Pulmonary pressor action of I-norepinephrine and angiotensin

Fowler, Noble O.; Holmes, John C.

doi:10.1016/0002-8703(65)90132-8

Cited by 10 publications

(3 citation statements)

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“…The increase in pulmonary arterial pressure observed in some dogs was not striking, and in 3 dogs the pressure actually decreased. This was consistent with studies on animals in which pulmonary blood flow and l'eft atrial pressure were controlled (8,9,15). I n these latter studies the lrise in pulmonary arterial pressure was considered to be due to an increase in left atrial pressure (8) or to systemic effects resulting in an increase in PBV (15).…”

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confidence: 82%

“…It was found that in proper doses angiotensin I1 can constrict systemic precapillary (resistance) vessels without affecting equally postcapillary (capacitance) vessels. Although some studies of the effects of angiotensin I1 on the pulmonary circulation have been reported (8,9), the effect on small pulmonary veins of intact dogs has not been previously studied. I n these experiments simultaneous pressures and volume flow measurements in many sites of the pulmonary and systemic circulations were olbtained in intact dogs during an intravenous infusion of angiotensin I1 to learn whethler or not the hemodynamic effects of angiotensin I1 on the pulmonary and systemic venous circulations differ.…”

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Influence of Angiotensin II on the Systemic and Pulmonary Circulations of Intact Anesthetized Dogs

Giles

Shen

Dhurandhar

et al. 1969

Experimental Biology and Medicine

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Initial hemodynamic studies of angiotensin I1 were primarily concerned with the influence on arterial blood pressure (1-5). Our interest in the venous system and recognition of its importance in regulation of the circulation prompted these studies to define more clearly the effects of angiotensin I1 on the veins (6, 7). It was found that in proper doses angiotensin I1 can constrict systemic precapillary (resistance) vessels without affecting equally postcapillary (capacitance) vessels. Although some studies of the effects of angiotensin I1 on the pulmonary circulation have been reported (8, 9), the effect on small pulmonary veins of intact dogs has not been previously studied. I n these experiments simultaneous pressures and volume flow measurements in many sites of the pulmonary and systemic circulations were olbtained in intact dogs during an intravenous infusion of angiotensin I1 to learn whethler or not the hemodynamic effects of angiotensin I1 on the pulmonary and systemic venous circulations differ.Material and Methods. Fifteen mongrel dogs weighing 15.0-18.2 kg were lightly anesthetized with urethane (1.5 g/kg) and loosely taped supine to a fluoroscopic table. After the trachea was intubated, 100% oxygen was administered into the lendotracheal tube via a plastic catheter at a rate of 2-2.5 1itersJmin in order to assure that the animals were not hypoxic.Catheters were placed in the left atrium and a small pulmonary vein of the lower lobe 1 Supported by grants HE-06769 from the National Heart Institutes of the US. Public Health Service; the Rudolph Matas Memorial Fund for the Kate Prewitt Hess Laboratory; and the Rowell A. Billups Fund for Research in Heart Disease.of the left lung by the transseptal technique ( l o ) . The pulmonary vein catheter had an internal diameter of 0.5 mm and an external diameter of 0.91 mm.Previous studies showed that this catheter did not significantly alter the pressure in the pulmonary vein ( 11 ) . Catheters were also placed in the main pulmonary artery, right femoral artery, right atrium, and a small vein of the left leg. Stathani strain gauge transducers (P23Db) were used to monitor pressures which were recorded with an Electronics for Medicine research recorder. A catheter for infusion of angiotensin I1 was placed in the right femoral vein.After control pressure tracings were recorded, cardiac output and pulmonary blood volume were determined by the indicator dilution technique using indocyanine green (Cardio-Green) ( 12). The stroke volume and pulmonary and systemic vascular resistances were calculated by methods previously described (13). The pulmonary venous resistance was calculated by the formula: Pulmonary venous resistance = PVS -PLA/CO, where PVS is pressure in small pulmonary vein, PLA is left atrial pressure and CO is cardiac output. Lead I1 of the electrocardiogram, heart rate and respiratory rate were also monitored.After a "steady state" was reached for 10-15 min, as indicated by relatively constant cardiac output and pressures, angiotensin I1 ( 5 pg/min) was i...

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Influence of Angiotensin II on the Systemic and Pulmonary Circulations of Intact Anesthetized Dogs

Giles

Shen

Dhurandhar

et al. 1969

Experimental Biology and Medicine

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“…The experimental design for equal perfusion of the systemic and pulmonary circulations with a roller pump is described in detail elsewhere (10) and is only summarized here. Three animals were anesthetized with pentobarbital sodium, 30 mg per kg, intravenously.…”

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confidence: 99%

Pulmonary arterial pressure at high pulmonary flow.

Fowler¹,

Holmes²

1965

J. Clin. Invest.

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The relationship between pulmonary arterial pressure and pulmonary blood flow has been studied by a number of investigators in anesthetized animals (1), in man after pneumonectomy or unilateral pulmonary arterial occlusion (2, 3), and in normal man during exercise (4-7). With a few exceptions (1) these studies have agreed that doubling or trebling the pulmonary arterial flow does not produce a comparable increase of pulmonary arterial pressure. Sloan, Morris, Figley, and Lee (2) and Brofman (3) found in human subjects only a very slight rise of pulmonary arterial pressure during balloon occlusion of one main pulmonary artery branch when cardiovascular dynamics were normal. However, the relationship between pulmonary arterial pressure and pulmonary arterial blood flow at higher rates of flow has been examined by only a few investigators.In 1950, Cournand, Riley, Himmelstein, and Austrian (8) published studies of pulmonary blood pressure in normal physicians at rest and during exercise and in patients who had had a pneumonectomy with a normal remaining lung. These investigators concluded that pulmonary blood flow in man can increase to approximately three times the normal before the pulmonary arterial pressure will rise above normal limits. Lategola studied pulmonary pressure and flow relationships at high flow levels achieved by occluding 50% or more of the pulmonary circulation in anesthetized dogs (9). Lategola also found that when pulmonary blood flow was increased to approximately 250 to 300% above normal, the pressure rose sharply. * Submitted for publication March 15, 1965; accepted September 16, 1965. Supported by U. S. Public Health Service grants HE-06307 and HE-5445. Unlike Cournand, he found some increment of pulmonary arterial pressure even when pulmonary blood flow was increased less than 100% above the normal.In the foregoing studies of high pulmonary blood flow, the methods used for measuring pulmonary blood flow were necessarily indirect, and left atrial pressure was not measured. Thus the effect of pulmonary blood flow upon pulmonary vascular resistance could not be accurately computed. The purpose of the present study is to examine in anesthetized dogs the effect of increase of pulmonary blood flow under circumstances that permitted direct measurement of pulmonary blood flow and left atrial pressure. The pulmonary blood flows were measured at levels from 50% to 500% of normal,' and left atrial pressures were held constant in some experiments. MethodsThe experiments were performed upon 19 mongrel dogs that were in three groups.Group 1 consisted of nine dogs. The experimental design for equal perfusion of the systemic and pulmonary circulations with a roller pump is described in detail elsewhere (10) and is only summarized here. Three animals were anesthetized with pentobarbital sodium, 30 mg per kg, intravenously. Six received morphine sulfate, 5 mg per kg, intramuscularly followed by intravenous chloralose in amounts required to maintain anesthesia. The animals received heparin, 5 mg per kg, ...

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Circulatory Effects of Angiotensin

Buñag¹

1974

Angiotensin

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Pulmonary pressor action of I-norepinephrine and angiotensin

Cited by 10 publications

References 22 publications

Influence of Angiotensin II on the Systemic and Pulmonary Circulations of Intact Anesthetized Dogs

Influence of Angiotensin II on the Systemic and Pulmonary Circulations of Intact Anesthetized Dogs

Pulmonary arterial pressure at high pulmonary flow.

Circulatory Effects of Angiotensin

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