Pulmonary MR Angiography with Ultrasmall Superparamagnetic Iron Oxide Particles as a Blood Pool Agent and a Navigator Echo for Respiratory Gating: Pilot Study

Åhlström, Håkan; Johansson, Lars; Rodenburg, J. B.; Ragnarsson, Àsgrìmur; Åkeson, Per; Børseth, A.

doi:10.1148/radiology.211.3.r99jn10865

Cited by 65 publications

(58 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a consequence of their larger size and magnetic moment, SPIOs were initially developed as T 2 -agents, producing a dark area on MRI images resulting from their negative contrast effect (19). However, a new generation of USPIOs, with sizes less than 10 nm, has also been reported to have excellent T 1 -enhancing properties (17,18,20,21).…”

Section: Superparamagnetic Agentsmentioning

confidence: 99%

Classification and basic properties of contrast agents for magnetic resonance imaging

Geraldes

Laurent

2009

Contrast Media & Molecular

491

409

View full text Add to dashboard Cite

A comprehensive classification of contrast agents currently used or under development for magnetic resonance imaging (MRI) is presented. Agents based on small chelates, macromolecular systems, iron oxides and other nanosystems, as well as responsive, chemical exchange saturation transfer (CEST) and hyperpolarization agents are covered in order to discuss the various possibilities of using MRI as a molecular imaging technique. The classification includes composition, magnetic properties, biodistribution and imaging applications. Chemical compositions of various classes of MRI contrast agents are tabulated, and their magnetic status including diamagnetic, paramagnetic and superparamagnetic are outlined. Classification according to biodistribution covers all types of MRI contrast agents including, among others, extracellular, blood pool, polymeric, particulate, responsive, oral, and organ specific (hepatobiliary, RES, lymph nodes, bone marrow and brain). Various targeting strategies of molecular, macromolecular and particulate carriers are also illustrated.

show abstract

Section: Superparamagnetic Agentsmentioning

confidence: 99%

Classification and basic properties of contrast agents for magnetic resonance imaging

Geraldes

Laurent

2009

Contrast Media & Molecular

491

409

View full text Add to dashboard Cite

show abstract

“…Numerous preclinical and several clinical studies describe their use both in MRA of individual vascular territories, such as pulmonary arteries [96], the aorta [80,97], coronary arteries [10,98,99], renal arteries [10], mesenterial and portal veins [100], hepatic veins [101], and the inferior vena cava [102], as well as in whole-body angiography of arteries and veins for assessing stenoses and thromboses [103]. Potential USPIO for clinical application are Supravist ® (SHU 555C, phase I, Bayer Healthcare Pharmaceuticals), AMI-227 (Sinerem ® , phase III), and VSOP-184 (phase I).…”

Section: T1 Applications Magnetic Resonance Angiography (Mra)mentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

124

101

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

show abstract

“…Recently, the blood pool contrast agent NC100150 has been used to achieve free-breathing pulmonary MRA with navigator echoes in normal subjects. 226 With continuing improvements in technology and validation in larger groups of diseased patients, pulmonary MRA may become competitive with the other minimally invasive imaging modalities for pulmonary embolism, including radionuclide ventilation-perfusion scanning and CT angiography.…”

Section: Yucel Et Al Magnetic Resonance Angiographymentioning

confidence: 99%

Magnetic Resonance Angiography

Yucel¹,

Anderson²,

Edelman³

et al. 1999

Circulation

126

View full text Add to dashboard Cite

Pulmonary MR Angiography with Ultrasmall Superparamagnetic Iron Oxide Particles as a Blood Pool Agent and a Navigator Echo for Respiratory Gating: Pilot Study

Cited by 65 publications

References 12 publications

Classification and basic properties of contrast agents for magnetic resonance imaging

Classification and basic properties of contrast agents for magnetic resonance imaging

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Magnetic Resonance Angiography

Contact Info

Product

Resources

About