a significant component of the treatment of lung metastatic disease, and its practice is widely accepted worldwide, resulting in low mortality rates and increased five-year survival rates (28)(29)(30). …”

Section: Resultsmentioning

confidence: 99%

Survival in patients operated fn due to pulmonary metastases from colorectal carcinoma

Uchikov¹,

Ali²,

Genova³

et al. 2016

TJS

View full text Add to dashboard Cite

Introduction:Colorectal cancer (CRC) is one of the most common cancers worldwide, with greater than 1 million cases identified in the world yearly. It has got a high metastatic potential and lungs are the second most common site. Although it is referred to as a systemic disease complete surgical resection of pulmonary metastases can enhance survival in selected patients. Patients and methods:The study focuses on a sample of 13 patients surgically treated on the occasion of lung metastases from CRC; Results: We found that the mean survival in patients operated on due to pulmonary metastases from CRC was 57,1 months (95% CI; 35,400−78,907). Conclusion: Pulmonary resection of metastatic colorectal carcinoma is safe and results in longterm survival. Low morbidity and mortality rates, contrasting with lack of any other effective therapy, justify aggressive surgical management.

show abstract

“…In 1976, the study made by Herrer, et al had revealed the staging effect of CEA on colon cancer, namely preoperative elevated CEA level suggests the tumor is at an advanced stage (Herrere et al, 1979). Later, a lot of researchers also believed that preoperative CEA level was associated with the tumor range (Yamashita et al, 2009;Fiorentino et al, 2010;Xu et al, 2011). When CEA level > 20 ng/mL, the patients at phase Ducks D accounted for 37%.…”

Section: Discussionmentioning

confidence: 99%

Expression and Significance of TSGF, CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Hu¹,

Wang²,

Tao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Objective: To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Materials and Methods: Radical surgery for colon cancer was performed on 43 patients with laparoscopu under conditions of general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before and after radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining after laparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer at different levels of differentiation and clinical stagings were analyzed, and the relationships of expression rates between histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFP in cancer tissue were assessed. Results: Compared with before radical surgery, the levels of serum TSGF, CEA and AFP decreased notably in patients after operations (p<0.01). The decreased degree of TSGF and CEA was the largest in patients with poorly differentiated cancer tissue (p<0.01), while that of AFP was noted in patients with moderately differentiated cancer tissue (p<0.01). The decreased degree of TSGF and AFP was the largest in patients at phase Dukes A (p<0.01), while that of CEA in patients at phase Dukes C (p<0.01). There were no significant differences among the positive expression rates of TSGF, CEA and AFP with different histological types and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (p<0.01). Conclusions: TSGF, CEA and AFP can be used to evaluate the effect of radical operation for colon cancer, and the changed levels of different markers are associated with tumor differentiation, clinical stating and presence or absence of lymph node metastasis.

show abstract

Pulmonary metastasectomy in colorectal cancer: a systematic review and quantitative synthesis

Cited by 129 publications

References 59 publications

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

Survival in patients operated fn due to pulmonary metastases from colorectal carcinoma

Expression and Significance of TSGF, CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Contact Info

Product

Resources

About