Pulmonary rehabilitation and COPD: is nonlinear exercise better?

Sant’Anna, Thaís; Hernandes, Nídia A.; Pitta, Fábio

doi:10.1586/17476348.2013.814395

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…24 Pulmonary rehabilitation is traditionally recommended for patients with moderate to severe COPD. Although pulmonary rehabilitation, bronchodilators and anti-inflammatory agents provides the greatest improvement in dyspnea, exercise tolerance, and health-related quality of life, 25 it is very difficult to change physical activity and with poor outcome. 26 Therefore, COPD is a major heterogeneous disease and one of the world’s leading causes of death, and it is urgent for diagnostic and prognostic biomarkers for COPD.…”

Section: Discussionmentioning

confidence: 99%

Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics

Han¹,

Lü²

2022

COPD

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Background Chronic obstructive pulmonary disease (COPD) is a common chronic disease of the respiratory tract, with high prevalence, high disability, and poor prognosis. However, the molecular mechanism of COPD needs to be further revealed. Methods We obtained the gene expression profile and miRNA expression profile of COPD patients from Gene Expression Omnibus (GEO) database, and the differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmis) in COPD were identified. Subsequently, the COPD-related ceRNA network was constructed based on the interaction between lncRNA, miRNA, and mRNA using the lncACTdb database. Finally, the Cytoscape software was used to analyze the network topology and COPD-related lncRNAs. Results Firstly, the 519 DEGs and 17 DEmis were identified from COPD GEO datasets. GO enrichment showed that leukocyte chemotaxis, cell chemotaxis, and myeloid leukocyte migration were upregulated, and muscle and membrane repolarization-related biological progress were downregulated in COPD. KEGG pathway enrichment shows that the p53 pathway was upregulated in COPD. Hallmark enrichment showed that chronic neutrophil inflammation was a sign of the pathogenesis of COPD. Next, a ceRNA network including 93 DEGs, 2 DEmi, 463 lncRNAs, and 1157 DEG-lncRNA, DEmi-lncRNA, and DEmi-DEG interactions were obtained. The hub-lncRNA (the network is ranked in the top 10) as the core marker of COPD, including SNHG12, SLFNL1-AS1, KCNQ1OT1, XIST, EAF1-AS1, FOXD2-AS1, NORAD, PINK1-AS and RP11-69E11.4. And the cytoHubba analysis identified ATM, SMAD7 and HIF1A as hub genes of ceRNA network. Conclusion This study provides a landscape of ceRNA network of COPD, which help to reveal the underlying pathophysiological mechanisms of COPD and shed light on novel therapeutic strategies for COPD.

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Section: Discussionmentioning

confidence: 99%

Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics

Han¹,

Lü²

2022

COPD

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“…The latter thus affects the generalizability of findings to other settings. 34,35 A possible answer to some of the methodological challenges stated above would be to employ a more pragmatic approach in the RCT design. 37 In brief, pragmatic RCTs can be defined as a study design which determines whether interventions will work in the real-life setting.…”

Section: Discussionmentioning

confidence: 99%

The use of periodized exercise prescription in rehabilitation: a systematic scoping review of literature

2018

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Periodization models of exercise prescription are being used within a variety of population groups in the rehabilitation setting. Integration of periodization principles into a rehabilitation programme still however remains a challenge. Although there is a lack of consistency with regard to the structure and implementation of a periodized model of exercise prescription in the rehabilitation context, it seems to be an alternative way in which to prescribe exercise within the rehabilitation setting.

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“…On the other hand, even if the traditional treatments including lung volume reduction surgery for COPD have made great strides, there were still some uncontrollable complications [ 9 ]. In addition, even if some pulmonary rehabilitation programs, such as exercise training, education, and behavior change followed by patient-tailored therapies have been regarded as promising measures for improving the COPD patients, a few patients still cannot gain the benefit from the exercise training [ 10 ]. Hence, it is very wishful for further parsing the molecular mechanism and recognizing the novel biomarkers of COPD.…”

Section: Introductionmentioning

confidence: 99%

Identification of Macrophage Polarization‐Related Genes as Biomarkers of Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analyses

Zhao

Yang

et al. 2021

BioMed Research International

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Objectives. Chronic obstructive pulmonary disease (COPD) is characterized by lung inflammation and remodeling. Macrophage polarization is associated with inflammation and tissue remodeling, as well as immunity. Therefore, this study attempts to investigate the diagnostic value and regulatory mechanism of macrophage polarization-related genes for COPD by bioinformatics analysis and to provide a new theoretical basis for experimental research. Methods. The raw gene expression profile dataset (GSE124180) was collected from the Gene Expression Omnibus (GEO) database. Next, a weighted gene coexpression network analysis (WGCNA) was conducted to screen macrophage polarization-related genes. The differentially expressed genes (DEGs) between the COPD and normal samples were generated using DESeq2 v3.11 and overlapped with the macrophage polarization-related genes. Moreover, functional annotations of overlapped genes were conducted by Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resource. The immune-related genes were selected, and their correlation with the differential immune cells was analyzed by Pearson. Finally, receiver operating characteristic (ROC) curves were used to verify the diagnostic value of genes. Results. A total of 4922 coexpressed genes related to macrophage polarization were overlapped with the 203 DEGs between the COPD and normal samples, obtaining 25 genes related to COPD and macrophage polarization. GEM, S100B, and GZMA of them participated in the immune response, which were considered the candidate biomarkers. GEM and S100B were significantly correlated with marker genes of B cells which had a significant difference between the COPD and normal samples. Moreover, GEM was highly associated with the genes in the PI3K/Akt/GSK3β signaling pathway, regulation of actin cytoskeleton, and calcium signaling pathway based on a Pearson correlation analysis of the candidate genes and the genes in the B cell receptor signaling pathway. PPI network analysis also indicated that GEM might participate in the regulation of the PI3K/Akt/GSK3β signaling pathway. The ROC curve showed that GEM possessed an excellent accuracy in distinguishing COPD from normal samples. Conclusions. The data provide a transcriptome-based evidence that GEM is related to COPD and macrophage polarization likely contributes to COPD diagnosis. At the same time, it is hoped that in-depth functional mining can provide new ideas for exploring the COPD pathogenesis.

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Pulmonary rehabilitation and COPD: is nonlinear exercise better?

Cited by 6 publications

References 19 publications

Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics

Revealing lncRNA Biomarkers Related to Chronic Obstructive Pulmonary Disease Based on Bioinformatics

The use of periodized exercise prescription in rehabilitation: a systematic scoping review of literature

Identification of Macrophage Polarization‐Related Genes as Biomarkers of Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analyses

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