Pulmonary outcome of esophageal atresia patients and its potential causes in early childhood

Dittrich, René; Stock, Philippe; Rothe, K; Degenhardt, P.

doi:10.1016/j.jpedsurg.2016.12.025

Cited by 20 publications

(35 citation statements)

References 16 publications

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“…In a study of long term follow up of 27 EA patients, 63% showed abnormal lung function at rest or after exercise, 41% had restrictive ventilator defects, 48% had obstructive or combined defects. [122] Restrictive ventilator defects correlated with the interpouch distance, GERD, and recurrent pneumonia during infancy. This study highlights the importance of identifying risk factors such as GERD early on, to prevent long term affects on respiratory function.…”

Section: Extraintestinal Manifestationsmentioning

confidence: 99%

How to Care for Patients with EA-TEF: The Known and the Unknown

Mousa

Krishnan

Hassan

et al. 2017

Curr Gastroenterol Rep

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EA patients are at high risk for gastroesophageal reflux and esophageal strictures, and the sequela that result. Extraintestinal manifestations of gastroesophageal reflux disease (GERD) can appear similar to other pathologic diagnoses commonly found in EA patients, such as congenital stricture, eosinophilic esophagitis, esophageal dysmotility, tracheomalacia, recurrent fistula, aspiration, etc. Therefore, it is important to have a standardized way to monitor for these issues. pH impedance allows for detection of nonacid reflux and the height of reflux, which are important in correlating symptoms with reflux episodes. A multidisciplinary approach is beneficial in evaluating and monitoring EA patients in the long term.

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Section: Extraintestinal Manifestationsmentioning

confidence: 99%

How to Care for Patients with EA-TEF: The Known and the Unknown

Mousa

Krishnan

Hassan

et al. 2017

Curr Gastroenterol Rep

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“…4 Some mechanisms that accounted for such variability in lung function patterns were rib cage deformities secondary to surgery, bronchial hyperresponsiveness, persistent inflammation, and tracheomalacia. 6 In our cohort of patients, the restrictive pattern was more common than the obstructive and mixed patterns. Disparity was observed in the outcomes of previous studies, with some describing a higher prevalence of restrictive patterns 5 and others showing a predominant obstructive pattern.…”

Section: Figure 1 Lung Function Parametersmentioning

confidence: 58%

“…Disparity was observed in the outcomes of previous studies, with some describing a higher prevalence of restrictive patterns 5 and others showing a predominant obstructive pattern. 6,10 However, in our study, given the low percentage of patients with available data, conclusions should be made cautiously because, most likely, patients in whom lung function was expected to be mostly altered were precisely those in whom tests could not be performed adequately.…”

Section: Figure 1 Lung Function Parametersmentioning

confidence: 74%

“…5 The studies done so far in the pediatric population have demonstrated alterations in lung function tests, with the restrictive pattern as the most common one, although published data on this matter is scarce. 1,6 For these reasons, the main objective of this study was to describe the epidemiological characteristics, hospital follow-up and course of patients who underwent surgery for esophageal atresia in our hospital, and its consequences on lung function.…”

Section: Introductionmentioning

confidence: 99%

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Comorbidities and course of lung function in patients with congenital esophageal atresia

et al. 2020

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Objective. To describe the epidemiological characteristics, hospital follow-up, and course of patients who underwent surgery for esophageal atresia and its consequences on lung function. Population and methods. Retrospective, longitudinal, and analytical study. The medical records of patients with esophageal atresia born between 1996 and 2017 were reviewed. Perinatal data, type of atresia, associated malformations, respiratory and gastrointestinal complications, and spirometry data were recorded over 3 years. Results. A total of 97 patients were included. The most common type of atresia was III, and the most frequent syndrome, trisomy 21; 13.4 % of patients died in the neonatal period; 23.8 % were followed up by the Department of Pulmonology, and their respiratory complications included exacerbations (46.4 %), wheezing or asthma (36 %), and pneumonia (26.8 %). Gastroesophageal reflux was a risk factor for wheezing (OR: 5.31; p = 0.002), exacerbations (OR: 4.00; p = 0.009), and pneumonia (OR: 3.24; p = 0.02). In the first spirometry (n = 20), the pattern was normal in 65 %; restrictive in 30 %; and mixed in 5 %. In the second spirometry (n = 19), the pattern was normal in 42.1 %; restrictive in 31.6 %; obstructive in 15.8 %, and mixed in 10.5 %. In the third spirometry (n = 14), the pattern was normal in 50 %; restrictive in 21.4 %; obstructive in 14.3 %, and mixed in 14.3 %. Conclusions. In our sample of patients, a large proportion had respiratory and gastrointestinal comorbidities. Lung function worsened progressively.

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“…5 Los estudios realizados hasta el momento, en población pediátrica, demuestran alteraciones de las pruebas funcionales respiratorias, y el patrón restrictivo es el más frecuentemente encontrado, aunque los datos publicados al respecto son escasos. 1,6 Por todo esto, el objetivo principal de este estudio es describir las características epidemiológicas, el seguimiento hospitalario y la evolución de los pacientes intervenidos por atresia esofágica en nuestro Hospital, así como su repercusión en la función pulmonar.…”

Section: Vacterl (Vertebral Defects Anal a T R E S I A C A R D I Aunclassified

Comorbilidades y evolución de la función pulmonar de pacientes con atresia esofágica congénita

Blanco¹,

Gutiérrez‐Vélez²,

Solís-García³

et al. 2020

Arch Argent Pediat

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RESUMEN Objetivo. Describir las características epidemiológicas, el seguimiento hospitalario y la evolución de los pacientes intervenidos por atresia esofágica y su repercusión en la función pulmonar. Población y métodos. Estudio retrospectivo, longitudinal y analítico. Se revisaron las historias clínicas de pacientes con atresia esofágica nacidos entre 1996 y 2017. Se registraron datos perinatales, tipo de atresia, malformaciones asociadas, complicaciones respiratorias y digestivas, y los datos espirométricos durante tres años. Resultados. Se incluyeron 97 pacientes. El tipo de atresia más frecuente fue el III y el síndrome más frecuente, la trisomía 21. El 13,4 % fallecieron en el período neonatal. El 23,8 % de los pacientes estuvo en seguimiento por Neumología y presentó como complicaciones respiratorias exacerbaciones (el 46,4 %), sibilancias o asma (el 36 %), neumonías (el 26,8 %). El reflujo gastroesofágico fue factor de riesgo de sibilancias (OR 5,31; p = 0,002), exacerbaciones (OR 4,00; p = 0,009) y neumonías (OR 3,24; p = 0,02). En la primera espirometría (n = 20), un 65 % presentaba patrón normal; un 30 %, restrictivo, y un 5 %, mixto. En la segunda espirometría (n = 19), un 42,1 % presentaba patrón normal; un 31,6 %, restrictivo; un 15,8 %, obstructivo, y un 10,5 %, mixto. En la tercera espirometría (n = 14), el 50 % presentaba un patrón espirométrico normal; el 21,4 %, restrictivo; el 14,3 %, obstructivo, y un 14,3 %, mixto. Conclusiones. En nuestra muestra de pacientes, una importante proporción presentó comorbilidades respiratorias y digestivas. La función pulmonar empeoró progresivamente. Palabras clave: atresia esofágica, pruebas de función respiratoria, niños, estudios de seguimiento, comorbilidad.

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Pulmonary outcome of esophageal atresia patients and its potential causes in early childhood

Cited by 20 publications

References 16 publications

How to Care for Patients with EA-TEF: The Known and the Unknown

How to Care for Patients with EA-TEF: The Known and the Unknown

Comorbidities and course of lung function in patients with congenital esophageal atresia

Comorbilidades y evolución de la función pulmonar de pacientes con atresia esofágica congénita

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