Pulmonary plasmacytoma with endobronchial extension: A rare presentation of solitary extramedullary plasmacytoma: A case report and brief review of literature

Agrawal, Sachin; Chaudhary, Priyanka; Rajput, Atulsingh; Jain, Alok Pal

doi:10.4103/0973-1482.150350

Cited by 6 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first essential approach in the differential diagnosis of EMPs is the exclusion of other plasma cell diseases, including SBP, lymphoplasmacytic lymphoma, and especially of MM 17 . As there are no groundbreaking radiologic differential diagnosis criteria, 18 the disease must be verified histologically 19–21 . The abnormal plasma cell of an EMP originates from a cell line and also produces the same Ig, mostly IgG KLC.…”

Section: Discussionmentioning

confidence: 99%

“… 17 As there are no groundbreaking radiologic differential diagnosis criteria, 18 the disease must be verified histologically. 19 , 20 , 21 The abnormal plasma cell of an EMP originates from a cell line and also produces the same Ig, mostly IgG KLC. Despite of this fact, the presence of KLC or LLC was mentioned in only 43% of literature cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up

et al. 2022

View full text Add to dashboard Cite

Background Extramedullary plasmacytoma (EMP) is a solitary tumor consisting of neoplastic plasma cells, with very little to no bone marrow involvement. EMPs are usually located in the head and neck region, but can also occur along the digestive tract, in lungs, or extremities. Methods Following our publication on EMP, which appeared in 1999 (Cancer 85:2305–14), we conducted a literature search for EMP‐related reports published between 1999 and 2021. The documented cases, as well as 14 of our own patients from the ENT Clinic Erlangen, were extensively analyzed. Results Between 1998 and 2021, 1134 patients with EMP were reported, for whom information about the tumor localization was available. Among those, 62.4% had EMP in the head and neck area and 37.6% in other body regions. Data on therapy were reported in 897 patients, including 34.3% who received radiation, 28.1% surgery, 22.6% a combination of surgery and radiation, and 15.9% another therapy. In 76.9% patients no recurrence or transformation to multiple myeloma (MM) was reported, 12.8% showed local recurrence and 10.2% developed MM. Radiotherapy alone was associated with a tendency for increased occurrence of MM. In patients with EMP of head and neck area, combination therapy (surgery and radiation) resulted in a 5‐year overall survival rate of 98.3%, surgery alone of 92.4%, and radiotherapy of 92.7%. Conclusions Collectively, our analyses indicate that surgical resection alone can achieve long‐term tumor control in patients with EMP, if the tumor can be removed within safe limits without causing serious functional impairment. However, if this is not certain, either radiation or a combination of surgery and radiation therapy is suggested as an effective means of local tumor control.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Extramedullary localization in the respiratory tract is described in approximately 80% of patients, most often localized in the upper respiratory tract and nasopharyngeal (65-80%), while lung involvement is described much less often in 3-5% of cases (16,20,29,30). Extramedullary pulmonary plasmacytoma in our patient also represent the initial manifestation of multiple myeloma, which was clinically almost asymptomatic, and mild nonspecific complaints on the left chest, which occasionally occurred, did not attract attention, and at the moment of diagnosis, pulmonary changes were 9cm in size, with pleural infiltration, intercostal muscles and destruction of V rib.…”

Section: Discussionmentioning

confidence: 99%

Acute kidney failure and extramedullary lung infiltration as initial presentation of multiple myeloma - case report

et al. 2021

View full text Add to dashboard Cite

Introduction. Kidney failure in multiple myeloma is sometimes an initial symptomatology and a very serious complication with an unfavorable effect on the course and prognosis of the disease. Multiple myeloma is a disease characterized by proliferation of plasmocytes in the bone marrow, and in rare cases it can be extramedullary in various organs and systems. Pulmonary plasmacytoma localization is a rare extramedullary localization, especially when it represents one of the initial manifestations of multiple myeloma. Case report. We present a patient with a progression of acute kidney failure where hemodialysis treatment started. On the chest radiography, a homogeneous shadow was observed along the left chest wall, and MSCT pointed to the tumor formation in the pulmonary parenchyma in the projection of the left upper pulmonary lobe with signs of pleural infiltration, intercostal muscles and V rib destruction. Laboratory examination indicated presence of Bence -Jones proteinuria in the urine sample in addition to anemia syndrome and azotemia with hyperuricemia. After bronchoscopy and needle biopsy, diffuse infiltration of mature plasma cells was demonstrated in the cytological and pathohistological findings of the lungs. The pathohistological finding of bone marrow biopsy indicated multiple myeloma -Lambda type with infiltration of plasma cells -about 70%. Hematologist determined a diagnosis of multiple myeloma BJ lambda III BCS, with extramedullary lung infiltration and acute kidney failure. Further treatment was continued according to the hematological protocol while performing intermittent hemodialysis.Conclusion. Sometimes, extremely rarely, and in completely asymptomatic patients with massive pulmonary infiltration observed initially, differential diagnosis may also represent an extramedullary presentation of a multiple myeloma, which should be considered.

show abstract

“…Case reports cite a variety of intrapulmonary locations from the mediastinal airways, through hilar (Luh et al 2007) to peripheral parenchyma (Agrawal et al 2015). Pleural involvement is a recorded feature with direct spread from adjacent lung, and apparently singular pleural infiltration is also noted.…”

Section: • Sitementioning

confidence: 99%

Plasma Cell Tumors

Johnston¹

2017

Encyclopedia of Pathology

View full text Add to dashboard Cite

Pulmonary plasmacytoma is a neoplasm composed of monoclonal plasma cells sited in the lung or related tissues. It is often solitary on imaging by plain chest x-ray, CT, or MRI but can be multiple and may occur within the diagnostic umbrella of multiple myeloma. The condition is often a serendipitous finding although patients may present with non-specific (e.g., malaise, weight loss) or respiratory symptoms (e.g., cough, dyspnea, bloodstained sputum) and signs (e.g., crackles of variable coarseness on auscultation).

show abstract

Pulmonary plasmacytoma with endobronchial extension: A rare presentation of solitary extramedullary plasmacytoma: A case report and brief review of literature

Cited by 6 publications

References 1 publication

Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up

Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts—A follow‐up

Acute kidney failure and extramedullary lung infiltration as initial presentation of multiple myeloma - case report

Plasma Cell Tumors

Contact Info

Product

Resources

About