Pulmonary Nontuberculous Mycobacterial Disease

Kim, Richard D.; Greenberg, David E.; Ehrmantraut, Mary; Guide, Shireen V.; Ding, Li; Shea, Yvonne R.; Brown, Margaret R.; Chernick, Milica S.; Steagall, Wendy K.; Glasgow, Connie G.; Lin, Jing‐Ping; Jolley, Clara; Sorbara, Lynn; Raffeld, Mark; Hill, Suvimol; Avila, Nilo A.; Sachdev, Vandana; Barnhart, Lisa A.; Anderson, Victoria; Claypool, Reginald J.; Hilligoss, Dianne; Garofalo, Mary; Fitzgerald, Alan; Anaya-O’Brien, Sandra; Darnell, Dirk; DeCastro, Rosamma; Menning, Heather M.; Ricklefs, Stacy M.; Porcella, Stephen F.; Olivier, Kenneth N.; Moss, Joel; Holland, Steven M.

doi:10.1164/rccm.200805-686oc

Cited by 351 publications

(120 citation statements)

References 49 publications

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“…The finding from this study of 1 patient with Marfan syndrome and 1 patient with mitral valve prolapse is consistent with the association of predisposing genetic disorders of the connective tissue with a certain morphotype, as has been found in in the United States ( 28 ). In our cohort, 8 patients had hepatitis C (from different genotypes and with various degrees of hepatic fibrosis).…”

Section: Discussionsupporting

confidence: 91%

Clinical and Therapeutic Features of Pulmonary Nontuberculous Mycobacterial Disease, Rio de Janeiro, Brazil

Mello¹,

Mello²,

Borga³

et al. 2013

Emerg. Infect. Dis.

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To identify clinical and therapeutic features of pulmonary nontuberculous mycobacterial (PNTM) disease, we conducted a retrospective analysis of patients referred to the Brazilian reference center, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, who received a diagnosis of PNTM during 1993–2011 with at least 1 respiratory culture positive for NTM. Associated conditions included bronchiectasis (21.8%), chronic obstructive pulmonary disease (20.7%), cardiovascular disease (15.5%), AIDS (9.8%), diabetes (9.8%), and hepatitis C (4.6%).Two patients had Hansen disease; 1 had Marfan syndrome. Four mycobacterial species comprised 85.6% of NTM infections: Mycobacterium kansasii, 59 cases (33.9%); M. avium complex, 53 (30.4%); M. abscessus, 23 (13.2%); and M. fortuitum, 14 (8.0%). A total of 42 (24.1%) cases were associated with rapidly growing mycobacteria. In countries with a high prevalence of tuberculosis, PNTM is likely misdiagnosed as tuberculosis, thus showing the need for improved capacity to diagnose mycobacterial disease as well as greater awareness of PNTM disease prevalence.

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Section: Discussionsupporting

confidence: 91%

Clinical and Therapeutic Features of Pulmonary Nontuberculous Mycobacterial Disease, Rio de Janeiro, Brazil

Mello¹,

Mello²,

Borga³

et al. 2013

Emerg. Infect. Dis.

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“…The phenotypic characteristics of patients with NTM lung disease in this study were similar to those described in previous reports [3,4,13,14]. Patients with NTM lung disease were leaner than non-NTM BE patients in our study.…”

Section: Discussionsupporting

confidence: 89%

“…Frequent isolation of M. abscessus is one of the characteristics of Korean patients that differ from patients from other countries [4]. Mixed infection by two or more NTM species was observed in 23.8% (20/84) of our patients; this observation confirmed our previous retrospective study showing high rates of mixed NTM infections [17].…”

Section: Discussionsupporting

confidence: 87%

Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

Lee

Choi

et al. 2013

BMC Infect Dis

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BackgroundThis study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.MethodsWe prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.ResultsA total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.ConclusionsSignificant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.Trial registration informationClinicalTrials.gov Registration number; NCT01616745

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“…ycobacterium abscessus is an emerging pathogen responsible for lung disease, most often in predisposed patients, such as those with cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease (1,2), and it has also been described in patients without compromised lung defense (3). M. abscessus is among the top five mycobacteria responsible for respiratory tract infections.…”

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confidence: 99%

Clonal Relationship and Differentiation among Mycobacterium abscessus Isolates as Determined Using the Semiautomated Repetitive Extragenic Palindromic Sequence PCR-Based DiversiLab System

et al. 2014

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g Mycobacterium abscessus is a rapidly growing mycobacterium that causes respiratory tract infections in predisposed patients, such as those with cystic fibrosis and nosocomial skin and soft tissue infections. In order to investigate the clonal relationships between the strains causing epidemic episodes, we evaluated the discriminatory power of the semiautomated DiversiLab (DL) repetitive extragenic palindromic sequence PCR (REP-PCR) test for M. abscessus genotyping. Since M. abscessus was shown to be composed of subspecies (M. abscessus subsp. massiliense, M. abscessus subsp. bolletii, and M. abscessus subsp. abscessus), we also evaluated the ability of this technique to differentiate subspecies. The technique was applied to two collections of clinical isolates, (i) 83 M. abscessus original isolates (43 M. abscessus subsp. abscessus, 12 M. abscessus subsp. bolletii, and 28 M. abscessus subsp. massiliense) from infected patients and (ii) 35 repeated isolates obtained over 1 year from four cystic fibrosis patients. The DL REP-PCR test was standardized for DNA extraction, DNA amplification, and electrophoresis pattern comparisons. Among the isolates from distinct patients, 53/83 (62%) isolates showed a specific pattern, and 30 were distributed in 11 clusters and 6 patterns, with 2 to 4 isolates per pattern. The clusters and patterns did not fully correlate with multilocus sequence typing (MLST) analysis results. This revealed a high genomic diversity between patients, with a discriminatory power of 98% (Simpson's diversity index). However, since some isolates shared identical patterns, this raises the question of whether it is due to transmission between patients or a common reservoir. Multiple isolates from the same patient showed identical patterns, except for one patient infected by two strains. Between the M. abscessus subspecies, the indexes were <70%, indicating that the DL REP-PCR test is not an accurate tool for identifying organisms to the subspecies level. REP-PCR appears to be a rapid genotyping method that is useful for investigating epidemics of M. abscessus infections. Mycobacterium abscessus is an emerging pathogen responsible for lung disease, most often in predisposed patients, such as those with cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease (1, 2), and it has also been described in patients without compromised lung defense (3). M. abscessus is among the top five mycobacteria responsible for respiratory tract infections. It represents half of the infections caused by nontuberculous mycobacteria (NTM) and 95% of infections due to rapidly growing mycobacteria (RGM) in patients with cystic fibrosis in France (4). M. abscessus infections may lead to a rapid decline in respiratory function, and relapses are observed in patients who have undergone organ transplants (5-7). M. abscessus is also responsible for extrapulmonary infections in immunocompetent patients with outbreaks, related to surgical and cosmetic procedures, reported in various countries (8)(9)(10)(11)(12)(13)(1...

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Pulmonary Nontuberculous Mycobacterial Disease

Abstract: Patients with PNTM infection are taller and leaner than control subjects, with high rates of scoliosis, pectus excavatum, mitral valve prolapse, and cystic fibrosis transmembrane conductance regulator mutations, but without recognized immune defects.

Cited by 351 publications

References 49 publications

Clinical and Therapeutic Features of Pulmonary Nontuberculous Mycobacterial Disease, Rio de Janeiro, Brazil

Clinical and Therapeutic Features of Pulmonary Nontuberculous Mycobacterial Disease, Rio de Janeiro, Brazil

Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea

Clonal Relationship and Differentiation among Mycobacterium abscessus Isolates as Determined Using the Semiautomated Repetitive Extragenic Palindromic Sequence PCR-Based DiversiLab System

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