Pulmonary Nodules in an Immunocompetent Child With Cat Scratch Disease

Bandyopadhyay, Anuja; Burrage, Lindsay C.; Gonzalez, Blanca E.

doi:10.1097/inf.0000000000000069

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Similarly, pulmonary manifestations of bartonellosis are uncommon, especially pleural effusions 12–14. Our patient presented with a trace left-sided pleural effusion that progressively advanced to mild to moderate bilateral pleural effusions that started to resolve within several days after proper antibiotic administration.…”

Section: Discussionmentioning

confidence: 69%

Pleural and pericardial effusions with fever and altered mental status: an atypical presentation of bartonellosis

Repko,

Kim,

Paulus

et al. 2024

BMJ Case Rep

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A male in his 60s presented to the emergency department (ED) with a 3-week history of fever and progressive confusion. Initial laboratory and radiographic workup was largely unremarkable except for moderate bilateral pleural effusions. The patient was admitted on broad-spectrum antibiotics and further workup for fever of unknown aetiology. The differential diagnosis was broadened to different zoonotic infections, and subsequent laboratory testing showed a markedly elevatedBartonella henselaeIgG andBartonella quintanaIgG (1:4096 and 1:512, respectively) in addition to positiveB. henselaeIgM titre (>1:20). During hospitalisation, the patient became more hypoxic and was found to have enlarging pleural effusions as well as a new pericardial effusion. The patient was treated with intravenous then oral doxycycline 100 mg two times per day and oral rifampin 300 mg two times per day for 4 weeks with subsequent improvement in clinical status as well as both effusions. This case highlights a unique presentation ofBartonellaand its rare manifestation of pleural and pericardial effusions.

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Section: Discussionmentioning

confidence: 69%

Pleural and pericardial effusions with fever and altered mental status: an atypical presentation of bartonellosis

Repko,

Kim,

Paulus

et al. 2024

BMJ Case Rep

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“…Although suspected, the primary niche of Bartonella is not known [30]. It is possible it was not obtained in these mice and could include a tissue such as the lung, where Bartonella has been found before [31][32][33]. As stated above, based on these data SW may result in an acute infection that is terminated by the immune system.…”

Section: Plos Onementioning

confidence: 94%

A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice

Bullard,

Cheslock,

Goud Gadila

et al. 2024

PLoS ONE

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Bartonellosis refers to disease caused by the Bartonella genus of bacteria. The breadth of disease manifestations associated with Bartonella is currently expanding and includes regional lymphadenopathy, rheumatic, ocular, and neurological disorders. The dearth of knowledge regarding diagnosis, treatment and pathogenesis of this disease can be partially attributed to the lack of a reliable small animal model for the disease. For this study, Bartonella henselae, the most common species associated with human disease, was injected into Swiss Webster (SW) mice. When the outcome indicated that productive infection did not occur, SCID/Beige (immune compromised) mice were inoculated. While SW mice may potentially harbor an acute infection, less than 10 days in length, the SCID/Beige model provided a sustained infection lasting up to 30-days. These data indicate that SCID/Beige mice can provide a model to study Bartonella infection, therapeutics, and vector dynamics in the future.

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BartonellaInfections

Kamath¹,

Luu²

2019

Harper's Textbook of Pediatric Dermatology

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Pulmonary Nodules in an Immunocompetent Child With Cat Scratch Disease

Abstract: We describe an immunocompetent child with cat scratch disease and pulmonary nodules as part of her initial presentation. Although pulmonary manifestations have been reported with cat scratch disease, nodules are rare in the normal host.

Cited by 5 publications

References 18 publications

Pleural and pericardial effusions with fever and altered mental status: an atypical presentation of bartonellosis

Pleural and pericardial effusions with fever and altered mental status: an atypical presentation of bartonellosis

A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice

BartonellaInfections

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