Pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improves pulmonary function

Tarumi, Shintaro; Yokomise, Hiroyasu; Gotoh, Masashi; Kasai, Yoshitaka; Matsuura, Natsumi; Chang, Sung Soo; Go, Tetsuhiko

doi:10.1016/j.jtcvs.2014.09.123

Cited by 43 publications

(32 citation statements)

References 25 publications

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“…At 8–10 weeks, significant increases in forced vital capacity (FVC; +6.4%, p = .0096) and in FEV1 (+ 10.4%, p < .0001) were found, whereas the DLCO decreased. Even in current or former smokers, an improvement in FEV1 was observed, whereas patients with respiratory impairment experienced a greater increase in both FVC (+13.9%, p = .0025) and FEV1 (+ 22.5%, p < .0001) . Collectively, these results should be interpreted cautiously, because some studies lack a control group and several aspects need to be further defined, mainly about the potential role of EX on postsurgery compensatory mechanisms.…”

Section: Investigated Outcomes In Lung Cancermentioning

confidence: 92%

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Avancini

Sartori

Gkountakos³

et al. 2019

The Oncologist

124

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Lung cancer remains the leading cause of cancer‐related death worldwide. Affected patients frequently experience debilitating disease‐related symptoms, including dyspnea, cough, fatigue, anxiety, depression, insomnia, and pain, despite the progresses achieved in term of treatment efficacy. Physical activity and exercise are nonpharmacological interventions that have been shown to improve fatigue, quality of life, cardiorespiratory fitness, pulmonary function, muscle mass and strength, and psychological status in patients with lung cancer. Moreover, physical fitness levels, especially cardiorespiratory endurance and muscular strength, are demonstrated to be independent predictors of survival. Nevertheless, patients with lung cancer frequently present insufficient levels of physical activity and exercise, and these may contribute to quality of life impairment, reduction in functional capacity with skeletal muscle atrophy or weakness, and worsening of symptoms, particularly dyspnea. The molecular bases underlying the potential impact of exercise on the fitness and treatment outcome of patients with lung cancer are still elusive. Counteracting specific cancer cells’ acquired capabilities (hallmarks of cancer), together with preventing treatment‐induced adverse events, represent main candidate mechanisms. To date, the potential impact of physical activity and exercise in lung cancer remains to be fully appreciated, and no specific exercise guidelines for patients with lung cancer are available. In this article, we perform an in‐depth review of the evidence supporting physical activity and exercise in lung cancer and suggest that integrating this kind of intervention within the framework of a global, multidimensional approach, taking into account also nutritional and psychological aspects, might be the most effective strategy. Implications for Practice Although growing evidence supports the safety and efficacy of exercise in lung cancer, both after surgery and during and after medical treatments, most patients are insufficiently active or sedentary. Engaging in exercise programs is particularly arduous for patients with lung cancer, mainly because of a series of physical and psychosocial disease‐related barriers (including the smoking stigma). A continuous collaboration among oncologists and cancer exercise specialists is urgently needed in order to develop tailored programs based on patients’ needs, preferences, and physical and psychological status. In this regard, benefit of exercise appears to be potentially enhanced when administered as a multidimensional, comprehensive approach to patients’ well‐being.

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Section: Investigated Outcomes In Lung Cancermentioning

confidence: 92%

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Avancini

Sartori

Gkountakos³

et al. 2019

The Oncologist

124

View full text Add to dashboard Cite

show abstract

“…amegroups.com/public/system/jtd/jtd.2018.03.147-1. pdf) (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42). summarises the key findings, in brief, studies reported a statistically significant improvement in peak oxygen consumption (VO2max) or in functional capacity measured with the 6-minute walk test from baseline to postintervention.…”

Section: Does It Work?mentioning

confidence: 99%

The key questions in rehabilitation in thoracic surgery

Mahendran¹,

Naidu²

2018

J. Thorac. Dis.

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“…PR plays a role in the management of terminal cancer. Exercise training modalities include walking with/without assistance or device, passive or active strengthening exercises, continuous passive motion, passive or active range of motion, NMES, and pain management interventions such as massage and heating pads [101]. Oxygen therapy has an important role in palliative care because it both treats hypoxemia and reduces the sensation of dyspnea.…”

Section: Lung Cancermentioning

confidence: 99%

Advances in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease and Associated Conditions

Candemir¹

2018

COPD - An Update in Pathogenesis and Clinical Management

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Pulmonary rehabilitation (PR) is an evidenced-based, proven treatment as mentioned recent guidelines in patients with chronic obstructive pulmonary disease (COPD). Exercise training is a cornerstone of PR programs, Inspiratory muscle training, neuromuscular electrical stimulation (NMES) are effective in selected patients. Water-based rehabilitation and tai chi are well tolerated recent modalities. Although there is an absence of a specific PR protocol for special conditions, PR is recommended before and also after endobronchial volume reduction (EBVR), lung volume reduction surgery (LVRS), both before and after lung transplantation periods, before, after surgery, during the intensive care unit (ICU) period, the chemotherapy period and as a component of palliative care. After COPD exacerbation, it is recommended within 3 weeks of hospital discharge. Modifying PR programs while considering comorbidities might lead to greater improvement in outcomes. After PR, the important points are to follow prescribed home exercise programs, control programs in the PR center/unit, and being more active in daily living life for the purpose of preserving improvements. Tele-PR is an alternative to conventional modalities due to similar improvements. Although PR is effective, it is an underutilized resource. The awareness of PR should be increased in patients and among health professionals.

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Pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improves pulmonary function

Abstract: A pulmonary rehabilitation program for patients with non-small cell lung cancer undergoing induction chemoradiotherapy seems to improve respiratory function. It is particularly recommended for smokers and patients with respiratory impairment.

Cited by 43 publications

References 25 publications

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

The key questions in rehabilitation in thoracic surgery

Advances in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease and Associated Conditions

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